Objectif Head direction (HD) cells provide directional information during spatial navigation and thus act as aninternal compass. The goal of this study is to understand how the HD circuit creates a lasting neural trace oftransient directional changes. Cells selective for HD have been identified in several brain regions, includingthe retrosplenial cortex (RSC), and display persistent activity in response to transient vestibular turningcues. Although a well-established theoretical framework proposes an elegant circuitry for achieving thisself-sustaining activity, biological evidence for such a circuit is lacking. Studies of HD circuitry have facedsignificant challenges due to the necessity of functional monitoring at large and small scales in vivo, andprecise stimulus control. This study will take advantage of recent advances allowing the targeting of specificcells and their inputs for chronic two-photon imaging in the awake, head-fixed, and passively rotated mouse.Experiments will aim to (1) determine the spatial and temporal organization of HD-tuned responses in RSC,and (2) functionally characterize the presynaptic inputs of HD cells. This information will validate or rejecta prominent theory of neural network organization, and provide unprecedented insight into a poorlyunderstood but critical brain function. Champ scientifique natural sciencesbiological scienceszoologymammalogyprimatologynatural sciencesbiological sciencesneurobiologycognitive neurosciencenatural scienceschemical sciencesinorganic chemistryalkaline earth metalssocial sciencessocial geographytransportnavigation systemsnatural sciencescomputer and information sciencesartificial intelligencecomputational intelligence Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Thème(s) MSCA-IF-2016 - Individual Fellowships Appel à propositions H2020-MSCA-IF-2016 Voir d’autres projets de cet appel Régime de financement MSCA-IF-EF-ST - Standard EF Coordinateur UNIVERSITETET I OSLO Contribution nette de l'UE € 196 400,40 Adresse PROBLEMVEIEN 5-7 0313 Oslo Norvège Voir sur la carte Région Norge Oslo og Viken Oslo Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 196 400,40