Project description DEENESFRITPL Fungal infections: unveiling the interplay with the host Fungi are usually harmless to human health and can be found on the skin and in body cavities. However, under specific conditions fungi such as the Candida species may cause infections that can be life-threatening. The EU-funded FunHoMic project focuses on understanding the interplay between the infectious fungi, the host immune system and host microbiota. To investigate how this interaction determines the severity of a fungal infection, the consortium will develop an organ-on-a-chip approach and undertake genetic analysis to identify biomarkers and other determinants associated with fungal infectivity. Results will pave the way towards better stratification of fungal infections and tailored therapeutic interventions. Show the project objective Hide the project objective Objective Fungal infections have a major impact on human health, infecting about 2 billion people and killing more people each year than malaria or breast cancer. In particular, Candida species impose a high clinical and economic burden upon the European population. They frequently cause fatal hospital-acquired bloodstream infections. They also cause oral thrush and vaginitis. Most women have suffered an episode of vulvovaginal candidiasis, with ~8% enduring recurrent infections. The initiation and severity of a Candida infection depends on an intricate interplay between the infecting fungal strain and the individual’s immune status and microbiota, all of which can display significant variability. Therefore, for the first time, FunHoMic integrates experts in fungal pathogenesis, immunology, microbial ecology and ‘omics technologies to train 13 Early Stage Researchers (ESRs) who will define and exploit this Fungal-Host-Microbiota interplay to identify novel biomarkers (fungal or host genetic polymorphisms, microbiota profiles, metabolites or immune markers) for the stratification of a patient’s risk of serious fungal infection. This will pave the way for precision medicine in patient management through preventive or therapeutic interventions using antifungals, immune modulators or Live Biotherapeutic Products (LBPs). FunHoMic ESRs will gain broad interdisciplinary skills plus a translational mindset through our integrated, inter-sectoral training program. This will allow Europe to remain at the forefront of translational research in the field of medical mycology. To achieve this vision FunHoMic unites academic partners from France, Germany, The Netherlands, Switzerland, Spain and UK, a French Technology Research Institute with cutting-edge ‘omics technology platforms and three SMEs from The Netherlands, Belgium and France that bring unrivalled organ-on-chip and gastro-intestinal tract simulation technologies and expertise in the development and exploitation of innovative LBPs. Fields of science natural sciencesbiological sciencesmicrobiologybacteriologynatural sciencesbiological sciencesmicrobiologymycologymedical and health sciencesbasic medicineimmunologymedical and health scienceshealth sciencespersonalized medicineengineering and technologyother engineering and technologiesmicrotechnologyorgan on a chip Keywords molecular medical mycology Candida microbiota omics technologies immunology fungal infections ex vivo infection models animal models Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.1. - Fostering new skills by means of excellent initial training of researchers Topic(s) MSCA-ITN-2018 - Innovative Training Networks Call for proposal H2020-MSCA-ITN-2018 See other projects for this call Funding Scheme MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN) Coordinator INSTITUT PASTEUR Net EU contribution € 549 604,08 Address RUE DU DOCTEUR ROUX 25-28 75724 Paris France See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 549 604,08 Participants (11) Sort alphabetically Sort by Net EU contribution Expand all Collapse all LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-INSTITUT Germany Net EU contribution € 505 576,80 Address BEUTENBERG STRASSE 11A 07745 Jena See on map Region Thüringen Thüringen Jena, Kreisfreie Stadt Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 505 576,80 STICHTING RADBOUD UNIVERSITEIT Participation ended Netherlands Net EU contribution € 154 944,93 Address HOUTLAAN 4 6525 XZ Nijmegen See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 154 944,93 UNIVERSITAT ZURICH Switzerland Net EU contribution € 281 276,64 Address RAMISTRASSE 71 8006 Zurich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 281 276,64 FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA Spain Net EU contribution € 250 904,88 Address PASSEIG VALL D HEBRON 119-129 EDIFICIO DE RECERCA 08035 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 250 904,88 THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN United Kingdom Net EU contribution € 606 345,12 Address KING'S COLLEGE REGENT WALK AB24 3FX ABERDEEN See on map Region Scotland North Eastern Scotland Aberdeen City and Aberdeenshire Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 606 345,12 BIOASTER FONDATION DE COOPERATION SCIENTIFIQUE France Net EU contribution € 274 802,04 Address 40 AVENUE TONY GARNIER 69007 Lyon See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Rhône Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 274 802,04 MIMETAS BV Netherlands Net EU contribution € 265 619,88 Address DE LIMES 7 2342 DH Oegstgeest See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 265 619,88 PRODIGEST Belgium Net EU contribution € 256 320,00 Address TECHNOLOGIEPARK 3 9052 Gent Zwijnaarde See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 256 320,00 BIOSE Participation ended France Net EU contribution € 79 921,59 Address RUE DES FRERES LUMIERES 15130 Arpajon Sur Cere See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Auvergne-Rhône-Alpes Auvergne Cantal Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 79 921,59 STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM Netherlands Net EU contribution € 110 674,95 Address GEERT GROOTEPLEIN 10 ZUID 6525 GA Nijmegen See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 110 674,95 NEXBIOME THERAPEUTICS France Net EU contribution € 194 880,45 Address 22 ALLEE ALAN TURING 63000 Clermont Ferrand See on map Region Auvergne-Rhône-Alpes Auvergne Puy-de-Dôme Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 194 880,45 Partners (5) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. UNIVERSITE CLERMONT AUVERGNE France Net EU contribution € 0,00 Address 49 BD FRANCOIS MITTERRAND 63000 Clermont Ferrand See on map Region Auvergne-Rhône-Alpes Auvergne Puy-de-Dôme Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. UNIVERSITEIT GENT Belgium Net EU contribution € 0,00 Address SINT PIETERSNIEUWSTRAAT 25 9000 Gent See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. UNIVERSITEIT LEIDEN Netherlands Net EU contribution € 0,00 Address RAPENBURG 70 2311 EZ Leiden See on map Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. UNIVERSITE PARIS CITE France Net EU contribution € 0,00 Address 85 BD SAINT GERMAIN 75006 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. EVOTEC (UK) LIMITED United Kingdom Net EU contribution € 0,00 Address 114 INNOVATION DRIVE, MILTON PARK MILTON OX14 4RZ Abingdon Oxfordshire See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data
