Targeting IRE1 in disease

Risultati finali

Consortium web site established
Creation of Facebook & Twitter accounts

Pubblicazioni

Tumour Cell Secretome in Chemoresistance and Tumour Recurrence

Autori: Emma C. Madden, Adrienne M. Gorman, Susan E. Logue, Afshin Samali
Pubblicato in: Trends in Cancer, Numero 6/6, 2020, Pagina/e 489-505, ISSN 2405-8033
Editore: Cell Press
DOI: 10.1016/j.trecan.2020.02.020

Pharmacological Targeting of IRE1 in Cancer

Autori: Diana Pelizzari Raymundo, Dimitrios Doultsinos, Xavier Guillory, Antonio Carlesso, Leif A. Eriksson, Eric Chevet
Pubblicato in: Trends in Cancer, Numero 6/12, 2020, Pagina/e 1018-1030, ISSN 2405-8033
Editore: Cell Press
DOI: 10.1016/j.trecan.2020.07.006

The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors

Autori: Mohamed Mahameed, Thomas Wilhelm, Odai Darawshi, Akram Obiedat, Weiss-Sadan Tommy, Chetan Chintha, Thomas Schubert, Afshin Samali, Eric Chevet, Leif A. Eriksson, Michael Huber, Boaz Tirosh
Pubblicato in: Cell Death & Disease, Numero 10/4, 2019, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-019-1523-3

Regulation of lipid metabolism by the unfolded protein response

Autori: Matthieu Moncan, Katarzyna Mnich, Arnaud Blomme, Aitor Almanza, Afshin Samali, Adrienne M. Gorman
Pubblicato in: Journal of Cellular and Molecular Medicine, Numero 25/3, 2021, Pagina/e 1359-1370, ISSN 1582-1838
Editore: Wiley-Blackwell
DOI: 10.1111/jcmm.16255

New insights on human IRE1 tetramer structures based on molecular modeling

Autori: Antonio Carlesso, Johanna Hörberg, Anna Reymer, Leif A. Eriksson
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-74347-8

When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response

Autori: Matías González-Quiroz, Alice Blondel, Alfredo Sagredo, Claudio Hetz, Eric Chevet, Rémy Pedeux
Pubblicato in: Trends in Cell Biology, Numero 30/11, 2020, Pagina/e 881-891, ISSN 0962-8924
Editore: Elsevier BV
DOI: 10.1016/j.tcb.2020.09.002

Deciphering the selectivity of inhibitor MKC9989 towards residue K907 in IRE1α; a multiscale in silico approach

Autori: Sayyed Jalil Mahdizadeh, Antonio Carlesso, Leif A. Eriksson
Pubblicato in: RSC Advances, Numero 10/33, 2020, Pagina/e 19720-19729, ISSN 2046-2069
Editore: Royal Society of Chemistry
DOI: 10.1039/d0ra01895c

Reconstruction of the Fas-Based Death-Inducing Signaling Complex (DISC) Using a Protein–Protein Docking Meta-Approach

Autori: Sayyed Jalil Mahdizadeh, Melissa Thomas, Leif A. Eriksson
Pubblicato in: Journal of Chemical Information and Modeling, Numero 61/7, 2021, Pagina/e 3543-3558, ISSN 1549-9596
Editore: American Chemical Society
DOI: 10.1021/acs.jcim.1c00301

Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease

Autori: Cynthia Lebeaupin, Deborah Vallée, Younis Hazari, Claudio Hetz, Eric Chevet, Béatrice Bailly-Maitre
Pubblicato in: Journal of Hepatology, Numero 69/4, 2018, Pagina/e 927-947, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2018.06.008

Control of anterior GR adient 2 ( AGR 2) dimerization links endoplasmic reticulum proteostasis to inflammation

Autori: Marion Maurel, Joanna Obacz, Tony Avril, Yong‐Ping Ding, Olga Papadodima, Xavier Treton, Fanny Daniel, Eleftherios Pilalis, Johanna Hörberg, Wenyang Hou, Marie‐Claude Beauchamp, Julien Tourneur‐Marsille, Dominique Cazals‐Hatem, Lucia Sommerova, Afshin Samali, Jan Tavernier, Roman Hrstka, Aurélien Dupont, Delphine Fessart, Frédéric Delom, Martin E Fernandez‐Zapico, Gregor Jansen, Leif
Pubblicato in: EMBO Molecular Medicine, Numero 11/6, 2019, ISSN 1757-4676
Editore: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201810120

Control of Protein Homeostasis in the Early Secretory Pathway: Current Status and Challenges

Autori: Daria Sicari, Aeid Igbaria, Eric Chevet
Pubblicato in: Cells, Numero 8/11, 2019, Pagina/e 1347, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells8111347

Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics

Autori: Amado Carreras-Sureda, Fabián Jaña, Hery Urra, Sylvere Durand, David E. Mortenson, Alfredo Sagredo, Galdo Bustos, Younis Hazari, Eva Ramos-Fernández, Maria L. Sassano, Philippe Pihán, Alexander R. van Vliet, Matías González-Quiroz, Angie K. Torres, Cheril Tapia-Rojas, Martijn Kerkhofs, Rubén Vicente, Randal J. Kaufman, Nibaldo C. Inestrosa, Christian Gonzalez-Billault, R. Luke Wiseman, Patr
Pubblicato in: Nature Cell Biology, Numero 21/6, 2019, Pagina/e 755-767, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/s41556-019-0329-y

Peptidomimetic‐based identification of FDA‐approved compounds inhibiting IRE1 activity

Autori: Dimitrios Doultsinos, Antonio Carlesso, Chetan Chintha, James C. Paton, Adrienne W. Paton, Afshin Samali, Eric Chevet, Leif A. Eriksson
Pubblicato in: The FEBS Journal, Numero 288/3, 2021, Pagina/e 945-960, ISSN 1742-464X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/febs.15372

The UPRosome – decoding novel biological outputs of IRE1α function

Autori: Hery Urra, Philippe Pihán, Claudio Hetz
Pubblicato in: Journal of Cell Science, Numero 133/15, 2020, ISSN 0021-9533
Editore: The Company of Biologists Ltd.
DOI: 10.1242/jcs.218107

The p75NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability

Autori: Viviana Pérez, Francisca Bermedo-Garcia, Diego Zelada, Felipe A. Court, Miguel Ángel Pérez, Marco Fuenzalida, Johanna Ábrigo, Claudio Cabello-Verrugio, Guillermo Moya-Alvarado, Juan Carlos Tapia, Vicente Valenzuela, Claudio Hetz, Francisca C. Bronfman, Juan Pablo Henríquez
Pubblicato in: Acta Neuropathologica Communications, Numero 7/1, 2019, ISSN 2051-5960
Editore: BioMed Central
DOI: 10.1186/s40478-019-0802-7

Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α

Autori: Denisse Sepulveda, Diego Rojas-Rivera, Diego A. Rodríguez, Jody Groenendyk, Andres Köhler, Cynthia Lebeaupin, Shinya Ito, Hery Urra, Amado Carreras-Sureda, Younis Hazari, Mireille Vasseur-Cognet, Maruf M.U. Ali, Eric Chevet, Gisela Campos, Patricio Godoy, Tomas Vaisar, Béatrice Bailly-Maitre, Kazuhiro Nagata, Marek Michalak, Jimena Sierralta, Claudio Hetz
Pubblicato in: Molecular Cell, Numero 69/2, 2018, Pagina/e 238-252.e7, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2017.12.028

Dual IRE1 RNase functions dictate glioblastoma development

Autori: Stéphanie Lhomond, Tony Avril, Nicolas Dejeans, Konstantinos Voutetakis, Dimitrios Doultsinos, Mari McMahon, Raphaël Pineau, Joanna Obacz, Olga Papadodima, Florence Jouan, Heloise Bourien, Marianthi Logotheti, Gwénaële Jégou, Néstor Pallares‐Lupon, Kathleen Schmit, Pierre‐Jean Le Reste, Amandine Etcheverry, Jean Mosser, Kim Barroso, Elodie Vauléon, Marion Maurel, Afshin Samali, John B P
Pubblicato in: EMBO Molecular Medicine, Numero 10/3, 2018, Pagina/e e7929, ISSN 1757-4676
Editore: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201707929

Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy

Autori: Susan E. Logue, Eoghan P. McGrath, Patricia Cleary, Stephanie Greene, Katarzyna Mnich, Aitor Almanza, Eric Chevet, Róisín M. Dwyer, Anup Oommen, Patrick Legembre, Florence Godey, Emma C. Madden, Brian Leuzzi, Joanna Obacz, Qingping Zeng, John B. Patterson, Richard Jäger, Adrienne M. Gorman, Afshin Samali
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-05763-8

Regulation of tumor-stroma interactions by the unfolded protein response

Autori: Joanna Obacz, Tony Avril, Camila Rubio-Patiño, Jozef P. Bossowski, Aeid Igbaria, Jean-Ehrland Ricci, Eric Chevet
Pubblicato in: The FEBS Journal, 2017, ISSN 1742-464X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/febs.14359

The Unfolded Protein Response: At the Intersection between Endoplasmic Reticulum Function and Mitochondrial Bioenergetics

Autori: Amado Carreras-Sureda, Philippe Pihán, Claudio Hetz
Pubblicato in: Frontiers in Oncology, Numero 7, 2017, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2017.00055

Fine-Tuning ER Stress Signal Transducers to Treat Amyotrophic Lateral Sclerosis

Autori: Danilo B. Medinas, Jose V. González, Paulina Falcon, Claudio Hetz
Pubblicato in: Frontiers in Molecular Neuroscience, Numero 10, 2017, ISSN 1662-5099
Editore: Frontiers Research Foundation
DOI: 10.3389/fnmol.2017.00216

Drug repurposing to target proteostasis and prevent neurodegeneration: accelerating translational efforts

Autori: Gabriela Mercado, Claudio Hetz
Pubblicato in: Brain, Numero 140/6, 2017, Pagina/e 1544-1547, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awx107

Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications

Autori: Aitor Almanza, Antonio Carlesso, Chetan Chintha, Stuart Creedican, Dimitrios Doultsinos, Brian Leuzzi, Andreia Luís, Nicole McCarthy, Luigi Montibeller, Sanket More, Alexandra Papaioannou, Franziska Püschel, Maria Livia Sassano, Josip Skoko, Patrizia Agostinis, Jackie de Belleroche, Leif A. Eriksson, Simone Fulda, Adrienne M. Gorman, Sandra Healy, Andrey Kozlov, Cristina Muñoz-Pinedo, Markus Re
Pubblicato in: The FEBS Journal, Numero 286/2, 2019, Pagina/e 241-278, ISSN 1742-464X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/febs.14608

The Unfolded Protein Response and Cell Fate Control

Autori: Claudio Hetz, Feroz R. Papa
Pubblicato in: Molecular Cell, Numero 69/2, 2018, Pagina/e 169-181, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2017.06.017

BCL-2 family: integrating stress responses at the ER to control cell demise

Autori: Philippe Pihán, Amado Carreras-Sureda, Claudio Hetz
Pubblicato in: Cell Death and Differentiation, Numero 24/9, 2017, Pagina/e 1478-1487, ISSN 1350-9047
Editore: Nature Publishing Group
DOI: 10.1038/cdd.2017.82

Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43A315T ALS/FTD mouse model

Autori: Leslie Bargsted, Danilo B. Medinas, Francisca Martínez Traub, Pablo Rozas, Natalia Muñoz, Melissa Nassif, Carolina Jerez, Alejandra Catenaccio, Felipe A. Court, Claudio Hetz, Soledad Matus
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-017-14399-5

The Unfolded Protein Response in Breast Cancer

Autori: Eoghan McGrath, Susan Logue, Katarzyna Mnich, Shane Deegan, Richard Jäger, Adrienne Gorman, Afshin Samali
Pubblicato in: Cancers, Numero 10/10, 2018, Pagina/e 344, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers10100344

IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A

Autori: Hery Urra, Daniel R. Henriquez, José Cánovas, David Villarroel-Campos, Amado Carreras-Sureda, Eduardo Pulgar, Emiliano Molina, Younis M. Hazari, Celia M. Limia, Sebastián Alvarez-Rojas, Ricardo Figueroa, Rene L. Vidal, Diego A. Rodriguez, Claudia A. Rivera, Felipe A. Court, Andrés Couve, Ling Qi, Eric Chevet, Ryoko Akai, Takao Iwawaki, Miguel L. Concha, Álvaro Glavic, Christian Gonzalez-Billa
Pubblicato in: Nature Cell Biology, Numero 20/8, 2018, Pagina/e 942-953, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/s41556-018-0141-0

A guide to assessing endoplasmic reticulum homeostasis and stress in mammalian systems

Autori: Daria Sicari, Agnès Delaunay‐Moisan, Laurent Combettes, Eric Chevet, Aeid Igbaria
Pubblicato in: The FEBS Journal, Numero 287/1, 2019, Pagina/e 27-42, ISSN 1742-464X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/febs.15107

The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease

Autori: Maritza Oñate, Alejandra Catenaccio, Natalia Salvadores, Cristian Saquel, Alexis Martinez, Ines Moreno-Gonzalez, Nazaret Gamez, Paulina Soto, Claudio Soto, Claudio Hetz, Felipe A. Court
Pubblicato in: Cell Death & Differentiation, Numero 27/4, 2020, Pagina/e 1169-1185, ISSN 1350-9047
Editore: Nature Publishing Group
DOI: 10.1038/s41418-019-0408-4

Molecular modeling provides a structural basis for PERK inhibitor selectivity towards RIPK1

Autori: Chetan Chintha, Antonio Carlesso, Adrienne M. Gorman, Afshin Samali, Leif A. Eriksson
Pubblicato in: RSC Advances, Numero 10/1, 2020, Pagina/e 367-375, ISSN 2046-2069
Editore: Royal Society of Chemistry
DOI: 10.1039/c9ra08047c

CD90/Thy-1, a Cancer-Associated Cell Surface Signaling Molecule

Autori: Chloé Sauzay, Konstantinos Voutetakis, Aristotelis Chatziioannou, Eric Chevet, Tony Avril
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 7, 2019, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2019.00066

Role of the early secretory pathway in SARS-CoV-2 infection

Autori: Daria Sicari, Aristotelis Chatziioannou, Theodoros Koutsandreas, Roberto Sitia, Eric Chevet
Pubblicato in: Journal of Cell Biology, Numero 219/9, 2020, ISSN 0021-9525
Editore: Rockefeller University Press
DOI: 10.1083/jcb.202006005

Emerging Roles of the Endoplasmic Reticulum Associated Unfolded Protein Response in Cancer Cell Migration and Invasion

Autori: Celia Limia, Chloé Sauzay, Hery Urra, Claudio Hetz, Eric Chevet, Tony Avril
Pubblicato in: Cancers, Numero 11/5, 2019, Pagina/e 631, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11050631

Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response

Autori: Estefanie Dufey, José Manuel Bravo-San Pedro, Cristian Eggers, Matías González-Quiroz, Hery Urra, Alfredo I. Sagredo, Denisse Sepulveda, Philippe Pihán, Amado Carreras-Sureda, Younis Hazari, Eduardo A. Sagredo, Daniela Gutierrez, Cristian Valls, Alexandra Papaioannou, Diego Acosta-Alvear, Gisela Campos, Pedro M. Domingos, Rémy Pedeux, Eric Chevet, Alejandra Alvarez, Patricio Godoy, Peter Walt
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-15694-y

Risultati finali

Pubblicazioni

Condividi questa pagina

Scarica