Development of second generation vaccines against parvoviruses

Informations projet

N° de convention de subvention: BIOT0256

Projet clôturé

Date de début 1 Février 1991

Date de fin 31 Janvier 1994

Financé au titre de

• Specific research and technological development programme (EEC) in the field of biotechnology (BRIDGE), 1990-1994

Coût total € 0,00

Contribution de l’UE Aucune donnée

Coordonné par

INMUNOLOGIA Y GENETICA APLICADA SA
Spain

Résultats exploitables

Design of synthetic (peptide) molecules that mimic the binding sites ligand and receptor or antigen and antibody)

For canine parvovirus a peptide was defined, using PEPSCAN, which is able to induce full protection in the target animal (ie canines and mink). This is the first example of a fully synthetic vaccine able to induce full protection. The same peptide was used to be exposed on a recombinant plant virus (CPMV). This recombinant plant virus was shown to protect the target animal fully against disease. As such this is the first plant produced vaccine that is shown to protect the target animal.