Cel Optoacoustic imaging is a highly scalable and versatile method that can be used for optical resolution microscopy (OR-OAM) at superficial depth yet can be adapted for tomographic imaging with ultrasonic resolution at centimeter penetration scale. However, the imaging speed of OR-OAM is slow as far as concerned with acquisition of volumetric data, which greatly restricts its usage in applications involving dynamic biological processes. In this MSCA project, we propose to develop a new approach using multifocal structured illumination in conjunction with a spherical ultrasonic array detection to achieve real-time volumetric optoacoustic imaging in both optical and acoustic resolution modes. Several challenges are to be addressed to reach these objectives. Firstly, a multifocal structured illumination system with two identical beamsplitting gratings will be designed and fabricated. Secondly, optoacoustic signal unmixing method for the spherical ultrasonic array detection geometry will be developed and image reconstruction algorithms based on the unmixed signals devised. Thirdly, calibration methods for the proposed system will be investigated. Finally, real-time volumetric optoacoustic imaging will be demonstrated in living animals With the proposed method, real-time volumetric imaging at multiple penetration scales can be accomplished, making it possible to study dynamic functional, kinetic and metabolism parameters at the cellular, organ and whole organism level. By opening new possibilities for visualization of multi-scale dynamics not attainable with existing imaging modalities, the new method will broadly affect both pre-clinical and clinical imaging in the fields of in vivo cell tracking, targeted molecular imaging, studies of tumor dynamics and neovascularization, functional brain imaging. Dziedzina nauki natural sciencesphysical sciencesopticsmicroscopynatural sciencesmathematicspure mathematicsgeometry Program(-y) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Temat(-y) MSCA-IF-2016 - Individual Fellowships Zaproszenie do składania wniosków H2020-MSCA-IF-2016 Zobacz inne projekty w ramach tego zaproszenia System finansowania MSCA-IF-EF-ST - Standard EF Koordynator UNIVERSITAT ZURICH Wkład UE netto € 71 442,00 Adres RAMISTRASSE 71 8006 Zurich Szwajcaria Zobacz na mapie Region Schweiz/Suisse/Svizzera Zürich Zürich Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 71 442,01 Uczestnicy (1) Sortuj alfabetycznie Sortuj według wkładu UE netto Rozwiń wszystko Zwiń wszystko HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH Zakończenie uczestnictwa Niemcy Wkład UE netto € 100 018,80 Adres INGOLSTADTER LANDSTRASSE 1 85764 Neuherberg Zobacz na mapie Region Bayern Oberbayern München, Landkreis Rodzaj działalności Research Organisations Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 100 018,80