Objective 1. TO STUDY THE CARCINOGENIC POTENTIAL OF VARIOUS MINERAL FIBERS, BOTH NATURAL ACID-TREATED. 2. TO ESTABLISH CORRELATION BETWEEN THE EFFECT OF THE FIBERS ON CELLS IN-VITRO AND THEIR CARCINOGENIC ACTIVITY IN EXPERIMENTAL ANIMALS. THIS PROJECT IS A DEVELOPMENT OF RESEARCH CARRIED OUT UNDER THE PREVIOUS R&D PROGRAMME IN THE FIELD OF ENVIRONMENT. THE RESEARCH IS CARRIED OUT USING 500 RATS. THE ANIMALS ARE GIVEN A SINGLE DOSE OF 20 MG BY INTRA-PLEURAL INJECTION. ANIMALS ARE KEPT UNTILL DEATH AND ARE THEN GIVEN AUTOPSY; THE ORGANS ARE FIXED BY STANDARD METHODS. AN ANATOMO-PATHOLOGICAL EXAMINATION OF THE ORGANS IS UNDERTAKEN BY OPTICAL MICROSCOPY. 35 ANIMALS ARE USED FOR EACH OF FIBRE, WITH ONE GROUP FOR CONTROL. Programme(s) PRE-ENVPROT 3C - Sectoral research and development programme (EEC) in the field of environment (environmental protection and climatology) - indirect and concerted actions - Environmental protection -, 1981-1985 Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator ASSOCIATION CLAUDE BERNARD EU contribution No data Address Rue Scipion, 13 75005 PARIS France See on map Total cost No data
