Specialized Ribosomes for Neuronal Protein Synthesis

Project Information

NeuroRibo

Grant agreement ID: 743216

DOI 10.3030/743216

Project closed

EC signature date 17 July 2017

Start date 1 August 2017

End date 31 July 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 348 483,00

EU contribution € 2 348 483,00

Coordinated by

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

Publications

Peer reviewed articles (17)

Differential regulation of local mRNA dynamics and translation following long-term potentiation and depression

Author(s): Paul G. Donlin-Asp, Claudio Polisseni, Robin Klimek, Alexander Heckel, Erin M. Schuman
Published in: Proceedings of the National Academy of Sciences (PNAS), 2021, ISSN 1091-6490
Publisher: National Academy of Science
DOI: 10.1073/pnas.2017578118

How mRNA Localization and Protein Synthesis Sites Influence Dendritic Protein Distribution and Dynamics

Author(s): Yombe Fonkeu, Nataliya Kraynyukova, Anne-Sophie Hafner, Lisa Kochen, Fabio Sartori, Erin M. Schuman, Tatjana Tchumatchenko
Published in: Neuron, Issue Volume 103, Issue 6, 2019, Page(s) 1109-1122.e7, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2019.06.022

The prevalence and specificity of local protein synthesis during neuronal synaptic plasticity

Author(s): Chao Sun, Andreas Nold, Claudia M. Fusco, Vidhya Rangaraju, Tatjana Tchumatchenko, Mike Heilemann, Erin M. Schuman
Published in: Science Advances, 2021, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abj0790

The switch-like expression of heme-regulated kinase 1 mediates neuronal proteostasis following proteasome inhibition

Author(s): Beatriz Alvarez-Castelao, Susanne tom Dieck, Claudia M Fusco, Paul Donlin-Asp, Julio D Perez, Erin M Schuman
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.52714

A genetically encodable cell-type-specific protein synthesis inhibitor

Author(s): Maximilian Heumüller, Caspar Glock, Vidhya Rangaraju, Anne Biever, Erin M. Schuman
Published in: Nature Methods, Issue 16/8, 2019, Page(s) 699-702, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-019-0468-x

Spatially Stable Mitochondrial Compartments Fuel Local Translation during Plasticity

Author(s): Vidhya Rangaraju, Marcel Lauterbach, Erin M. Schuman
Published in: Cell, Issue 176/1-2, 2019, Page(s) 73-84.e15, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.12.013

Alternative 3′ UTRs Modify the Localization, Regulatory Potential, Stability, and Plasticity of mRNAs in Neuronal Compartments

Author(s): Georgi Tushev, Caspar Glock, Maximilian Heumüller, Anne Biever, Marko Jovanovic, Erin M. Schuman
Published in: Neuron, Issue 98/3, 2018, Page(s) 495-511.e6, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2018.03.030

Local and global influences on protein turnover in neurons and glia

Author(s): Aline R Dörrbaum, Lisa Kochen, Julian D Langer, Erin M Schuman
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.34202

Cell-type-specific metabolic labeling, detection and identification of nascent proteomes in vivo

Author(s): Beatriz Alvarez-Castelao, Christoph T. Schanzenbächer, Julian D. Langer, Erin M. Schuman
Published in: Nature Protocols, Issue 14/2, 2019, Page(s) 556-575, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-018-0106-6

Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments

Author(s): Anne-Sophie Hafner, Paul G. Donlin-Asp, Beulah Leitch, Etienne Herzog, Erin M. Schuman
Published in: Science, Issue 364/6441, 2019, Page(s) eaau3644, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aau3644

Long and Repeat-Rich Intronic Sequences Favor Circular RNA Formation under Conditions of Reduced Spliceosome Activity

Author(s): Mantian Wang, Jingyi Hou, Michaela Müller-McNicoll, Wei Chen, Erin M. Schuman
Published in: iScience, Issue 20, 2019, Page(s) 237-247, ISSN 2589-0042
Publisher: Cell Press
DOI: 10.1016/j.isci.2019.08.058

Local translation in neurons: visualization and function

Author(s): Christine E. Holt, Kelsey C. Martin, Erin M. Schuman
Published in: Nature Structural & Molecular Biology, Issue 26/7, 2019, Page(s) 557-566, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-019-0263-5

Monosomes actively translate synaptic mRNAs in neuronal processes

Author(s): Anne Biever, Caspar Glock, Georgi Tushev, Elena Ciirdaeva, Tamas Dalmay, Julian D. Langer, Erin M. Schuman
Published in: Science, Issue 367/6477, 2020, Page(s) eaay4991, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aay4991

The translatome of neuronal cell bodies, dendrites,and axons

Author(s): Caspar Glock, Anne Biever, Georgi Tushev, Belquis Nassim-Assir, Allison Kao, Ina Bartnik, Susanne tom Dieck, Erin M. Schuman
Published in: Proceedings of the National Academy of Sciences (PNAS), Issue 118 (43) e2113929118, 2021, ISSN 1091-6490
Publisher: National Academy of Science
DOI: 10.1073/pnas.2113929118

Full-length transcriptome reconstruction reveals a large diversity of RNA and protein isoforms in rat hippocampus

Author(s): Xi Wang, Xintian You, Julian D. Langer, Jingyi Hou, Fiona Rupprecht, Irena Vlatkovic, Claudia Quedenau, Georgi Tushev, Irina Epstein, Bernhard Schaefke, Wei Sun, Liang Fang, Guipeng Li, Yuhui Hu, Erin M. Schuman, Wei Chen
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-13037-0

Proteome dynamics during homeostatic scaling in cultured neurons

Author(s): Aline Ricarda Dörrbaum, Beatriz Alvarez-Castelao, Belquis Nassim-Assir, Julian D Langer, Erin M Schuman
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.52939

Neuronal ribosomes exhibit dynamic and context-dependent exchange of ribosomal proteins

Author(s): Claudia M. Fusco, Kristina Desch, Aline R. Dörrbaum, Mantian Wang, Anja Staab, Ivy C. W. Chan, Eleanor Vail, Veronica Villeri, Julian D. Langer, Erin M. Schuman
Published in: Nature Communications (Nat Commun), Issue 6127, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26365-x