Cel The project sets out to develop and validate a dosimetric model relating to the "harmfulness" associated with inhaling coalmine dusts. Its purpose is to provide a quantitative, scientific basis for risk assessment, standards setting, design of sampling strategies and hazard control. This model, obtained from animal studies, will be validated by reference to the known epidemiology of chest illness among mineworkers.The work involves compiling the information already available on: a) the physical behaviour of airborne particles and their entry into the respiratory tract during breathing. b) the kinetics of their deposition, distribution, clearance and storage; c) the kinetics of the biological responses to the presence of particles in the lung; d) the pathology and particulate burdens of lungs removed from people post-mortem; and e) the epidemiological evidence linking dust-related diseases with occupational exposure histories of working populations. METHODS AND MEANS BY WHICH THE AIMS ARE TO BE ACHIEVEDThe main thrust of the project involves an exercise in mathematical modelling and statistics, using data (and other information) drawn from wide-ranging studies. For this research, the required computing and database facilities and statistical software are already in place. One piece of additional experimental work is required to complete the data set required for development of the desired dosimetric model: namely, the cell responses to relevant coalmine dusts in a form suitable for application in the dosimetric rationale. Program(-y) ECSC-MEDRES 5C - Fifth medical research programme (ECSC) "Protection of workers against risks arising from work in the coal and steel industries", 1988-1992 Temat(-y) Data not available Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator Institute of Occupational Medicine Wkład UE Brak danych Adres 8 Roxburgh Place EH8 9SU Edinburgh Zjednoczone Królestwo Zobacz na mapie Koszt całkowity Brak danych
