Objective 1) TO INVESTIGATE THE USE OF COLD-STRESS AS AN AID TO REVEALING LATENT RENAL DISFUNCTION FROM CADMIUM EXPOSURE. 2) TO STUDY THE DISTRIBUTION OF LABELLED VANADIUM IN MICE, RATS AND PREGNANT RATS. 1) BIOCHEMICAL STUDIES ARE CARRIED OUT ON RATS EXPOSED TO AND UNEXPOSED TO CADMIUM. THE STUDIES ARE UNDERTAKEN BEFORE AND THE APPLICATION OF COLD-STRESS. BIOCHEMICAL ASPECTS INVESTIGATED INCLUDE THE EXPLORATION OF THE PERIPHERIC ADVENERGIC SYSTEM TO OBTAIN INFORMATION CONCERNING THE ROLE OF CADMIUM IN THE RELEASE OF CATECHOLAMINES. 2) THE DISTRIBUTION OF LABELLED VANADIUM IN MICE, RATS AND PREGNANT RATS ARE STUDIED WITH RADIOISOTOPIC TECHNIQUES. DISTRIBUTION IN GONADS, ADRENAL GLADS, BRAIN, ETC. ARE INVESTIGATED. IN PREGNANT RATS, TRANSPLACENTAL TRANSFER AND FOETAL LOCALISATION ARE EXAMINED AND THE PRESENCE OF VANADIUM IN MILK IS DETERMINED. THE EFFECT OF IRON EXPOSURE ON THE KINETICS OF VANADIUM ARE ALSO INVESTIGATED. Programme(s) PRE-ENVPROT 3C - Sectoral research and development programme (EEC) in the field of environment (environmental protection and climatology) - indirect and concerted actions - Environmental protection -, 1981-1985 Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator École Nationale Vétérinaire de Lyon EU contribution No data Address 1 avenue Bourgelat 69280 Marcy-l'Etoile France See on map Total cost No data
