Objectif The first behavioural theories conceived the organism as primarily driven by external sensory stimuli. However, the energy associated with momentary demands of the environment represent ~1% of the brain's total energy budget, implying that the intrinsic activity represents a major aspect of the brain's function. Indeed, more recent theories such as cognitivism and embodiment describe the organisms as capable of generating complex behaviours emerging from the brain's intrinsic dynamics. Past and current studies that investigated the neuronal basis self-generated behaviours mainly focus on the readiness potential (RP) signal, a build-up ramping activity in the premotor cortex, occurring ~ 2 sec before the movement's onset. However, the neuronal mechanisms underlying the generation of self-generated behaviours (how RPs are generated), the involvement of other regions, and how the brain codes the impending movements (activity predictive of the onset and type of movement), still remain poorly understood.The combination of light-sheet microscopy, optogenetics, and the zebrafish larva model enables monitoring whole-brain dynamics in an intact behaving vertebrate. Moreover, the diverse yet limited and well described repertoire of motor behaviours will enable to perform experiments in more natural unconstrained conditions, in comparison to previous studies, which were structured in trials and limited to one or two behavioural choices. These advantages will allow us to go beyond the current state-of-the-art in the field. More specifically, we propose to investigate the following specific aims:1) Whole-brain dynamics basis and mechanisms underlying self-generated behaviours.2) A comparison between the neuronal pathways underlying the initiation of self-generated and sensory induced behaviours.3) The internal and external modulation of self-generated behaviours. Champ scientifique natural sciencesphysical sciencesopticsmicroscopy Mots‑clés Neuronal circuit dynamics SPIM zebrafish optogenetics behaviour internal decisions computational neuroscience calcium imaging Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Thème(s) ERC-2016-COG - ERC Consolidator Grant Appel à propositions ERC-2016-COG Voir d’autres projets de cet appel Régime de financement ERC-COG - Consolidator Grant Institution d’accueil INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Contribution nette de l'UE € 1 922 360,00 Adresse RUE DE TOLBIAC 101 75654 Paris France Voir sur la carte Région Ile-de-France Ile-de-France Paris Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 1 997 360,00 Bénéficiaires (2) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France Contribution nette de l'UE € 1 922 360,00 Adresse RUE DE TOLBIAC 101 75654 Paris Voir sur la carte Région Ile-de-France Ile-de-France Paris Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 1 997 360,00 Tiers Entité juridique autre qu’un sous-traitant qui est affiliée ou juridiquement liée à un participant. L’entité réalise des travaux dans les conditions prévues par la convention de subvention, fournit des biens ou des services pour l’action, mais n’a pas signé la convention de subvention. Le tiers respecte les règles applicables au participant qui lui est lié dans le cadre de la convention de subvention en ce qui concerne l’éligibilité des coûts et le contrôle des dépenses. ECOLE NORMALE SUPERIEURE France Contribution nette de l'UE € 75 000,00 Adresse 45, RUE D'ULM 75230 Paris Voir sur la carte Région Ile-de-France Ile-de-France Paris Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 75 000,00