Targeting SYNthetic lethal interactions for new cancer treatments TRAINing network

Rezultaty

Scientific publications

Task 5.6: Publish research findings (leads: all beneficiaries).

Direct interaction with the public

Task 5.3: Perform public outreach activities (all ESRs; lead: B7-UNIGE).

Presentations at scientific conferences

Task 5.5: Present research findings at international scientific conferences (leads: all beneficiaries).

Press releases

Task 5.4: Produce press releases (lead: B6-UOXF)

SYNTRAIN website

Task 5.1: Establishment of SYNTRAIN website (lead: B1-UCPH).

International scientific conference

Task 4.5: Organization of international scientific conference (leads: B3-UPAT and B5-DCS).

PhD theses

Task 4.6: Awarding of doctoral degrees (leads: all beneficiaries).

Publikacje

Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination

Autorzy: Nina M. S. Gustafsson, Katarina Färnegårdh, Nadilly Bonagas, Anna Huguet Ninou, Petra Groth, Elisee Wiita, Mattias Jönsson, Kenth Hallberg, Jemina Lehto, Rosa Pennisi, Jessica Martinsson, Carina Norström, Jessica Hollers, Johan Schultz, Martin Andersson, Natalia Markova, Petra Marttila, Baek Kim, Martin Norin, Thomas Olin, Thomas Helleday
Opublikowane w: Nature Communications, Numer 9/1, 2018, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-018-06287-x

Targeting CX3CR1 Suppresses the Fanconi Anemia DNA Repair Pathway and Synergizes with Platinum

Autorzy: Jemina Lehto, Anna Huguet Ninou, Dimitrios Chioureas, Jos Jonkers, Nina M. S. Gustafsson
Opublikowane w: Cancers, Numer 13/6, 2021, Strona(/y) 1442, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13061442

OGG1 Inhibitor TH5487 Alters OGG1 Chromatin Dynamics and Prevents Incisions

Autorzy: Bishoy M. F. Hanna, Thomas Helleday, Oliver Mortusewicz
Opublikowane w: Biomolecules, Numer 10/11, 2020, Strona(/y) 1483, ISSN 2218-273X
Wydawca: Biomolecules
DOI: 10.3390/biom10111483

Targeting OGG1 arrests cancer cell proliferation by inducing replication stress

Autorzy: Torkild Visnes, Carlos Benítez-Buelga, Armando Cázares-Körner, Kumar Sanjiv, Bishoy M F Hanna, Oliver Mortusewicz, Varshni Rajagopal, Julian J Albers, Daniel W Hagey, Tove Bekkhus, Saeed Eshtad, Juan Miguel Baquero, Geoffrey Masuyer, Olov Wallner, Sarah Müller, Therese Pham, Camilla Göktürk, Azita Rasti, Sharda Suman, Raúl Torres-Ruiz, Antonio Sarno, Elisée Wiita, Evert J Homan, Stella Kar
Opublikowane w: Nucleic Acids Research, 2020, ISSN 0305-1048
Wydawca: Oxford University Press
DOI: 10.1093/nar/gkaa1048

Cellular senescence and failure of myelin repair in multiple sclerosis

Autorzy: Paraskevi N. Koutsoudaki, Dimitrios Papadopoulos, Panagiotis-Georgios Passias, Pinelopi Koutsoudaki, Vassilis G. Gorgoulis
Opublikowane w: Mechanisms of Ageing and Development, Numer 192, 2020, Strona(/y) 111366, ISSN 0047-6374
Wydawca: Elsevier BV
DOI: 10.1016/j.mad.2020.111366

DNA Damage and Cancer Immunotherapy: A STING in the Tale

Autorzy: Timo Reisländer, Florian J. Groelly, Madalena Tarsounas
Opublikowane w: Molecular Cell, Numer 80/1, 2020, Strona(/y) 21-28, ISSN 1097-2765
Wydawca: Cell Press
DOI: 10.1016/j.molcel.2020.07.026

Mitochondrial Homeostasis and Cellular Senescence

Autorzy: Panagiotis Vasileiou, Konstantinos Evangelou, Konstantinos Vlasis, Georgios Fildisis, Mihalis Panayiotidis, Efstathios Chronopoulos, Panagiotis-Georgios Passias, Mirsini Kouloukoussa, Vassilis Gorgoulis, Sophia Havaki
Opublikowane w: Cells, Numer 8/7, 2019, Strona(/y) 686, ISSN 2073-4409
Wydawca: Cells
DOI: 10.3390/cells8070686

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

Autorzy: Torkild Visnes, Armando Cázares-Körner, Wenjing Hao, Olov Wallner, Geoffrey Masuyer, Olga Loseva, Oliver Mortusewicz, Elisée Wiita, Antonio Sarno, Aleksandr Manoilov, Juan Astorga-Wells, Ann-Sofie Jemth, Lang Pan, Kumar Sanjiv, Stella Karsten, Camilla Gokturk, Maurice Grube, Evert J. Homan, Bishoy M. F. Hanna, Cynthia B. J. Paulin, Therese Pham, Azita Rasti, Ulrika Warpman Berglund, Catharina v
Opublikowane w: Science, Numer 362/6416, 2018, Strona(/y) 834-839, ISSN 0036-8075
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/science.aar8048

Germline RBBP8 variants associated with early-onset breast cancer compromise replication fork stability

Autorzy: Reihaneh Zarrizi, Martin R. Higgs, Karolin Voßgröne, Maria Rossing, Birgitte Bertelsen, Muthiah Bose, Arne Nedergaard Kousholt, Heike Rösner, the COMPLEXO Network, Bent Ejlertsen, Grant S. Stewart, Finn Cilius Nielsen, Claus S. Sørensen
Opublikowane w: Journal of Clinical Investigation, Numer bi weekly, 2020, Strona(/y) 4069-4080, ISSN 0021-9738
Wydawca: American Society for Clinical Investigation
DOI: 10.1172/jci127521

Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses

Autorzy: Marianna Tampere, Aleksandra Pettke, Cristiano Salata, Olov Wallner, Tobias Koolmeister, Armando Cazares-Körner, Torkild Visnes, Maria Carmen Hesselman, Elena Kunold, Elisee Wiita, Christina Kalderén, Molly Lightowler, Ann-Sofie Jemth, Janne Lehtiö, Åsa Rosenquist, Ulrika Warpman-Berglund, Thomas Helleday, Ali Mirazimi, Rozbeh Jafari, Marjo-Riitta Puumalainen
Opublikowane w: Viruses, Numer 12/12, 2020, Strona(/y) 1423, ISSN 1999-4915
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12121423

Chlorambucil targets BRCA 1/2‐deficient tumours and counteracts PARP inhibitor resistance

Autorzy: Eliana MC Tacconi, Sophie Badie, Giuliana De Gregoriis, Timo Reisländer, Xianning Lai, Manuela Porru, Cecilia Folio, John Moore, Arnaud Kopp, Júlia Baguña Torres, Deborah Sneddon, Marcus Green, Simon Dedic, Jonathan W Lee, Ankita Sati Batra, Oscar M Rueda, Alejandra Bruna, Carlo Leonetti, Carlos Caldas, Bart Cornelissen, Laurent Brino, Anderson Ryan, Annamaria Biroccio, Madalena Tarsounas
Opublikowane w: EMBO Molecular Medicine, Numer 11/7, 2019, ISSN 1757-4676
Wydawca: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201809982

A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence

Autorzy: Eirini-Stavroula Komseli, Ioannis S. Pateras, Thorbjørn Krejsgaard, Konrad Stawiski, Sophia V. Rizou, Alexander Polyzos, Fani-Marlen Roumelioti, Maria Chiourea, Ioanna Mourkioti, Eleni Paparouna, Christos P. Zampetidis, Sentiljana Gumeni, Ioannis P. Trougakos, Dafni-Eleftheria Pefani, Eric O’Neill, Sarantis Gagos, Aristides G. Eliopoulos, Wojciech Fendler, Dipanjan Chowdhury, Jiri Bartek, Vassi
Opublikowane w: BMC Genomics, Numer 19/1, 2018, Strona(/y) 37-58, ISSN 1471-2164
Wydawca: BioMed Central
DOI: 10.1186/s12864-017-4375-1

Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability

Autorzy: Panagiotis Galanos, George Pappas, Alexander Polyzos, Athanassios Kotsinas, Ioanna Svolaki, Nickolaos N. Giakoumakis, Christina Glytsou, Ioannis S. Pateras, Umakanta Swain, Vassilis L. Souliotis, Alexandros G. Georgakilas, Nicholas Geacintov, Luca Scorrano, Claudia Lukas, Jiri Lukas, Zvi Livneh, Zoi Lygerou, Dipanjan Chowdhury, Claus Storgaard Sørensen, Jiri Bartek, Vassilis G. Gorgoulis
Opublikowane w: Genome Biology, Numer 19/1, 2018, ISSN 1474-760X
Wydawca: Genome Biology
DOI: 10.1186/s13059-018-1401-9

BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors

Autorzy: Timo Reisländer, Emilia Puig Lombardi, Florian J. Groelly, Ana Miar, Manuela Porru, Serena Di Vito, Benjamin Wright, Helen Lockstone, Annamaria Biroccio, Adrian Harris, Arturo Londoño-Vallejo, Madalena Tarsounas
Opublikowane w: Nature Communications, Numer 10/1, 2019, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-019-11048-5

Integrating the DNA damage and protein stress responses during cancer development and treatment

Autorzy: Vassilis G Gorgoulis, Dafni-Eleftheria Pefani, Ioannis S Pateras, Ioannis P Trougakos
Opublikowane w: The Journal of Pathology, Numer 246/1, 2018, Strona(/y) 12-40, ISSN 0022-3417
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/path.5097

Targeting BER enzymes in cancer therapy

Autorzy: Torkild Visnes, Maurice Grube, Bishoy Magdy Fekry Hanna, Carlos Benitez-Buelga, Armando Cázares-Körner, Thomas Helleday
Opublikowane w: DNA Repair, Numer 71, 2018, Strona(/y) 118-126, ISSN 1568-7864
Wydawca: Elsevier BV
DOI: 10.1016/j.dnarep.2018.08.015

Senescence and senotherapeutics: a new field in cancer therapy

Autorzy: Vassilios Myrianthopoulos, Konstantinos Evangelou, Panagiotis V.S. Vasileiou, Tomer Cooks, Theodoros P. Vassilakopoulos, Gerassimos A. Pangalis, Myrsini Kouloukoussa, Christos Kittas, Alexandros G. Georgakilas, Vassilis G. Gorgoulis
Opublikowane w: Pharmacology & Therapeutics, Numer 193, 2019, Strona(/y) 31-49, ISSN 0163-7258
Wydawca: Pergamon Press
DOI: 10.1016/j.pharmthera.2018.08.006

A Deep Learning Framework for Predicting Response to Therapy in Cancer

Autorzy: Theodore Sakellaropoulos, Konstantinos Vougas, Sonali Narang, Filippos Koinis, Athanassios Kotsinas, Alexander Polyzos, Tyler J. Moss, Sarina Piha-Paul, Hua Zhou, Eleni Kardala, Eleni Damianidou, Leonidas G. Alexopoulos, Iannis Aifantis, Paul A. Townsend, Mihalis I. Panayiotidis, Petros Sfikakis, Jiri Bartek, Rebecca C. Fitzgerald, Dimitris Thanos, Kenna R. Mills Shaw, Russell Petty, Aristotelis T
Opublikowane w: Cell Reports, Numer 29/11, 2019, Strona(/y) 3367-3373.e4, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2019.11.017

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