Establishment and maintenance of gene expression by heterochromatin factors

Project Information

METACHROM

Grant agreement ID: 724835

DOI 10.3030/724835

Project closed

EC signature date 24 April 2017

Start date 1 June 2017

End date 30 November 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 025,00

EU contribution € 1 999 025,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

Publications

Peer reviewed articles (9)

SETDB1/NSD-dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers

Author(s): Amandine Barral; Gabrielle Pozo; Lucas Ducrot; Giorgio L. Papadopoulos; Sandrine Sauzet; Andrew J. Oldfield; Giacomo Cavalli; Jérôme Déjardin
Published in: Molecular Cell, Issue 6, 2022, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2021.12.037

Telomere chromatin establishment and its maintenance during mammalian development

Author(s): Mathieu Tardat, Jérôme Déjardin
Published in: Chromosoma, Issue 127/1, 2018, Page(s) 3-18, ISSN 0009-5915
Publisher: Springer Verlag
DOI: 10.1007/s00412-017-0656-3

Integrative Proteomic Profiling Reveals PRC2-Dependent Epigenetic Crosstalk Maintains Ground-State Pluripotency

Author(s): Guido van Mierlo, René A.M. Dirks, Laura De Clerck, Arie B. Brinkman, Michelle Huth, Susan L. Kloet, Nehmé Saksouk, Leonie I. Kroeze, Sander Willems, Matthias Farlik, Christoph Bock, Joop H. Jansen, Dieter Deforce, Michiel Vermeulen, Jérôme Déjardin, Maarten Dhaenens, Hendrik Marks
Published in: Cell Stem Cell, Issue 24/1, 2019, Page(s) 123-137.e8, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2018.10.017

SETDB1-dependent heterochromatin stimulates alternative lengthening of telomeres

Author(s): Mathilde Gauchier, Sophie Kan, Amandine Barral, Sandrine Sauzet, Eneritz Agirre, Erin Bonnell, Nehmé Saksouk, Teresa K. Barth, Satoru Ide, Serge Urbach, Raymund J. Wellinger, Reini F. Luco, Axel Imhof, Jérôme Déjardin
Published in: Science Advances, Issue 5/5, 2019, Page(s) eaav3673, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.aav3673

Remodeling and destabilization of chromosome 1 pericentromeric heterochromatin by SSX proteins

Author(s): Sofie Traynor, Niels Erik Møllegaard, Mikkel G Jørgensen, Nadine H Brückmann, Christina B Pedersen, Mikkel G Terp, Simone Johansen, Jerome Dejardin, Henrik J Ditzel, Morten F Gjerstorff
Published in: Nucleic Acids Research, Issue 47/13, 2019, Page(s) 6668-6684, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkz396

SMCHD1 is involved in de novo methylation of the DUX4 -encoding D4Z4 macrosatellite

Author(s): Camille Dion, Stéphane Roche, Camille Laberthonnière, Natacha Broucqsault, Virginie Mariot, Shifeng Xue, Alexandra D Gurzau, Agnieszka Nowak, Christopher T Gordon, Marie-Cécile Gaillard, Claire El-Yazidi, Morgane Thomas, Andrée Schlupp-Robaglia, Chantal Missirian, Valérie Malan, Liham Ratbi, Abdelaziz Sefiani, Bernd Wollnik, Bernard Binetruy, Emmanuelle Salort Campana, Shahram Attarian, Rafa
Published in: Nucleic Acids Research, Issue 47/6, 2019, Page(s) 2822-2839, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkz005

Purification and enrichment of specific chromatin loci

Author(s): Mathilde Gauchier, Guido van Mierlo, Michiel Vermeulen, Jérôme Déjardin
Published in: Nature Methods, Issue 17/4, 2020, Page(s) 380-389, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-020-0765-4

Telomeric Chromatin and TERRA

Author(s): Amandine Barral, Jérome Déjardin
Published in: Journal of Molecular Biology, Issue 432/15, 2020, Page(s) 4244-4256, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2020.03.003

The chromatin signatures of enhancers and their dynamic regulation

Author(s): Amandine Barral; Jérôme Déjardin
Published in: Nucleus, Issue 5, 2023, ISSN 1949-1034
Publisher: Landes Bioscience
DOI: 10.1080/19491034.2022.2160551

Non-peer reviewed articles (1)

Locus-specific chromatin isolation

Author(s): Michiel Vermeulen, Jérôme Déjardin
Published in: Nature Reviews Molecular Cell Biology, Issue 21/5, 2020, Page(s) 249-250, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-020-0217-0