Objectif Vector-borne diseases represent one of the greatest public health challenges. Their incidence and their geographical range have dramatically increased over the past several decades. Due to the lack of protective vaccines, the control of transmission by targeting the mosquito vectors is the only affordable measure. However, mosquito vectors experience a very intense selective pressure from insecticides, which has led ultimately to the selection of insecticide resistance in many vector species. Alternative control strategies that are species-specific and environmentally friendly are being developed. Among them, the use of the symbiotic bacteria Wolbachia as sterilizing agent of mosquito populations through the incompatible insect technique (IIT) appears promising. Furthermore, it was shown that insecticides as well as Wolbachia can affect the infection of mosquitoes by pathogens, and thus their transmission. An important question is how mosquitoes' adaptations to insecticides and to Wolbachia influence the vector competence for pathogens? This proposal addresses this question in the context of the emergence of Chikungunya worldwide in order to sustainably control its transmission with current and prospective vector control tools. It addresses in particular the question whether there are any interactions between insecticide resistance and symbiotic Wolbachia infection that might significantly affect the vector competence of Aedes albopictus for Chikungunya virus. Characterizing the genes likely involved in vector competence and how they can be modulated to alter this trait will provide valuable data for management of transmission control strategies. It will allow a more rational use of insecticides, as well as the development of alternative control methods based on Wolbachia; both approaches are crucial in the context of widespread insecticide resistance. Champ scientifique medical and health scienceshealth sciencesinfectious diseasesmalariamedical and health scienceshealth sciencespublic healthnatural sciencesbiological sciencesmicrobiologyvirologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesnatural sciencesbiological scienceszoologyinvertebrate zoology Mots‑clés Chikungunya Tiger mosquito insecticide resistance Wolbachia infection transmission Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Thème(s) MSCA-IF-2016 - Individual Fellowships Appel à propositions H2020-MSCA-IF-2016 Voir d’autres projets de cet appel Régime de financement MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF) Coordinateur CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Contribution nette de l'UE € 185 076,00 Adresse RUE MICHEL ANGE 3 75794 Paris France Voir sur la carte Région Ile-de-France Ile-de-France Paris Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 185 076,00