Deliverables
Report describing the methodologies adopted if needed to biologically functionalize the different scaffolds in order to increase their biocompatibility and bioactivity Task 33
Communication (CP) and Dissemination (DP) plan revisionRevision of the communication and dissemination plans
Report on the Communication (CP) and Dissemination (DP) plan follow upFinal document reporting on the Communication and Dissemination plans accomplishement
Management plan and ProtectionDefine the Knowledge management plan and Protection of the results obtained during the project.
Report on organs toxicityReport on the hepatotoxicity renal toxicity and pulmonary toxicity
Electrical circuit specificationsA report describing the electrical circuit specifications able to control the amount of charge the direction of its transfer its shape and the peak voltage being developed in the Task 21 will be delivered
Report on biocompatibility in vitroReport on in vitro biocompatibility of the scaffolds in the presence of the cells under study Details about cell viability proliferation structure and differentiation assessed at different time points will be detailed results obtained under Task 42
Electronic controller board state of the artA report describing the state of the art and current specifications about electronic controller board specificity.
Preliminary evaluation of biological functionalization of the scaffoldsReport describing the first biological functionalization of the different scaffolds produced and characterized in tasks 31 and 32
Synaptogenesis and neuritogenesisReport on the mechanism behavior of the neurons seeded in the adECMGBM scaffolds will be delivered at the end of Task 44 This report will also include results from other tasks namely 45 and 47 due to the close interrelation between them
Growth and differentiation of primary ENPCs in the adECM/GBM scaffoldsReport describing the results obtained on the growth and differentiation of primary ENPCs in the different developed adECMGBM scaffolds under Tasks 42 and 43
Report describing the preparation of different shaped GBM/adECM scaffoldsReport describing in detail the preparation methodologies and characterization of the different shaped GBMadECM scaffolds produced These activities will be done in Tasks 31 and 32
Communication (CP) and Dissemination (DP) planCommunication (CP) and Dissemination (DP) plan will be prepared.
Preliminary study about electrode and scaffold connectionReport describing preliminary results about the electrode connection between the device and the scaffold through a graphenebased ink developed in Task 23
Response of different neural cell linesReport describing the response of different neural cell lines
State of the art analysisA report describing the state of the art and current specifications about the electrical circuit foreseen for the particular applications in this project.
Device connection to the scaffoldReport describing the electrode connection between the device with the scaffold based on a graphenebased ink developed in Task 23
Report on immune response in vitroReport on immune response in vitro studies with macrophages innate immune system and T lymphocytes adaptive response will be detailed Task 46
Preliminar report on production and characterization of scaffoldsPreliminary report describing the preparation methodologies and characterization of GBM/adECM scaffolds. These activities will be done in Tasks 3.1 and 3.2
Finalization of biocompatibility and efficacy studies in the injured SC after local exposure to the scaffold matrices in small preclinical modelsFinalization of biocompatibility and efficacy studies in the injured SC after local exposure to the scaffold matrices in small preclinical models This report will bring together all results related to the in vivo studies conducted with the optimized scaffolds with and without electrical stimulation Task 53
To comply with the Open Research data Pilot, a Data Management Plan will be prepared, which will be a dynamic document that will be updated during the project execution.
Data Management plan revision 2Revision and update if necessary of the previously implemented and revised Data Management Plan
Data Management plan revision 1Revision and update if necessary of the previously implemented Data Management Plan
The NeuroStimSpinal logo and Website will be created.
Deliver of the isolated ENPCs necessary for subsequent tasks
Workshop organization 1A first workshop will be organized dedicated to the thematic of the NeuroStimSpinal project Experts in the field will be invited to participate and all the project members will present ongoing results
Publications
Author(s):
Marques, Paula
Published in:
Advanced Healthcare Materials, Issue 7, 2023, Page(s) 2300828 (1 of 15), ISSN 2192-2659
Publisher:
World Scientific
DOI:
10.1002/adhm.202300828
Author(s):
Alberto Polo-Montalvo, Mónica Cicuéndez, Laura Casarrubios, Nathalie Barroca, Daniela da Silva, María José Feito, Rosalía Diez-Orejas, María Concepción Serrano, Paula A. A. P. Marques and María Teresa Portolés
Published in:
Nanoscale, 2023, Page(s) 17173-17183, ISSN 2040-3372
Publisher:
Royal Society of Chemistry
DOI:
10.1039/d3nr03145d
Author(s):
André F. Girão, María Concepcion Serrano, António Completo, and Paula A. A. P. Marques
Published in:
ACS Nano, 2022, ISSN 1936-0851
Publisher:
American Chemical Society
DOI:
10.1021/acsnano.2c04756
Author(s):
Marques, Paula
Published in:
Biomaterials Advances, Issue 22, 2023, Page(s) 213351, ISSN 2772-9508
Publisher:
Elsevier
DOI:
10.1016/j.bioadv.2023.213351
Author(s):
Marques, Paula
Published in:
Chemical Engineering Journal, Issue 20, 2023, Page(s) 144980, ISSN 1873-3212
Publisher:
Elsevier
DOI:
10.1016/j.cej.2023.144980
Author(s):
Phanee Manganas, Paraskevi Kavatzikidou, Antonis Kordas, Eleftheria Babaliari, Emmanuel Stratakis
and Anthi Ranella
Published in:
Frontiers in Celluluar Neuroscience, 2022, ISSN 1662-5102
Publisher:
Frontiers Research Foundation
DOI:
10.3389/fncel.2022.948454
Author(s):
Cicuéndez, M.; Casarrubios, L.; Barroca, N.; Silva, D.; Feito, M.J.; Diez‐Orejas, R.; Marques, P.A.A.P.; Portolés, M.T.
Published in:
International Journal of Molecular Science, 2021, Page(s) 6701 (16 pages), ISSN 1422-0067
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms22136701
Author(s):
Kest Verstappen, René Aquarius, Alexey Klymov, Kimberley Wever, Lyan Damveld, Sander C.G. Leeuwenburgh, Ronald H.M.A. Bartels, Carlijn R Hooijmans, X Frank Walboomers
Published in:
Tissue Engineering Part B: Reviews, 2021, ISSN 1937-3368
Publisher:
Mary Ann Liebert Inc.
DOI:
10.1089/ten.teb.2021.0194
Author(s):
Babaliari, E.; Kavatzikidou, P.; Mitraki, A.; Papaharilaou, Y.; Ranella, A.; Stratakis, E.
Published in:
Biomaterials Science, Issue 7, 2020, Page(s) 1334-1344, ISSN 2047-4849
Publisher:
Royal Society of Chemistry
DOI:
10.1039/d0bm01218a
Author(s):
Mónica Cicuéndez, Laura Casarrubios, María José Feito, Iratxe Madarieta, Nerea Garcia-Urkia,
Olatz Murua, Beatriz Olalde, Nerea Briz, Rosalía Diez-Orejas, María Teresa Portolés
Published in:
Journal of Fungi, Issue 1, 2021, Page(s) 392, ISSN 2309-608X
Publisher:
MDPI
DOI:
10.3390/jof7050392
Author(s):
L. Papadimitriou, P. Manganas, A. Ranella, E. Stratakis
Published in:
Materials Today Bio, Issue 6, 2020, Page(s) 100043, ISSN 2590-0064
Publisher:
Elsevier
DOI:
10.1016/j.mtbio.2020.100043
Author(s):
Cicuéndez, M., Casarrubios, L., Feito, M.J., Madarieta, I., Garcia-Urkia, N., Murua, O., Olalde, B.
Briz, N., Diez-Orejas, R., Portolés, M.T.
Published in:
International Journal of Molecular Sciences, Issue 1, 2021, Page(s) 3847, ISSN 1422-0067
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms22083847
Author(s):
María José Feito, Mónica Cicuéndez, Laura Casarrubios, Rosalía Diez-Orejas, Sara Fateixa, Daniela Silva, Nathalie Barroca, Paula A. A. P. Marques, María Teresa Portolés
Published in:
International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms231810625
Author(s):
Marques, Paula
Published in:
Biomaterials Advances, Issue 9, 2023, Page(s) 213353, ISSN 2772-9508
Publisher:
Elsevier
DOI:
10.1016/j.bioadv.2023.213353
Author(s):
Pereira, António; Marques, Paula; Coelho, Margarida; Completo, António; Neto, Fernando
Published in:
Issue 22, 2022
Publisher:
University of Aveiro
DOI:
10.48528/2smr-sn15
Author(s):
Latifah Al-Maghrabi; Patrícia Martins; Daniela Silva; Guilherme Gil; Nathalie Barroca; Olatz Murua; Beatriz Olalde; Luís Alves; Paulo Pedreiraa, Pedro Fonseca, Philip LeDuc, Paula Marques
Published in:
IEEE International Symposium on Circuits and Systems (ISCAS), 2022, ISBN 978-1-6654-8485-5
Publisher:
IEEE
DOI:
10.1109/iscas48785.2022.9937411
Author(s):
Pereira, António; Marques, Paula; Coelho, Margarida; Completo, António; Neto, Fernando
Published in:
TEchMA2021: 4th International Conference on Technologies for the Wellbeing and Sustainable Manufacturing Solutions: book of abstracts, Issue 9, 2021, Page(s) 27 and 30, ISBN 978-972-789-667-7
Publisher:
UA Editora, Universidade de Aveiro
DOI:
10.34624/7q83-ay77
Author(s):
Daniela Silva, Joana Couto, Ângela Semitela, Susana C. Pinto, Sandra I. Vieira, Paula
A.A.P. Marques, Nathalie Barroca
Published in:
TEchMA 2023– 6th International Conference on Technologies for the Wellbeing and Sustainable Manufacturing Solutions, 2023, Page(s) 65, ISBN 978-972-789-858-9
Publisher:
UA Editora Universidade de Aveiro
DOI:
10.48528/tspw-yj21
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