This Phase 1 (work package 2) required finding classes of high impact questions in the Drug R&D domain which we concluded had to be at the start of the Drug R&D process rather than towards the end, because for the latter, the confidentiality of data and regulatory hurdles are insurmountable for our short term goals. We needed to find an unmet (work packages 3, 4 & 5) need that was common across all Researchers in the domain whether they worked in Pharma, Biotech or Academic R&D. We needed a common process, which researchers know is incompletely thorough and where the consequences for lack of thoroughness are highly expensive. We needed to find a process which is all too frequently heavily manual but which would lend itself to new inexpensive technology – in this case 3-D printing of macrofluidics discovered with a local partner (work packages 6, 7 & 8) – such that the most budget pressed academic could use it. Assuming that we then bundled this inexpensive open source macrofluidics hardware platform with the semantic query system we will build, we had one final hurdle to overcome. For decades, data query companies have tried to sell business and scientific users graphical interfaces that sought to automate the work that programmers do but have failed to have great success. Researchers instead frequently choose to do all of their work ‘inside’ spreadsheets. In this Phase 1 we have discovered a method to overcome this market adoption problem.