IN VITRO TOXICOLOGICAL STUDIES AND REAL TIME ANALYSIS OF RESIDUES IN FOOD

Exploitable results

Rapid, low cost in-vitro toxicological test and analytical test methods were developed for the screening of food contaminants that did not involve extensive pretreatment procedures. In a series of workshops scientific papers were presented and the subjects ranged from instrumental approaches to residue analysis to detailed analytical procedures for defined classes of compounds or individual xenobiotics. These papers present methods for real-time analysis of a number of veterinary drugs. It has also been shown that a number of toxicological in vitro methods can be used to study specific aspects of biotransformation, bioavailability and cytotoxicity of foreign compounds. A special coordinated action has been developed concerning the detection and toxicological screening of beta-agonists. Moreover new strategies have been proposed regarding the application of toxicological in-vitro methods for registration requirements for veterinary drugs. It may be concluded that studies in food producing animals with radiolabelled material can substantially be reduced and replaced by in-vitro studies. Finally one of the most significant accomplishments of this Action is that during its course an organic network has been formed between the analytical and toxicological participating laboratories, which has already resulted in further joint research activities.

Exploitable results

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