Objectif
The crucial question is how much higher the incidence of obstructive respiratory disease is in miners underground whose bronchial system has been proved to be hypersensitive by the methacholine provocation test and how bronchial hypersensitivity, once ascertained, develops over the long term.
In the next four years 1400 miners are to be examined in the course of the regular two-yearly medicals. The clinical examination is - as previously - to be carried out using the standardized questionnaire.
METHODS AND MEANS BY WHICH THE AIMS ARE TO BE ACHIEVED
Whole-body plethysmographic measurements of the airway resistance and the intrathoracic gas volume are to be taken, an inhalation concentration test with 0.35% methacholine solution and a spirometric test of the VC, FVC, FEV1 and the flow-volume curve (MEF 75, MEF 50 and MEF 25) are to be carried out an all the subjects. The results will be analysed by a central computer using specially developed software.
Thème(s)
Data not availableAppel à propositions
Data not availableRégime de financement
CSC - Cost-sharing contractsCoordinateur
44789 BOCHUM
Allemagne