Mechanical control of biological function

Rezultaty

Plan for the Exploitation and Dissemination of Results
Characterization of mechanical and adhesive factors driving sub-cellular behaviour

Characterization of mechanical and adhesive factors driving sub-cellular behaviour, plus publication

Updated Plan for the Exploitation and Dissemination of Results M12

Update the Plan for the Exploitation and Dissemination of Results

Characterization of mechanical and adhesive factors driving cellular behaviour

Characterization of mechanical and adhesive factors driving cellular behaviour, plus publication.

Updated Plan for the Exploitation and Dissemination of Results M48

Update the Plan for the Exploitation and Dissemination of Results

Proof of concept tested and publication: human breast cancer xenografts can be treated/controlled by controlling tissue mechanics

Proof of concept tested and publication human breast cancer xenografts can be treatedcontrolled by controlling tissue mechanics

Proof of concept tested and publication: transplantation-based syngeneic mouse breast cancer model can be treated/controlled by controlling tissue mechanics

Proof of concept tested and publication transplantationbased syngeneic mouse breast cancer model can be treatedcontrolled by controlling tissue mechanics

Updated Plan for the Exploitation and Dissemination of Results M30

Update the Plan for the Exploitation and Dissemination of Results

Proof of concept tested and publication: mechanical-control can enhance the efficacy of current breast cancer treatments

Proof of concept tested and publication mechanicalcontrol can enhance the efficacy of current breast cancer treatments

Updated Plan for the Exploitation and Dissemination of Results M60

Update the Plan for the Exploitation and Dissemination of Results

Characterization of mechanical and adhesive factors driving monolayer behaviour

Characterization of mechanical and adhesive factors driving monolayer behaviour plus publication

Characterization of mechanical and adhesive factors driving organoid behaviour

Characterization of mechanical and adhesive factors driving organoid behaviour plus publication

Set-up of the continuum model coupling adhesion, cortex, membrane and matrix
Set-up of the specific validation experiments for bond clusters, and Predictive models for the lifetime of a cluster
Set-up of the discrete stochastic models for bond clusters

Summer school
Logo and Public website of the project
Mechanobiology Meeting

Publikacje

Epithelial cell cluster size affects force distribution in response to EGF-induced collective contractility

Autorzy: Chiara Zambarda, Carlos Perez Gonzalez, Andreas Schoenit, Nisha Veits, Clara Schimmer, Raimund Jung, Dirk Ollech, Joel Christian, Pere Roca-Cusachs, Xavier Trepat , Elisabetta Ada Cavalcanti-Adam
Opublikowane w: European Journal of Cell Biology, 2022, ISSN 0171-9335
Wydawca: Elsevier BV
DOI: 10.1016/j.ejcb.2022.151274

Caveolin-1 dolines form a distinct and rapid caveolae-independent mechanoadaptation system

Autorzy: Lolo FN, Walani N, Seemann E, Zalvidea D, Pavón DM, Cojoc G, Zamai M, Viaris de Lesegno C, Martínez de Benito F, Sánchez-Álvarez M, Uriarte JJ, Echarri A, Jiménez-Carretero D, Escolano JC, Sánchez SA, Caiolfa VR, Navajas D, Trepat X, Guck J, Lamaze C, Roca-Cusachs P, Kessels MM, Qualmann B, Arroyo M, Del Pozo MA.
Opublikowane w: Nature Cell Biology, 2022, ISSN 1465-7392
Wydawca: Nature Publishing Group
DOI: 10.1038/s41556-022-01034-3

Digesting the mechanobiology of the intestinal epithelium

Autorzy: Carlos Pérez-González, Gerardo Ceada, Marija Matejčić, Xavier Trepat
Opublikowane w: Current Opinion in Genetics & Development, 2021, ISSN 0959-437X
Wydawca: Elsevier BV
DOI: 10.1016/j.gde.2021.10.005

Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina

Autorzy: Pedro Barbacena, Maria Dominguez-Cejudo, Catarina G. Fonseca, Manuel Gomez-Gonzalez, Laura M. Faure, Georgia Zarkada, Andreia Pena, Anna Pezzarossa, Daniela Ramalho, Ylenia Giarratano, Marie Ouarne, David Barata, Isabela C. Fortunato, Lenka Henao Misikova, Ian Mauldin, Yulia Carvalho, Xavier Trepat, Pere Roca-Cusachs, Anne Eichmann, Miguel O. Bernabeu, and Claudio A. Franco
Opublikowane w: Developmental Cell, 2022, ISSN 1534-5807
Wydawca: Cell Press
DOI: 10.1016/j.devcel.2022.09.002

Dynamic mechanochemical feedback between curved membranes and BAR protein self-organization

Autorzy: Anabel-Lise Le Roux, Caterina Tozzi, Nikhil Walani, Xarxa Quiroga, Dobryna Zalvidea, Xavier Trepat, Margarita Staykova, Marino Arroyo & Pere Roca-Cusachs
Opublikowane w: Nature Communications, 2021, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-26591-3

Thiol-Methylsulfone-Based Hydrogels for 3D Cell Encapsulation

Autorzy: Julieta I. Paez, Aleeza Farrukh, Rocío Valbuena-Mendoza, Małgorzata K. Włodarczyk-Biegun, Aránzazu del Campo
Opublikowane w: ACS Applied Materials & Interfaces, Numer 12/7, 2020, Strona(/y) 8062-8072, ISSN 1944-8244
Wydawca: American Chemical Society
DOI: 10.1021/acsami.0c00709

Positive, negative and controlled durotaxis

Autorzy: Sáez Viñas, Pablo; Venturini, Chiara
Opublikowane w: Soft Matter, 2023, ISSN 1744-683X
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d2sm01326f

Cardiac fibroblasts and mechanosensation in heart development, health and disease

Autorzy: Maurizio Pesce, Georg N. Duda, Giancarlo Forte, Henrique Girao, Angel Raya, Pere Roca-Cusachs, Joost P. G. Sluijter, Carsten Tschöpe & Sophie Van Linthout
Opublikowane w: Nature Review Cardiology, 2022, ISSN 1759-5002
Wydawca: Nature Publishing Group
DOI: 10.1038/s41569-022-00799-2

Stiffness-dependent active wetting enables optimal collective cell durotaxis

Autorzy: Macià Esteve Pallarès, Irina Pi-Jaumà, Isabela Corina Fortunato, Valeria Grazu, Manuel Gómez-González, Pere Roca-Cusachs, Jesus M. de la Fuente, Ricard Alert, Raimon Sunyer, Jaume Casademunt & Xavier Trepat
Opublikowane w: Nature Physics, 2022, ISSN 1745-2473
Wydawca: Nature Publishing Group
DOI: 10.1038/s41567-022-01835-1

An asymmetric junctional mechanoresponse coordinates mitotic rounding with epithelial integrity

Autorzy: Jooske L. Monster, Lisa Donker, Marjolein J. Vliem, Zaw Win, Helen K. Matthews, Joleen S. Cheah, Soichiro Yamada, Johan de Rooij, Buzz Baum, Martijn Gloerich
Opublikowane w: Journal of Cell Biology, Numer 220/5, 2021, ISSN 0021-9525
Wydawca: Rockefeller University Press
DOI: 10.1083/jcb.202001042

Active wetting of epithelial tissues

Autorzy: Carlos Pérez-González, Ricard Alert, Carles Blanch-Mercader, Manuel Gómez-González, Tomasz Kolodziej, Elsa Bazellieres, Jaume Casademunt, Xavier Trepat
Opublikowane w: Nature Physics, Numer 15/1, 2019, Strona(/y) 79-88, ISSN 1745-2473
Wydawca: Nature Publishing Group
DOI: 10.1038/s41567-018-0279-5

Peeling dynamics of fluid membranes bridged by molecular bonds: moving or breaking

Autorzy: Dimitri Kaurin, Pradeep K. Bal, Marino Arroyo
Opublikowane w: Journal of the Royal Society Interface, 2022, ISSN 1742-5689
Wydawca: The Royal Society
DOI: 10.1098/rsif.2022.0183

Mechanical force application to the nucleus regulates nucleocytoplasmic transport

Autorzy: Ion Andreu, Ignasi Granero-Moya, Nimesh R. Chahare, Kessem Clein, Marc Molina-Jordán, Amy E. M. Beedle, Alberto Elosegui-Artola, Juan F. Abenza, Leone Rossetti, Xavier Trepat, Barak Raveh, Pere Roca-Cusachs
Opublikowane w: Nature Cell Biology, 2022, ISSN 1465-7392
Wydawca: Nature Publishing Group
DOI: 10.1038/s41556-022-00927-7

A theory of ordering of elongated and curved proteins on membranes driven by density and curvature

Autorzy: Caterina Tozzi, Nikhil Walani, Anabel-Lise Le Roux, Pere Roca-Cusachs, Marino Arroyo
Opublikowane w: Soft Matter, Numer 17/12, 2021, Strona(/y) 3367-3379, ISSN 1744-683X
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d0sm01733g

Thiol-Methylsulfone-Based Hydrogels for Cell Encapsulation: Reactivity Optimization of Aryl-Methylsulfone Substrate for Fine-Tunable Gelation Rate and Improved Stability

Autorzy: Julieta I. Paez, Adrián de Miguel-Jiménez, Rocío Valbuena-Mendoza, Aditi Rathore, Minye Jin, Alisa Gläser, Samuel Pearson, Aránzazu del Campo
Opublikowane w: Biomacromolecules, 2021, ISSN 0002-7863
Wydawca: American Chemical Society
DOI: 10.1021/acs.biomac.1c00256

Molecular Fluctuations as a Ruler of Force-Induced Protein Conformations

Autorzy: Andrew Stannard, Marc Mora, Amy E. M. Beedle, Marta Castro-López, Stephanie Board, Sergi Garcia-Manyes
Opublikowane w: Nano Letters, Numer 21/7, 2021, Strona(/y) 2953-2961, ISSN 1530-6984
Wydawca: American Chemical Society
DOI: 10.1021/acs.nanolett.1c00051

TLN1 contains a cancer-associated cassette exon that alters talin-1 mechanosensitivity

Autorzy: Gallego-Paez, L. M., Edwards, W. J. S., Chanduri, M., Guo, Y., Koorman, T., Lee, C. Y., Grexa, N., Derksen, P., Yan, J., Schwartz, M. A., Mauer, J., & Goult, B. T.
Opublikowane w: Journal of Cell Biology, 2023, ISSN 0021-9525
Wydawca: Rockefeller University Press
DOI: 10.1083/jcb.202209010

Mechanical strain stimulates COPII‐dependent secretory trafficking via Rac1

Autorzy: Santosh Phuyal, Elena Djaerff, Anabel-Lise Le Roux, Martin J Baker, Daniela Fankhauser, Sayyed Jalil Mahdizadeh, Veronika Reiterer, Amirabbas Parizadeh, Edward Felder,Jennifer C Kahlhofer, David Teis, Marcelo G Kazanietz, Stephan Geley, Leif Eriksson, Pere Roca-Cusachs & Hesso Farhan
Opublikowane w: EMBO Journal, 2022, ISSN 1460-2075
Wydawca: Wiley-Blackwell
DOI: 10.15252/embj.2022110596

Atlas of Lobular Breast Cancer Models: Challenges and Strategic Directions

Autorzy: George Sflomos, Koen Schipper, Thijs Koorman, Amanda Fitzpatrick, Steffi Oesterreich, Adrian V. Lee, Jos Jonkers, Valerie G. Brunton, Matthias Christgen, Clare Isacke, Patrick W. B. Derksen, and Cathrin Brisken
Opublikowane w: Cancers, 2021, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13215396

Optoregulated force application to cellular receptors using molecular motors

Autorzy: Yijun Zheng, Mitchell K. L. Han, Renping Zhao, Johanna Blass, Jingnan Zhang, Dennis W. Zhou, Jean-Rémy Colard-Itté, Damien Dattler, Arzu Çolak, Markus Hoth, Andrés J. García, Bin Qu, Roland Bennewitz, Nicolas Giuseppone & Aránzazu del Campo
Opublikowane w: Nature Communications, 2021, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-23815-4

SKOR1 mediates FER kinase-dependent invasive growth of breast cancer cells

Autorzy: Sluimer, L. M., Bullock, E., Rätze, M. A. K., Enserink, L., Overbeeke, C., Hornsveld, M., Brunton, V. G., Derksen, P. W. B., & Tavares, S.
Opublikowane w: Journal of cell science, 2023, ISSN 0021-9533
Wydawca: The Company of Biologists Ltd.
DOI: 10.1242/jcs.260243

Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration

Autorzy: Pérez-González C; Ceada G; Greco F; Matej?i? M; Gómez-González M; Castro N; Menendez A; Kale S; Krndija D; Clark AG; Gannavarapu VR; Álvarez-Varela A; Roca-Cusachs P; Batlle E; Vignjevic DM; Arroyo M; Trepat X
Opublikowane w: Nature Cell Biology, 2021, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41556-021-00699-6

The ESCRT machinery counteracts Nesprin-2G-mediated mechanical forces during nuclear envelope repair

Autorzy: Wallis SS, Ventimiglia, LN, Otigbah E, Infante E, Cuesta-Geijo MA, Kidiyoor GR, Carbajal MA, Fleck RA, Foiani M, Garcia-Manyes S, Martin-Serrano J, Agromayor M
Opublikowane w: Developmental Cell, 2021, ISSN 1534-5807
Wydawca: Cell Press
DOI: 10.1016/j.devcel.2021.10.022

Understanding the role of mechanics in nucleocytoplasmic transport

Autorzy: Ion Andreu, Ignasi Granero-Moya, Sergi Garcia-Manyes and Pere Roca-Cusachs
Opublikowane w: APL Bioengineering, 2022, ISSN 2473-2877
Wydawca: American Institute of Physics
DOI: 10.1063/5.0076034

Out-of-equilibrium mechanochemistry and self-organization of fluid membranes interacting with curved proteins

Autorzy: Caterina Tozzi, Nikhil Walani, Marino Arroyo
Opublikowane w: New Journal of Physics, Numer 21/9, 2019, Strona(/y) 093004, ISSN 1367-2630
Wydawca: Institute of Physics Publishing
DOI: 10.1088/1367-2630/ab3ad6

Loss of E-cadherin leads to Id2-dependent inhibition of cell cycle progression in metastatic lobular breast cancer

Autorzy: Max A. K. Rätze, Thijs Koorman, Thijmen Sijnesael, Blessing Bassey-Archibong, Robert van de Ven, Lotte Enserink, Daan Visser, Sridevi Jaksani, Ignacio Viciano, Elvira R. M. Bakker, François Richard, Andrew Tutt, Lynda O’Leary, Amanda Fitzpatrick, Pere Roca-Cusachs, Paul J. van Diest, Christine Desmedt, Juliet M. Daniel, Clare M. Isacke and Patrick W. B. Derksen
Opublikowane w: Oncogene, 2022, ISSN 0950-9232
Wydawca: Nature Publishing Group
DOI: 10.1038/s41388-022-02314-w

Surface Tension Controls the Hydraulic Fracture of Adhesive Interfaces Bridged by Molecular Bonds

Autorzy: Dimitri Kaurin, Marino Arroyo
Opublikowane w: Physical Review Letters, Numer 123/22, 2019, ISSN 0031-9007
Wydawca: American Physical Society
DOI: 10.1103/physrevlett.123.228102

Modelling fluid deformable surfaces with an emphasis on biological interfaces

Autorzy: Alejandro Torres-Sánchez, Daniel Millán, Marino Arroyo
Opublikowane w: Journal of Fluid Mechanics, Numer 872, 2019, Strona(/y) 218-271, ISSN 0022-1120
Wydawca: Cambridge University Press
DOI: 10.1017/jfm.2019.341

Binding of anisotropic curvature-inducing proteins onto membrane tubes

Autorzy: Hiroshi Noguchi, Caterina Tozzi and Marino Arroyo
Opublikowane w: Soft Matter, 2022, ISSN 1744-683X
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d2sm00274d

Force transduction by cadherin adhesions in morphogenesis

Autorzy: Willem-Jan Pannekoek, Johan de Rooij, Martijn Gloerich
Opublikowane w: F1000Research, Numer 8, 2019, Strona(/y) 1044, ISSN 2046-1402
Wydawca: F1000 Research Ltd.
DOI: 10.12688/f1000research.18779.1

The 2020 motile active matter roadmap

Autorzy: Gerhard Gompper, Roland G Winkler, Thomas Speck, Alexandre Solon, Cesare Nardini, Fernando Peruani, Hartmut Löwen, Ramin Golestanian, U Benjamin Kaupp, Luis Alvarez, Thomas Kiørboe, Eric Lauga, Wilson C K Poon, Antonio DeSimone, Santiago Muiños-Landin, Alexander Fischer, Nicola A Söker, Frank Cichos, Raymond Kapral, Pierre Gaspard, Marisol Ripoll, Francesc Sagues, Amin Doostmohammadi, Julia M
Opublikowane w: Journal of Physics: Condensed Matter, Numer 32/19, 2020, Strona(/y) 193001, ISSN 0953-8984
Wydawca: Institute of Physics Publishing
DOI: 10.1088/1361-648x/ab6348

The mechanics of single cross-links which mediate cell attachment at a hydrogel surface

Autorzy: Arzu Çolak, Bin Li, Johanna Blass, Kaloian Koynov, Aranzazu del Campo, Roland Bennewitz
Opublikowane w: Nanoscale, Numer 11/24, 2019, Strona(/y) 11596-11604, ISSN 2040-3364
Wydawca: Royal Society of Chemistry
DOI: 10.1039/c9nr01784d

Photodegradable Hydrogels for Cell Encapsulation and Tissue Adhesion

Autorzy: Maria Villiou, Julieta I. Paez, Aránzazu del Campo
Opublikowane w: ACS Applied Materials & Interfaces, Numer 12/34, 2020, Strona(/y) 37862-37872, ISSN 1944-8244
Wydawca: American Chemical Society
DOI: 10.1021/acsami.0c08568

Rethinking organoid technology through bioengineering

Autorzy: Elena Garreta, Roger D. Kamm, Susana M. Chuva de Sousa Lopes, Madeline A. Lancaster, Ron Weiss, Xavier Trepat, Insoo Hyun, Nuria Montserrat
Opublikowane w: Nature Materials, Numer 20/2, 2021, Strona(/y) 145-155, ISSN 1476-1122
Wydawca: Nature Publishing Group
DOI: 10.1038/s41563-020-00804-4

4D hydrogel for dynamic cell culture with orthogonal, wavelength-dependent mechanical and biochemical cues

Autorzy: Yijun Zheng, Mitchell Kim Liong Han, Qiyang Jiang, Bin Li, Jun Feng, Aránzazu del Campo
Opublikowane w: Materials Horizons, Numer 7/1, 2020, Strona(/y) 111-116, ISSN 2051-6347
Wydawca: Royal Society of Chemistry
DOI: 10.1039/c9mh00665f

Spatial collagen stiffening promotes collective breast cancer cell invasion by reinforcing extracellular matrix alignment

Autorzy: Thijs Koorman, Karin A. Jansen, Antoine Khalil, Peter D. Haughton, Daan Visser, Max A. K. Rätze, Wisse E. Haakma, Gabrielè Sakalauskaitè, Paul J. van Diest, Johan de Rooij and Patrick W. B. Derksen
Opublikowane w: Oncogene, 2022, ISSN 0950-9232
Wydawca: Nature Publishing Group
DOI: 10.1038/s41388-022-02258-1

Toward Light-Regulated Living Biomaterials

Autorzy: Shrikrishnan Sankaran, Shifang Zhao, Christina Muth, Julieta Paez, Aránzazu del Campo
Opublikowane w: Advanced Science, Numer 5/8, 2018, Strona(/y) 1800383, ISSN 2198-3844
Wydawca: Wiley-VCH
DOI: 10.1002/advs.201800383

The nanomechanics of individual proteins

Autorzy: Marc Mora, Andrew Stannard, Sergi Garcia-Manyes
Opublikowane w: Chemical Society Reviews, Numer 49/19, 2020, Strona(/y) 6816-6832, ISSN 0306-0012
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d0cs00426j

Self-generated gradients steer collective migration on viscoelastic collagen networks

Autorzy: Andrew G. Clark, Ananyo Maitra, Cécile Jacques , Martin Bergert , Carlos Pérez-González, Anthony Simon, Luc Lederer , Alba Diz-Muñoz, Xavier Trepat, Raphaël Voituriez, Danijela Matic Vignjevic
Opublikowane w: Nature materials, 2022, ISSN 1476-1122
Wydawca: Nature Publishing Group
DOI: 10.1038/s41563-022-01259-5

Exogenous supply of Hsp47 triggers fibrillar collagen deposition in skin cell cultures in vitro

Autorzy: Essak S. Khan, Shrikrishnan Sankaran, Lorena Llontop, Aránzazu del Campo
Opublikowane w: BMC Molecular and Cell Biology, Numer 21/1, 2020, ISSN 2661-8850
Wydawca: BioMed Central Ltd
DOI: 10.1186/s12860-020-00267-0

FER regulates endosomal recycling and is a predictor for adjuvant taxane benefit in breast cancer

Autorzy: Sandra Tavares, Nalan Liv, Milena Pasolli, Mark Opdam, Max A.K. Rätze, Manuel Saornil, Lilian M. Sluimer, Rutger C.C. Hengeveld, Robert van Es, Erik van Werkhoven, Harmjan Vos, Holger Rehmann, Boudewijn M.T. Burgering, Hendrika M. Oosterkamp, Susanne M.A. Lens, Judith Klumperman, Sabine C. Linn, Patrick W.B. Derksen
Opublikowane w: Cell reports, 2022, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2022.110584

αE-catenin is a candidate tumor suppressor for the development of E-cadherin-expressing lobular-type breast cancer

Autorzy: Jolien S de Groot, Max AK Ratze, Miranda van Amersfoort, Tanja Eisemann, Eva J Vlug, Mijanou T Niklaas, Suet-Feung Chin, Carlos Caldas, Paul J van Diest, Jos Jonkers, Johan de Rooij, Patrick WB Derksen
Opublikowane w: The Journal of Pathology, Numer 245/4, 2018, Strona(/y) 456-467, ISSN 0022-3417
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/path.5099

Near-infrared-light regulated angiogenesis in a 4D hydrogel

Autorzy: Yijun Zheng, Zhijun Chen, Qiyang Jiang, Jun Feng, Si Wu, Aránzazu del Campo
Opublikowane w: Nanoscale, Numer 12/25, 2020, Strona(/y) 13654-13661, ISSN 2040-3364
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d0nr02552f

Physical Models of Collective Cell Migration

Autorzy: Ricard Alert, Xavier Trepat
Opublikowane w: Annual Review of Condensed Matter Physics, Numer 11/1, 2020, Strona(/y) 77-101, ISSN 1947-5454
Wydawca: Annual Reviews Inc.
DOI: 10.1146/annurev-conmatphys-031218-013516

Long-lived force patterns and deformation waves at repulsive epithelial boundaries

Autorzy: Pilar Rodríguez-Franco, Agustí Brugués, Ariadna Marín-Llauradó, Vito Conte, Guiomar Solanas, Eduard Batlle, Jeffrey J. Fredberg, Pere Roca-Cusachs, Raimon Sunyer, Xavier Trepat
Opublikowane w: Nature Materials, Numer 16/10, 2017, Strona(/y) 1029-1037, ISSN 1476-1122
Wydawca: Nature Publishing Group
DOI: 10.1038/NMAT4972

Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores

Autorzy: Alberto Elosegui-Artola, Ion Andreu, Amy E.M. Beedle, Ainhoa Lezamiz, Marina Uroz, Anita J. Kosmalska, Roger Oria, Jenny Z. Kechagia, Palma Rico-Lastres, Anabel-Lise Le Roux, Catherine M. Shanahan, Xavier Trepat, Daniel Navajas, Sergi Garcia-Manyes, Pere Roca-Cusachs
Opublikowane w: Cell, Numer 171/6, 2017, Strona(/y) 1397-1410.e14, ISSN 0092-8674
Wydawca: Cell Press
DOI: 10.1016/j.cell.2017.10.008

Membrane tension controls adhesion positioning at the leading edge of cells

Autorzy: Bruno Pontes, Pascale Monzo, Laurent Gole, Anabel-Lise Le Roux, Anita Joanna Kosmalska, Zhi Yang Tam, Weiwei Luo, Sophie Kan, Virgile Viasnoff, Pere Roca-Cusachs, Lisa Tucker-Kellogg, Nils C. Gauthier
Opublikowane w: The Journal of Cell Biology, 2017, Strona(/y) jcb.201611117, ISSN 0021-9525
Wydawca: Rockefeller University Press
DOI: 10.1083/jcb.201611117

Force loading explains spatial sensing of ligands by cells

Autorzy: Roger Oria, Tina Wiegand, Jorge Escribano, Alberto Elosegui-Artola, Juan Jose Uriarte, Cristian Moreno-Pulido, Ilia Platzman, Pietro Delcanale, Lorenzo Albertazzi, Daniel Navajas, Xavier Trepat, José Manuel García-Aznar, Elisabetta Ada Cavalcanti-Adam, Pere Roca-Cusachs
Opublikowane w: Nature, 2017, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/nature24662

Binding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1–fibronectin links

Autorzy: Víctor González-Tarragó, Alberto Elosegui-Artola, Elsa Bazellières, Roger Oria, Carlos Pérez-González, Pere Roca-Cusachs
Opublikowane w: Molecular Biology of the Cell, Numer 28/14, 2017, Strona(/y) 1847-1852, ISSN 1059-1524
Wydawca: American Society for Cell Biology
DOI: 10.1091/mbc.E17-01-0006

Amoebae as Mechanosensitive Tanks

Autorzy: Alberto Elosegui-Artola, Pere Roca-Cusachs
Opublikowane w: Biophysical Journal, Numer 112/12, 2017, Strona(/y) 2457-2458, ISSN 0006-3495
Wydawca: Biophysical Society
DOI: 10.1016/j.bpj.2017.05.020

The force-dependent mechanism of DnaK-mediated mechanical folding

Autorzy: Judit Perales-Calvo, David Giganti, Guillaume Stirnemann, Sergi Garcia-Manyes
Opublikowane w: Science Advances, Numer 4/2, 2018, Strona(/y) eaaq0243, ISSN 2375-2548
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/sciadv.aaq0243

Quantifying forces in cell biology

Autorzy: Pere Roca-Cusachs, Vito Conte, Xavier Trepat
Opublikowane w: Nature Cell Biology, Numer 19/7, 2017, Strona(/y) 742-751, ISSN 1465-7392
Wydawca: Nature Publishing Group
DOI: 10.1038/ncb3564

Molecular clutch drives cell response to surface viscosity

Autorzy: Mark Bennett, Marco Cantini, Julien Reboud, Jonathan M. Cooper, Pere Roca-Cusachs, Manuel Salmeron-Sanchez
Opublikowane w: Proceedings of the National Academy of Sciences, Numer 115/6, 2018, Strona(/y) 1192-1197, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.1710653115

Sticking, steering, squeezing and shearing: cell movements driven by heterotypic mechanical forces

Autorzy: Anna Labernadie, Xavier Trepat
Opublikowane w: Current Opinion in Cell Biology, Numer 54, 2018, Strona(/y) 57-65, ISSN 0955-0674
Wydawca: Elsevier BV
DOI: 10.1016/j.ceb.2018.04.008

4D Biomaterials for Light‐Guided Angiogenesis

Autorzy: Aleeza Farrukh, Julieta I. Paez, Aránzazu del Campo
Opublikowane w: Advanced Functional Materials, Numer 29/6, 2019, Strona(/y) 1807734, ISSN 1616-301X
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201807734

Supracellular contraction at the rear of neural crest cell groups drives collective chemotaxis

Autorzy: Adam Shellard, András Szabó, Xavier Trepat, Roberto Mayor
Opublikowane w: Science, Numer 362/6412, 2018, Strona(/y) 339-343, ISSN 0036-8075
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/science.aau3301

Active superelasticity in three-dimensional epithelia of controlled shape

Autorzy: Ernest Latorre, Sohan Kale, Laura Casares, Manuel Gómez-González, Marina Uroz, Léo Valon, Roshna V. Nair, Elena Garreta, Nuria Montserrat, Aránzazu del Campo, Benoit Ladoux, Marino Arroyo, Xavier Trepat
Opublikowane w: Nature, Numer 563/7730, 2018, Strona(/y) 203-208, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41586-018-0671-4

Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells

Autorzy: Joseph Jose Thottacherry, Anita Joanna Kosmalska, Amit Kumar, Amit Singh Vishen, Alberto Elosegui-Artola, Susav Pradhan, Sumit Sharma, Parvinder P. Singh, Marta C. Guadamillas, Natasha Chaudhary, Ram Vishwakarma, Xavier Trepat, Miguel A. del Pozo, Robert G. Parton, Madan Rao, Pramod Pullarkat, Pere Roca-Cusachs, Satyajit Mayor
Opublikowane w: Nature Communications, Numer 9/1, 2018, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-018-06738-5

Forcing the reversibility of a mechanochemical reaction

Autorzy: Amy E. M. Beedle, Marc Mora, Colin T. Davis, Ambrosius P. Snijders, Guillaume Stirnemann, Sergi Garcia-Manyes
Opublikowane w: Nature Communications, Numer 9/1, 2018, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-018-05115-6

In Situ, Light-Guided Axon Growth on Biomaterials via Photoactivatable Laminin Peptidomimetic IK(HANBP)VAV

Autorzy: Aleeza Farrukh, Shifang Zhao, Julieta I. Paez, Atria Kavyanifar, Marcelo Salierno, Adolfo Cavalié, Aránzazu del Campo
Opublikowane w: ACS Applied Materials & Interfaces, Numer 10/48, 2018, Strona(/y) 41129-41137, ISSN 1944-8244
Wydawca: American Chemical Society
DOI: 10.1021/acsami.8b15517

A hybrid computational model for collective cell durotaxis

Autorzy: Jorge Escribano, Raimon Sunyer, María Teresa Sánchez, Xavier Trepat, Pere Roca-Cusachs, José Manuel García-Aznar
Opublikowane w: Biomechanics and Modeling in Mechanobiology, Numer 17/4, 2018, Strona(/y) 1037-1052, ISSN 1617-7959
Wydawca: Springer Verlag
DOI: 10.1007/s10237-018-1010-2

Loss of E-Cadherin-Dependent Cell–Cell Adhesion and the Development and Progression of Cancer

Autorzy: Heather C. Bruner, Patrick W.B. Derksen
Opublikowane w: Cold Spring Harbor Perspectives in Biology, Numer 10/3, 2018, Strona(/y) a029330, ISSN 1943-0264
Wydawca: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a029330

Re-inforcing the cell death army in the fight against breast cancer

Autorzy: Clara R. L. Oudenaarden, Robert A. H. van de Ven, Patrick W. B. Derksen
Opublikowane w: Journal of Cell Science, Numer 131/16, 2018, Strona(/y) jcs212563, ISSN 0021-9533
Wydawca: The Company of Biologists Ltd.
DOI: 10.1242/jcs.212563

Mesoscale physical principles of collective cell organization

Autorzy: Xavier Trepat, Erik Sahai
Opublikowane w: Nature Physics, Numer 14/7, 2018, Strona(/y) 671-682, ISSN 1745-2473
Wydawca: Nature Publishing Group
DOI: 10.1038/s41567-018-0194-9

DNA Binding Induces a Nanomechanical Switch in the RRM1 Domain of TDP-43

Autorzy: Yong Jian Wang, Palma Rico-Lastres, Ainhoa Lezamiz, Marc Mora, Carles Solsona, Guillaume Stirnemann, Sergi Garcia-Manyes
Opublikowane w: The Journal of Physical Chemistry Letters, Numer 9/14, 2018, Strona(/y) 3800-3807, ISSN 1948-7185
Wydawca: American Chemical Society
DOI: 10.1021/acs.jpclett.8b01494

A Photoactivatable α 5 β 1 -Specific Integrin Ligand

Autorzy: Roshna V. Nair, Aleeza Farrukh, Aránzazu del Campo
Opublikowane w: ChemBioChem, Numer 19/12, 2018, Strona(/y) 1280-1287, ISSN 1439-4227
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201800180

Control of Mechanotransduction by Molecular Clutch Dynamics

Autorzy: Alberto Elosegui-Artola, Xavier Trepat, Pere Roca-Cusachs
Opublikowane w: Trends in Cell Biology, Numer 28/5, 2018, Strona(/y) 356-367, ISSN 0962-8924
Wydawca: Elsevier BV
DOI: 10.1016/j.tcb.2018.01.008

Photoactivatable Adhesive Ligands for Light-Guided Neuronal Growth

Autorzy: Aleeza Farrukh, Wenqiang Fan, Shifang Zhao, Marcelo Salierno, Julieta I. Paez, Aránzazu del Campo
Opublikowane w: ChemBioChem, Numer 19/12, 2018, Strona(/y) 1271-1279, ISSN 1439-4227
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201800118

Regulation of cell cycle progression by cell–cell and cell–matrix forces

Autorzy: Marina Uroz, Sabrina Wistorf, Xavier Serra-Picamal, Vito Conte, Marta Sales-Pardo, Pere Roca-Cusachs, Roger Guimerà, Xavier Trepat
Opublikowane w: Nature Cell Biology, Numer 20/6, 2018, Strona(/y) 646-654, ISSN 1465-7392
Wydawca: Nature Publishing Group
DOI: 10.1038/s41556-018-0107-2

Mechanosensing at integrin-mediated cell–matrix adhesions: from molecular to integrated mechanisms

Autorzy: Nils C Gauthier, Pere Roca-Cusachs
Opublikowane w: Current Opinion in Cell Biology, Numer 50, 2018, Strona(/y) 20-26, ISSN 0955-0674
Wydawca: Elsevier BV
DOI: 10.1016/j.ceb.2017.12.014

TRPM7 controls mesenchymal features of breast cancer cells by tensional regulation of SOX4

Autorzy: Arthur J. Kuipers, Jeroen Middelbeek, Kirsten Vrenken, Carlos Pérez-González, Geert Poelmans, Jeffrey Klarenbeek, Kees Jalink, Xavier Trepat, Frank N. van Leeuwen
Opublikowane w: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Numer 1864/7, 2018, Strona(/y) 2409-2419, ISSN 0925-4439
Wydawca: Elsevier BV
DOI: 10.1016/j.bbadis.2018.04.017

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Autorzy: Essak S. Khan, Shrikrishnan Sankaran, Julieta I. Paez, Christina Muth, Mitchell K. L. Han, Aránzazu del Campo
Opublikowane w: Advanced Science, Numer 6/9, 2019, Strona(/y) 1801982, ISSN 2198-3844
Wydawca: WILEY-VCH Verlag GmbH & Co. KGaA
DOI: 10.1002/advs.201801982

Traction forces at the cytokinetic ring regulate cell division and polyploidy in the migrating zebrafish epicardium

Autorzy: Marina Uroz, Anna Garcia-Puig, Isil Tekeli, Alberto Elosegui-Artola, Juan F. Abenza, Ariadna Marín-Llauradó, Silvia Pujals, Vito Conte, Lorenzo Albertazzi, Pere Roca-Cusachs, Ángel Raya, Xavier Trepat
Opublikowane w: Nature Materials, 2019, ISSN 1476-1122
Wydawca: Nature Publishing Group
DOI: 10.1038/s41563-019-0381-9

The plasma membrane as a mechanochemical transducer

Autorzy: Anabel-Lise Le Roux, Xarxa Quiroga, Nikhil Walani, Marino Arroyo, Pere Roca-Cusachs
Opublikowane w: Philosophical Transactions of the Royal Society B: Biological Sciences, Numer 374/1779, 2019, Strona(/y) 20180221, ISSN 0962-8436
Wydawca: Royal Society of London
DOI: 10.1098/rstb.2018.0221

Patterning of human epidermal stem cells on undulating elastomer substrates reflects differences in cell stiffness

Autorzy: Seyedeh Atefeh Mobasseri, Sebastiaan Zijl, Vasiliki Salameti, Gernot Walko, Andrew Stannard, Sergi Garcia-Manyes, Fiona M. Watt
Opublikowane w: Acta Biomaterialia, Numer 87, 2019, Strona(/y) 256-264, ISSN 1742-7061
Wydawca: Elsevier BV
DOI: 10.1016/j.actbio.2019.01.063

The mechanical stability of proteins regulates their translocation rate into the cell nucleus

Autorzy: Elvira Infante, Andrew Stannard, Stephanie J. Board, Palma Rico-Lastres, Elena Rostkova, Amy E. M. Beedle, Ainhoa Lezamiz, Yong Jian Wang, Samuel Gulaidi Breen, Fani Panagaki, Vinoth Sundar Rajan, Catherine Shanahan, Pere Roca-Cusachs, Sergi Garcia-Manyes
Opublikowane w: Nature Physics, 2019, ISSN 1745-2473
Wydawca: Nature Publishing Group
DOI: 10.1038/s41567-019-0551-3

Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells

Autorzy: Elena Garreta, Patricia Prado, Carolina Tarantino, Roger Oria, Lucia Fanlo, Elisa Martí, Dobryna Zalvidea, Xavier Trepat, Pere Roca-Cusachs, Aleix Gavaldà-Navarro, Luca Cozzuto, Josep M. Campistol, Juan Carlos Izpisúa Belmonte, Carmen Hurtado del Pozo, Nuria Montserrat
Opublikowane w: Nature Materials, Numer 18/4, 2019, Strona(/y) 397-405, ISSN 1476-1122
Wydawca: Nature Publishing Group
DOI: 10.1038/s41563-019-0287-6

Integrins as biomechanical sensors of the microenvironment

Autorzy: Jenny Z. Kechagia, Johanna Ivaska, Pere Roca-Cusachs
Opublikowane w: Nature Reviews Molecular Cell Biology, Numer 20/8, 2019, Strona(/y) 457-473, ISSN 1471-0072
Wydawca: Nature Publishing Group
DOI: 10.1038/s41580-019-0134-2

Cadherin mechanotransduction in leader-follower cell specification during collective migration

Autorzy: Antoine A. Khalil, Johan de Rooij
Opublikowane w: Experimental Cell Research, Numer 376/1, 2019, Strona(/y) 86-91, ISSN 0014-4827
Wydawca: Academic Press
DOI: 10.1016/j.yexcr.2019.01.006

The Role of Mitotic Cell-Substrate Adhesion Re-modeling in Animal Cell Division

Autorzy: Christina L. Dix, Helen K. Matthews, Marina Uroz, Susannah McLaren, Lucie Wolf, Nicholas Heatley, Zaw Win, Pedro Almada, Ricardo Henriques, Michael Boutros, Xavier Trepat, Buzz Baum
Opublikowane w: Developmental Cell, Numer 45/1, 2018, Strona(/y) 132-145.e3, ISSN 1534-5807
Wydawca: Cell Press
DOI: 10.1016/j.devcel.2018.03.009

Gelation Kinetics and Mechanical Properties of Thiol‐Tetrazole Methylsulfone Hydrogels Designed for Cell Encapsulation

Autorzy: Adrián de Miguel-Jiménez, Bastian Ebeling, Julieta I. Paez, Claudia Fink-Straube, Samuel Pearson, Aránzazu del Campo
Opublikowane w: Macromolecular Bioscience, 2022, ISSN 1616-5195
Wydawca: Wiley-VCH Verlag
DOI: 10.1002/mabi.202200419

Elastomeric Optical Waveguides by Extrusion Printing

Autorzy: Jun Feng, Yijun Zheng, Qiyang Jiang, Małgorzata K. Włodarczyk-Biegun, Samuel Pearson, and Aránzazu del Campo
Opublikowane w: Advanced Materials Technologies, 2022, ISSN 2365-709X
Wydawca: Wiley-Blackwell
DOI: 10.1002/admt.202101539

Lighting the Path: Light Delivery Strategies to Activate Photoresponsive Biomaterials In Vivo

Autorzy: Samuel Pearson; Jun Feng; Jun Feng; Aránzazu del Campo; Aránzazu del Campo
Opublikowane w: Advanced Functional Materials, Numer 7, 2021, ISSN 1616-301X
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202105989

Embryonic self-fracking

Autorzy: Marino Arroyo, Xavier Trepat
Opublikowane w: Science, Numer 365/6452, 2019, Strona(/y) 442-443, ISSN 0036-8075
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/science.aay2860

Enhanced statistical sampling reveals microscopic complexity in the talin mechanosensor folding energy landscape

Autorzy: Tapia-Rojo, R; Mora, M; Board, S.J.; Walker, J; Boujemaa-Paterski, R.; Medalia, O; Garcia-Manyes, S.
Opublikowane w: Nature Physics, 2022, ISSN 1745-2473
Wydawca: Nature Publishing Group
DOI: 10.1038/s41567-022-01808-4

The role of single-protein elasticity in mechanobiology

Autorzy: Amy E. M. Beedle, Sergi Garcia-Manyes
Opublikowane w: Nature Review Materials, 2022, ISSN 2058-8437
Wydawca: Nature Publishing Group
DOI: 10.1038/s41578-022-00488-z

A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1

Autorzy: Donker L, Houtekamer R, Vliem M, Sipieter F, Canever H, Gómez-González M, Bosch-Padrós M, Pannekoek WJ, Trepat X, Borghi N, Gloerich M.
Opublikowane w: Cell Reports, 2022, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2022.111475

Protein nanomechanics: The power of stretching

Autorzy: Marc Mora, Sergi Garcia-Manyes
Opublikowane w: Europhysics News, Numer 51/5, 2020, Strona(/y) 24-27, ISSN 0531-7479
Wydawca: European Physical Society
DOI: 10.1051/epn/2020503

LGR6-dependent conditional inactivation of E-cadherin and p53 leads to invasive skin and mammary carcinomas in mice

Autorzy: Eline J. ter Steege; Thijmen Sijnesael; Lotte Enserink; Sjoerd Klarenbeek; Wisse E. Haakma; Elvira R.M. Bakker; Patrick W.B. Derksen
Opublikowane w: Neoplasia, 2022, ISSN 1522-8002
Wydawca: Elsevier BV
DOI: 10.1016/j.neo.2022.100844

Extracellular matrix anisotropy is determined by TFAP2C-dependent regulation of cell collisions

Autorzy: Danielle Park, Esther Wershof, Stefan Boeing, Anna Labernadie, Robert P. Jenkins, Samantha George, Xavier Trepat, Paul A. Bates, Erik Sahai
Opublikowane w: Nature Materials, Numer 19/2, 2020, Strona(/y) 227-238, ISSN 1476-1122
Wydawca: Nature Publishing Group
DOI: 10.1038/s41563-019-0504-3

A Single-Molecule Strategy to Capture Non-native Intramolecular and Intermolecular Protein Disulfide Bridges

Autorzy: Marc Mora, Stephanie Board, Olivier Languin-Cattoën, Laura Masino, Guillaume Stirnemann, Sergi Garcia-Manyes
Opublikowane w: Nano Letters, 2022, ISSN 1530-6984
Wydawca: American Chemical Society
DOI: 10.1021/acs.nanolett.2c00043

The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening

Autorzy: Ion Andreu, Bryan Falcones, Sebastian Hurst, Nimesh Chahare, Xarxa Quiroga, Anabel-Lise Le Roux, Zanetta Kechagia, Amy E. M. Beedle, Alberto Elosegui-Artola, Xavier Trepat, Ramon Farré, Timo Betz, Isaac Almendros & Pere Roca-Cusachs
Opublikowane w: Nature Communications, 2021, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-24383-3

Possibilities and Limitations of Photoactivatable Cytochalasin D for the Spatiotemporal Regulation of Actin Dynamics

Autorzy: Roshna V. Nair, Shifang Zhao, Emmanuel Terriac, Franziska Lautenschläger, Joseph H.R. Hetmanski, Patrick T. Caswell, Aranzazu del Campo
Opublikowane w: ChemRxiv, 2020, ISSN 2573-2293
Wydawca: ChemRxiv
DOI: 10.26434/chemrxiv.12609545.v1

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Numer wniosku/publikacji: 20 20067410
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Wnioskodawca/wnioskodawcy: LEIBNIZ-INSTITUT FUER NEUE MATERIALIEN GEMEINNUETZIGE GMBH

NOVEL HYDROGELS

Numer wniosku/publikacji: 20 20067410
Data: 2020-06-23
Wnioskodawca/wnioskodawcy: LEIBNIZ-INSTITUT FUER NEUE MATERIALIEN GEMEINNUETZIGE GMBH

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