Towards Early Molecular Diagnostics of Schizophrenia

Risultati finali

Dissemination and communication plan

Dissemination and communication plan, responsible partner: PB, M5

SZ_TEST events

Project events taking place in months 12 24 36 66

Promotional materials including a dedicated website

Promotional materials including a dedicated website, responsible partner: PB, M6

Pubblicazioni

The Unfolded Protein Response and Autophagy as Drug Targets in Neuropsychiatric Disorders.

Autori: Srinivasan V, Korhonen L, Lindholm D.
Pubblicato in: Front Cell Neurosci., 2020, ISSN 1662-5099
Editore: Frontiers Research Foundation
DOI: 10.3389/fncel.2020.554548

Sphingolipids as Modulators of SARS-CoV-2 Infection.

Autori: Törnquist K, Asghar MY, Srinivasan V, Korhonen L, Lindholm D.
Pubblicato in: Front Cell Dev, 2021, ISSN 2296-634X
Editore: Frontiers Media S.A
DOI: 10.3389/fcell.2021.689854

Daughterless, the Drosophila orthologue of TCF4, is required for associative learning and maintenance of the synaptic proteome

Autori: Tamberg, Laura; Jaago, Mariliis; Säälik, Kristi; Shubina, Anastassia; Kiir, Carl Sander; Sirp, Alex; Timmusk, Tõnis; Palgi, Mari
Pubblicato in: Disease Models & Mechanisms, 2020, ISSN 1754-8403
Editore: The Company of Biologists Ltd.
DOI: 10.1242/dmm.042747

The Fuchs corneal dystrophy-associated CTG repeat expansion in the TCF4 gene affects transcription from its alternative promoters

Autori: Alex Sirp, Kristian Leite, Jürgen Tuvikene, Kaja Nurm, Mari Sepp & Tõnis Timmusk
Pubblicato in: Scientific Reports, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-75437-3

PGC-1α Signaling Increases GABA(A) Receptor Subunit α2 Expression, GABAergic Neurotransmission and Anxiety-Like Behavior in Mice.

Autori: Vanaveski T, Molchanova S, Pham DD, Schäfer A, Pajanoja C, Narvik J, Srinivasan V, Urb M, Koivisto M, Vasar E, Timmusk T, Minkeviciene R, Eriksson O, Lalowski M, Taira T, Korhonen L, Voikar V, Lindholm D
Pubblicato in: Front Mol Neurosci., 2021, ISSN 1662-5099
Editore: Frontiers Research Foundation
DOI: 10.3389/fnmol.2021.588230

Antibody response to oral biofilm is a biomarker for acute coronary syndrome in periodontal disease

Autori: Jaago M, Pupina N, Rähni A, Pihlak A, Sadam H, Vrana NE, Sinisalo J, Pussinen P, Palm K
Pubblicato in: Commun Biol., 2022, ISSN 2399-3642
Editore: Nature Portfolio
DOI: 10.1038/s42003-022-03122-4

Functional Annotation of Custom Transcriptomes.

Autori: Hamid, F., Alasoo, K., Vilo, J., Makeyev, E
Pubblicato in: Methods in Molecular Biology, 2022, ISSN 1064-3745
Editore: Humana Press, Inc.
DOI: 10.1007/978-1-0716-2521-7_9

Intronic enhancer region governs transcript-specific Bdnf expression in rodent neurons

Autori: Jürgen Tuvikene Eli-Eelika Esvald Annika Rähni Kaie Uustalu Anna Zhuravskaya Annela Avarlaid Eugene V Makeyev Tõnis Timmusk
Pubblicato in: eLife, 2021, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.65161

A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons

Autori: Patricia M. Gordon, Fursham Hamid, Eugene V. Makeyev & Corinne Houart
Pubblicato in: Nature Communications, Numero 12, 2021, Pagina/e 1918, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-22098-z

Hybridization-proximity labeling reveals spatially ordered interactions of nuclear RNA compartments

Autori: Karen Yap; Tek Hong Chung;Eugene V. Makeyev;
Pubblicato in: Molecular Cell, 2022, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2021.10.009

Functional consequences of TCF4 missense substitutions associated with Pitt-Hopkins syndrome, mild intellectual disability, and schizophrenia

Autori: Alex Sirp, Kaisa Roots, Kaja Nurm, Jürgen Tuvikene, Mari Sepp and Tõnis Timmusk
Pubblicato in: Journal of Biological Chemistry, Numero 297, 2021, Pagina/e 101381, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.101381

Immune response to a conserved enteroviral epitope of the major capsid VP1 protein is associated with lower risk of cardiovascular disease.

Autori: Pupina N, Avarlaid A, Sadam H, Pihlak A, Jaago M, Tuvikene J, Rähni A, Planken A, Planken M, Kalso E, Tienari PJ, Nieminen JK, Seppänen MRJ, Vaheri A, Lindholm D, Sinisalo J, Pussinen P, Timmusk T, Palm K.
Pubblicato in: EBioMedicine, Numero 23523964, 2022, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2022.103835

A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells

Autori: Yaroslav A. Kainov, Eugene V. Makeyev
Pubblicato in: Nature Communications, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-14204-z

The Intellectual Disability and Schizophrenia Associated Transcription Factor TCF4 Is Regulated by Neuronal Activity and Protein Kinase A

Autori: Mari Sepp, Hanna Vihma, Kaja Nurm, Mari Urb, Stephanie Cerceo Page, Kaisa Roots, Anu Hark, Brady J. Maher, Priit Pruunsild, Tõnis Timmusk
Pubblicato in: The Journal of Neuroscience, Numero 37/43, 2017, Pagina/e 10516-10527, ISSN 0270-6474
Editore: Society for Neuroscience
DOI: 10.1523/JNEUROSCI.1151-17.2017

Mutant Muscle LIM Protein C58G causes cardiomyopathy through protein depletion

Autori: Mehroz Ehsan, Matthew Kelly, Charlotte Hooper, Arash Yavari, Julia Beglov, Mohamed Bellahcene, Kirandeep Ghataorhe, Giulia Poloni, Anuj Goel, Theodosios Kyriakou, Karin Fleischanderl, Elisabeth Ehler, Eugene Makeyev, Stephan Lange, Houman Ashrafian, Charles Redwood, Benjamin Davies, Hugh Watkins, Katja Gehmlich
Pubblicato in: Journal of Molecular and Cellular Cardiology, Numero 121, 2018, Pagina/e 287-296, ISSN 0022-2828
Editore: Academic Press
DOI: 10.1016/j.yjmcc.2018.07.248

Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and Disease

Autori: Dan Lindholm, Laura Korhonen, Ove Eriksson, Sulev Kõks
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 5, 2017, ISSN 2296-634X
Editore: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2017.00048

Altered Expression Profile of IgLON Family of Neural Cell Adhesion Molecules in the Dorsolateral Prefrontal Cortex of Schizophrenic Patients

Autori: Karina Karis, Kattri-Liis Eskla, Maria Kaare, Karin Täht, Jana Tuusov, Tanel Visnapuu, Jürgen Innos, Mohan Jayaram, Tõnis Timmusk, Cynthia S. Weickert, Marika Väli, Eero Vasar, Mari-Anne Philips
Pubblicato in: Frontiers in Molecular Neuroscience, Numero 11, 2018, ISSN 1662-5099
Editore: Frontiers Research Foundation
DOI: 10.3389/fnmol.2018.00008

Prostaglandin D2 Receptor DP1 Antibodies Predict Vaccine-induced and Spontaneous Narcolepsy Type 1: Large-scale Study of Antibody Profiling

Autori: Helle Sadam, Arno Pihlak, Anri Kivil, Susan Pihelgas, Mariliis Jaago, Priit Adler, Jaak Vilo, Olli Vapalahti, Toomas Neuman, Dan Lindholm, Markku Partinen, Antti Vaheri, Kaia Palm
Pubblicato in: EBioMedicine, Numero 29, 2018, Pagina/e 47-59, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2018.01.043

Recent advances in applying mass spectrometry and systems biology to determine brain dynamics

Autori: Enzo Scifo, Giulio Calza, Martin Fuhrmann, Rabah Soliymani, Marc Baumann, Maciej Lalowski
Pubblicato in: Expert Review of Proteomics, Numero 14/6, 2017, Pagina/e 545-559, ISSN 1478-9450
Editore: Future Drugs Ltd.
DOI: 10.1080/14789450.2017.1335200

A Short Tandem Repeat-Enriched RNA Assembles a Nuclear Compartment to Control Alternative Splicing and Promote Cell Survival

Autori: Karen Yap, Svetlana Mukhina, Gen Zhang, Jason S.C. Tan, Hong Sheng Ong, Eugene V. Makeyev
Pubblicato in: Molecular Cell, Numero 72/3, 2018, Pagina/e 525-540.e13, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2018.08.041

CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons

Autori: Eli-Eelika Esvald, Jürgen Tuvikene, Alex Sirp, Sudarshan Patil, Clive R. Bramham, Tõnis Timmusk
Pubblicato in: The Journal of Neuroscience, 2020, Pagina/e 0367-19, ISSN 0270-6474
Editore: Society for Neuroscience
DOI: 10.1523/jneurosci.0367-19.2019

Isoform-Specific Reduction of the Basic Helix-Loop-Helix Transcription Factor TCF4 Levels in Huntington's Disease.

Autori: Nurm K, Sepp M, Castany-Pladevall C, Creus-Muncunill J, Tuvikene J, Sirp A, Vihma H, Blake DJ, Perez-Navarro E, Timmusk T
Pubblicato in: eNeuro, 2021, ISSN 2373-2822
Editore: Society for Neuroscience
DOI: 10.1523/eneuro.0197-21.2021

Identification of two highly antigenic epitope markers predicting multiple sclerosis in optic neuritis patients.

Autori: Sadam H, Pihlak A, Jaago M, Pupina N, Rähni A, Toots M, Vaheri A, Nieminen JK, Siuko M, Tienari PJ, Palm K.
Pubblicato in: EBioMedicine, 2021, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2021.103211

Melanoma-specific antigen-associated antitumor antibody reactivity as an immune-related biomarker for targeted immunotherapies.

Autori: Rähni A, Jaago M, Sadam H, Pupina N, Pihlak A, Tuvikene J, Annuk M, Mägi A, Timmusk T, Ghaemmaghami AM, Palm K.
Pubblicato in: Commun Med, 2022, ISSN 2730-664X
Editore: Springer
DOI: 10.1038/s43856-022-00114-7

Differential patterns of cross-reactive antibody response against SARS-CoV-2 spike protein detected for chronically ill and healthy COVID-19 naïve individuals.

Autori: Jaago M, Rähni A, Pupina N, Pihlak A, Sadam H, Tuvikene J, Avarlaid A, Planken A, Planken M, Haring L, Vasar E, Baćević M, Lambert F, Kalso E, Pussinen P, Tienari PJ, Vaheri A, Lindholm D, Timmusk T, Ghaemmaghami AM, Palm K.
Pubblicato in: SciRep, 2022, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-022-20849-6

Analysis of RNA-containing compartments by hybridization and proximity labeling in cultured human cells

Autori: Karen Yap; Tek Hong Chung; Eugene V. Makeyev;
Pubblicato in: STAR Protocols, 2022, ISSN 2666-1667
Editore: Elsevier
DOI: 10.1016/j.xpro.2022.101139

Tuba8 drives Differentiation of Cortical Radial Glia into Apical Intermediate Progenitors by Tuning Modifications of Tubulin C Termini.

Autori: Ramos SI, Makeyev EV, Salierno M, Kodama T, Kawakami Y, Sahara S. Tuba
Pubblicato in: Dev Cell, Numero 15345807, 2020, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2020.01.036

High seroreactivity against SARS-CoV-2 Spike epitopes in a pre SARS-CoV-2 cohort: implications for antibody testing and vaccine design

Autori: Kaia Palm; Mariliis Jaago; Annika Rähnni, Nadezhda Pupina; Arno Pihlak; Helle Sadam; Annela Avarlaid; Anu Planken; Planken; Liina Haring; Eero Vasar; Miljana Bacevic; Eija Kalso; Pirkko J. Pussinen; Pentti J. Tienari;Antti Vaheri; Dan Lindholm; Tõnis Timmusk; Amir M. Ghaemmaghami;ni;
Pubblicato in: 2020
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.05.18.20105189

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