Rezultaty Documents, reports (16) Network-based approaches to modulation of brain plasticity and micrographia in PD using non-invasive brain stimulation Networkbased approaches to modulation of brain plasticity and micrographia in PD using noninvasive brain stimulation In this part of the study we will include patients with PD and agematched healthy controls Results from taskinduced brain activation fMRI studies will be used and regions of betweengroups differences in brain activation changes in neural correlates of micrographia in PD patients will serve as our regions of interest ROIs for targeting an rTMS coil Using rTMS repetitive transcranial magnetic stimulation over two identified ROIs and over a control site ie over vertex we will evaluate whether rTMS may be an effective tool to modulate handwriting impairment in PD Progress report 1 The progress report will summarize the work done in the first year of the project including information on internal reports including report on subject recruitment and report on clinical and MRI data acquisition and analysisThe progress report will also include report on planned dissemination activities and public engamement conducted by the delivery date specifically one MSCA Open Days project website release information on the kickoff meeting information on a popular publication released M12 fMRI workshop organised at the MU and Course on Cognitive impairment and dementia Standardized protocol for language and acoustic assessment and analysis Standardized protocol for language and acoustic assessment and analysis We will design a short but as comprehensive as possible speech task that could be used in all 3 languages English Czech Hungarian and assess both dysarthria and apraxia of speech Specific acoustic analysis of speech data will be performed in all 3 languages The battery should not exceed 15 min of data acquisition We will test this in older healthy subjects MRI data acquisition for tasks 3, 4 MRI data acquisition for tasks 3 4 we will acquire data in healthy controls and patients with PD as described in the protocol and WP4 Structural MRI identified changes associated with impaired AMWM and abnormal brain activation/connectivity in PD Structural MRI identified changes associated with impaired AMWM and abnormal brain activationconnectivity in PD By structural MRI data analysis brain atrophy brain structural connectivity we will be able to identify structural correlates of deficits in attentional modulation of working memory in PD patients as compared to healthy controls Progress report II The second Progress report will present and summarize three years of the research project including reports on clinical and MRI data acquisition and analysis and on MRI data acquisition for tasks completed within the periodThe progress report will also include information on all dissemination activities to be completed by this report delivery month specifically two project consortium meeting two MSCA Open Days two participantion in European Researchers Night fMRI course and workshop organised at the MU and Neuroimaging Workshop on innovative methods organised at the USZ two runs of Course on Cognitive impairment and dementiaThis progreess report will also include plans for the remaing period of the project in the dissemination and public engagement activities which should include specifically one remianing MSCA Open Days in M41 one more popular magazine publication M48 one more participation in European Researchers Night M46 two International workshop on behavioural neurology organised at the MU and USZ M44 M48 one more fMRI course and workshop at the MU M40 one more Course on Cognitive impairment and dementia M46 and a workshop NIBS in modulation of brain plasticity and speech prosody handwriting in PD patients and healthy controls M40 M44 Standardized protocol for cognitive assessment and composite domain z-score calculation Standardized protocol for cognitive assessment and composite domain zscore calculation We will design a cognitive assessment battery that could be used in all 3 languages English Czech Hungarian Only tests validated in all 3 countries will be used to enable to calculate composite domain zscores in the following domains attention executive function memory visuospatial functions language The battery should not exceed 60 min of testing We will test feasibility of this battery in older healthy subjects Pilot data for kinematic assessment and analysis released Pilot data for kinematic assessment and analysis released We will develop a test a protocol for handwriting which would enables us to efficiently assess all aspects of micrographia dysgraphia in patients with Parkinsons disease PD We will use a digitizing tablet and assess both onsurface and inair movements We will use both healthy controls n10 and PD patients n10 for this pilot study Best handwriting parameters will be identified and described Pilot fMRI data for language and acoustic assessment Pilot fMRI data for language and acoustic assessment We will design and test an fMRI protocol an eventrelated fMRI taskinduced activation design to test reading of emotionally neutral short sentences in the scanner The speech data will be acquired and assessed for noise artefacts while performing the acoustic analysis of the speech data Pilot fMRI study will be performed in healthy controls and we will test and analyse fMRI data from 20 aged healthy subjects Kinematic abnormalities produced by damage to the cortical vs. subcortical components of the handwriting motor control network Kinematic abnormalities produced by damage to the cortical vs subcortical components of the handwriting motor control network Neural substrates of dysgraphia in patients with different neurological diseases across three different languages Patient groups and agematched healthy controls will be compared with respect to their brain structure changes In this part of the study we will evaluate lesion correlates of dysgraphia as described in the protocol and WP3 Patients with primary progressive aphasiaAlzheimers disease stroke patients and patients with Parkinsons disease will be included In PD patients and healthy controls we will additionally perform an fMRI study to assess functional correlates of impaired handwriting in PD and to identify the best cortical targets for an rTMS repetitive transcranial magnetic stimulation study see also below Specific behavioural and task-induced fMRI protocols for language and acoustic assessment Specific behavioural and taskinduced fMRI protocols for language and acoustic assessment Pilot fMRI protocols will be used to assess and compare neural correlates of speech prosody impairment in patients with Parkinsons disease and in agematched healthy controls Network-based approaches to modulation of brain plasticity and speech prosody in PD using non-invasive brain stimulation Networkbased approaches to modulation of brain plasticity and speech prosody in patients with Parkinsons disease PD using noninvasive brain stimulation In this part of the study we will include patients with PD and agematched healthy controls Results from taskinduced brain activation fMRI studies will be used and regions of betweengroups differences in brain activation changes in neural correlates of speech prosody in PD patients will serve as our regions of interest ROIs for targeting an rTMS coil Using rTMS repetitive transcranial magnetic stimulation over two identified ROIs and over a control site ie over vertex we will evaluate whether rTMS may be an effective tool to modulate speech prosody in PD We will identify ROI with the best behavioural stimulation aftereffects and then we will use multiplesession rTMS with an aim to treat speech prosody impairment in PD Neural substrates of speech prosody impairment in patients with different neurological diseases across three different languages Neural substrates of speech prosody impairment in patients with different neurological diseases across three different languages Patient groups and agematched healthy controls will be compared with respect to their brain structure changes In this part of the study we will evaluate lesion correlates of dysarthria and apraxia of speech as described in the protocol and WP2 Patients with primary progressive aphasiaAlzheimers disease stroke patients and patients with Parkinsons disease will be included Identification of alterations in patterns of brain activation and connectivity associated with deficient AMWM in PD using fMRI Identification of alterations in patterns of brain activation and connectivity associated with deficient AMWM in PD using fMRI By functional MRI data analysis we will be able to identify functional correlates of deficits in attentional modulation of working memory in PD patients as compared to healthy controls We will specifically study deficits in bottomup and topdown control of attentional visual processing Behavioural deficits in the attentional modulation of working memory (AMWM) in patients with Parkinson's disease (PD) Behavioural deficits in the attentional modulation of working memory AMWM in patients with Parkinsons disease PD Using data from the MRI scanner we will be able to evaluate behavioural deficits in the attentional modulation of working memory AMWM in patients with PD as compared to healthy controls Pilot MRI data We will design and test two fMRI protocols eventrelated fMRI taskinduced activation designs to test attentional modulation of working memory using a visual task as described in the protocol and WP4 Pilot fMRI study will be performed in healthy controls and we will test and analyse fMRI data from 10 young healthy subjects for each of the fMRI task Other (2) Publication of novel parametrization software for kinematic analysis Publication of novel parametrization software for kinematic analysis Since hundreds of parameters may be analysed by using kinematic analysis of handwriting data and it is very timeconsuming we will develop a novel parametrization software to speed the whole process and we will identify and choose only those kinematic parameters that best reflect micrographia dysgraphia Novel parametrization software for acoustic analysis Novel parametrization software for acoustic analysis Since hundreds of parameters may be analysed by using acoustic analysis of speech data and it is very timeconsuming we will develop a novel parametrization software to speed the whole process and we will identify and choose only those speech parameters that reflect both dysarthria and apraxia of speech in the most efficient way Websites, patent fillings, videos etc. (1) Project website A project website will be released presenting the project and its results to general and expert publicIt will present the institutions involved and the ey researchers It will also be a place where there will be presented results of the research and its progress as well as training and other academic activities of the partners Publikacje Peer reviewed articles (18) Non-invasive brain stimulation for speech in Parkinson’s disease: A randomized controlled trial Autorzy: BRABENEC, L.; KLOBUŠIAKOVÁ, P.; ŠIMKO, P.; KOŠŤÁLOVÁ, M.; MEKYSKA, J.; REKTOROVÁ, I. Opublikowane w: BRAIN STIMULATION, 2021, ISSN 1935-861X Wydawca: Elsevier BV DOI: 10.1016/j.brs.2021.03.010 Altered brain network function during attention-modulated visual processing in multiple sclerosis Autorzy: Dániel Veréb, Eszter Tóth, Bence Bozsik, András Király, Nikoletta Szabó, Bálint Kincses, Krisztián Kocsis, Péter Faragó, Vécsei László, Krisztina Bencsik, Péter Klivényi, Zsigmond Tamás Kincses Opublikowane w: Multiple Sclerosis Journal, 2020, Page(s) 135245852095836, ISSN 1352-4585 Wydawca: SAGE Publications DOI: 10.1177/1352458520958360 Evidence for Plastic Processes in Migraine with Aura: A Diffusion Weighted MRI Study Autorzy: Nikoletta Szabó, Péter Faragó, András Király, Dániel Veréb, Gergő Csete, Eszter Tóth, Krisztián Kocsis, Bálint Kincses, Bernadett Tuka, Árpád Párdutz, Délia Szok, János Tajti, László Vécsei, Zsigmond T. Kincses Opublikowane w: Frontiers in Neuroanatomy, Issue 11, 2018, ISSN 1662-5129 Wydawca: Frontiers Research Foundation DOI: 10.3389/fnana.2017.00138 Temporal instability of salience network activity in migraine with aura Autorzy: Veréb, D., Szabó, N., Tuka, B., Tajti, J., Király, A., Faragó, P., … Kincses, Z. T. Opublikowane w: PAIN, 2020, ISSN 0304-3959 Wydawca: Elsevier BV DOI: 10.1097/j.pain.0000000000001770 Articulatory network reorganization in Parkinson's disease as assessed by multimodal MRI and acoustic measures Autorzy: Patricia Klobusiakova, Jiri Mekyska, Lubos Brabenec, Zoltan Galaz, Vojtech Zvoncak, Jan Mucha, Steven Z. Rapcsak, Irena Rektorova Opublikowane w: Parkinsonism & Related Disorders, Issue 84, 2021, Page(s) 122-128, ISSN 1353-8020 Wydawca: Elsevier BV DOI: 10.1016/j.parkreldis.2021.02.012 Lateralisation of the white matter microstructure associated with the hemispheric spatial attention dominance Autorzy: Krisztián Kocsis, Gergő Csete, Zsombor Erdei, András Király, Nikoletta Szabó, László Vécsei, Zsigmond Tamás Kincses Opublikowane w: PLOS ONE, Issue 14/4, 2019, Page(s) e0216032, ISSN 1932-6203 Wydawca: Public Library of Science DOI: 10.1371/journal.pone.0216032 Shannon entropy: A novel parameter for quantifying pentagon copying performance in non-demented Parkinson's disease patients Autorzy: Lubos Brabenec, Patricia Klobusiakova, Jiri Mekyska, Irena Rektorova Opublikowane w: PARKINSONISM & RELATED DISORDERS, 2022, ISSN 1353-8020 Wydawca: Elsevier BV DOI: 10.1016/j.parkreldis.2021.11.037 Are Migraine With and Without Aura Really Different Entities? Autorzy: Zsigmond Tamás Kincses, Dániel Veréb, Péter Faragó, Eszter Tóth, Krisztián Kocsis, Bálint Kincses, András Király, Bence Bozsik, Árpád Párdutz, Délia Szok, János Tajti, László Vécsei, Bernadett Tuka, Nikoletta Szabó Opublikowane w: Frontiers in Neurology, Issue 10, 2019, ISSN 1664-2295 Wydawca: Frontiers Research Foundation DOI: 10.3389/fneur.2019.00982 Patterns of diffusion kurtosis changes in Parkinson's disease subtypes Autorzy: Alzbeta Sejnoha Minsterova, Patricia Klobusiakova, Adrian Pies, Zoltan Galaz, Jiri Mekyska, Lubomira Novakova, Nela Nemcova Elfmarkova, Irena Rektorova Opublikowane w: Parkinsonism & Related Disorders, Issue 81, 2020, Page(s) 96-102, ISSN 1353-8020 Wydawca: Elsevier BV DOI: 10.1016/j.parkreldis.2020.10.032 Gray Matter Changes in Parkinson’s and Alzheimer’s Disease and Relation to Cognition Autorzy: Lenka Krajcovicova, Patricia Klobusiakova, Irena Rektorova Opublikowane w: Current Neurology and Neuroscience Reports, Issue 19/11, 2019, ISSN 1528-4042 Wydawca: Current Science Inc. DOI: 10.1007/s11910-019-1006-z Altered Resting State Functional Activity and Microstructure of the White Matter in Migraine With Aura Autorzy: Péter Faragó, Eszter Tóth, Krisztián Kocsis, Bálint Kincses, Dániel Veréb, András Király, Bence Bozsik, János Tajti, Árpád Párdutz, Délia Szok, László Vécsei, Nikoletta Szabó, Zsigmond Tamás Kincses Opublikowane w: Frontiers in Neurology, Issue 10, 2019, ISSN 1664-2295 Wydawca: Frontiers Research Foundation DOI: 10.3389/fneur.2019.01039 Two Classes of T1 Hypointense Lesions in Multiple Sclerosis With Different Clinical Relevance Autorzy: Krisztián Kocsis, Nikoletta Szabó, Eszter Tóth, András Király, Péter Faragó, Bálint Kincses, Dániel Veréb, Bence Bozsik, Katalin Boross, Melinda Katona, Péter Bodnár, Nyúl Gábor László, László Vécsei, Péter Klivényi, Krisztina Bencsik, Zsigmond Tamás Kincses Opublikowane w: Frontiers in Neurology, Issue 12, 2021, ISSN 1664-2295 Wydawca: Frontiers Research Foundation DOI: 10.3389/fneur.2021.619135 Neural evidence for defective top-down control of visual processing in Parkinson's and Alzheimer's disease Autorzy: Nela Nemcova Elfmarkova, Martin Gajdos, Irena Rektorova, Radek Marecek, Steven Z. Rapcsak Opublikowane w: Neuropsychologia, Issue 106, 2017, Page(s) 236-244, ISSN 0028-3932 Wydawca: Pergamon Press Ltd. DOI: 10.1016/j.neuropsychologia.2017.09.034 Identification and Monitoring of Parkinson’s Disease Dysgraphia Based on Fractional-Order Derivatives of Online Handwriting Autorzy: Jan Mucha, Jiri Mekyska, Zoltan Galaz, Marcos Faundez-Zanuy, Karmele Lopez-de-Ipina, Vojtech Zvoncak, Tomas Kiska, Zdenek Smekal, Lubos Brabenec, Irena Rektorova Opublikowane w: Applied Sciences, Issue 8/12, 2018, Page(s) 2566, ISSN 2076-3417 Wydawca: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/app8122566 Non-invasive stimulation of the auditory feedback area for improved articulation in Parkinson's disease Autorzy: Lubos Brabenec, Patricia Klobusiakova, Marek Barton, Jiri Mekyska, Zoltan Galaz, Vojtech Zvoncak, Tomas Kiska, Jan Mucha, Zdenek Smekal, Milena Kostalova, Irena Rektorova Opublikowane w: Parkinsonism & Related Disorders, 2018, ISSN 1353-8020 Wydawca: Elsevier BV DOI: 10.1016/j.parkreldis.2018.10.011 Direct effects of transcranial electric stimulation on brain circuits in rats and humans Autorzy: Mihály Vöröslakos, Yuichi Takeuchi, Kitti Brinyiczki, Tamás Zombori, Azahara Oliva, Antonio Fernández-Ruiz, Gábor Kozák, Zsigmond Tamás Kincses, Béla Iványi, György Buzsáki, Antal Berényi Opublikowane w: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723 Wydawca: Nature Publishing Group DOI: 10.1038/s41467-018-02928-3 Brain MRI Diffusion Encoding Direction Number Affects Tract‐Based Spatial Statistics Results in Multiple Sclerosis Autorzy: Bálint Kincses, Tamás Spisák, Péter Faragó, András Király, Nikoletta Szabó, Dániel Veréb, Krisztián Kocsis, Bence Bozsik, Eszter Tóth, László Vécsei, Zsigmond Tamás Kincses Opublikowane w: Journal of Neuroimaging, Issue 30/4, 2020, Page(s) 512-522, ISSN 1051-2284 Wydawca: Sage Science Press DOI: 10.1111/jon.12705 Current treatment of behavioral and cognitive symptoms of Parkinson's disease Autorzy: Irena Rektorova Opublikowane w: Parkinsonism & Related Disorders, Issue 59, 2019, Page(s) 65-73, ISSN 1353-8020 Wydawca: Elsevier BV DOI: 10.1016/j.parkreldis.2019.02.042 Conference proceedings (1) Multilingual Analysis of Speech and Voice Disorders in Patients with Parkinson’s Disease Autorzy: Daniel Kovac, Jiri Mekyska, Zoltan Galaz, Lubos Brabenec, Milena Kostalova, Steven Z. Rapcsak, Irena Rektorova Opublikowane w: 2021 44th International Conference on Telecommunications and Signal Processing (TSP), 2021, Page(s) 273-277, ISBN 978-1-6654-2933-7 Wydawca: IEEE DOI: 10.1109/tsp52935.2021.9522597 Wyszukiwanie danych OpenAIRE... Podczas wyszukiwania danych OpenAIRE wystąpił błąd Brak wyników
