Objectif Problems to be solvedThe objectives of this project for industrial, life science oriented marine product research are aiming at natural products as leads and/or enzymes, which are: target specific, aiming at defined classes of industrial life science effects, minimise unwanted side effects, relying on bio-sedimentary sources which are accessible, in a technical, economic and institutional sense, also for repeated re-sampling and re-supply, amount to products obtainable by cultivation or other bioengineering, and be obtained in sufficient quantities in a cost effective and environmental manner.Scientific objectives and approachSediments containing typical marine bacteria, known or expected to be producers of secondary metabolites from selected coastal, shelf and deep-sea areas of the North-East Atlantic and other open ocean regions are to be compared. Sedimentary-microbiological and symbiotic interactions, constituting factors of the sea floor in all water depth, are investigated and quantified. Sediment samples from an enclosed sea with oceanographic-environmental parameters different from the open ocean, the Mediterranean, and the eastern Mediterranean in particular, are special regional targets. Additional steps are cultivation experiments in the lab, isolation and pre-screening. Further tasks are the study of cultivation opportunities in the ocean, characterisation of bacteria and their secondary metabolites, structure elucidation, lead oriented multi-screening and bioassays. A general evaluation of responsible uses by life science industries and of existing and forthcoming rules and regulations will complement the research on the commercial and regulatory side. Application and adaptation of well-proven methods and necessary new developments of marine sampling and in-site monitoring methods and equipment is a basic marine technology requirement. But also the logistics, the political and financial implications of oceanic bio-prospecting are important subtasks in finding optimised search strategies: where to look, how, and with whom, how to process samples, obtain and optimise cultures for lead identification in a cost effective and environmentally acceptable way, fast and reliably, from sedimentary micro organisms in the ocean.Expected impactsMain results are: optimised marine search strategies based on marine bio-sedimentary ecosystems, and on adapted and new methods and tools, identification of micro-organisms, culturable at normal pressure, and specialists, productivity: which organism grow under which conditions and produces enzymes and/or secondary metabolites, number of hits, and lead candidates, concept for an eventual industrial use of ocean sediment micro organisms in a safe and environmentally responsible approach. Champ scientifique natural sciencesbiological sciencesmicrobiologybacteriologysocial scienceseconomics and businesseconomicsproduction economicsproductivitynatural sciencesbiological sciencesecologyecosystemsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programme(s) FP5-EESD - Programme for research, technological development and demonstration on "Energy, environment and sustainable development, 1998-2002" Thème(s) 1.1.4.-3. - Key action Sustainable Marine Ecosystems Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur TECHNISCHE UNIVERSITAET BERLIN Contribution de l’UE Aucune donnée Adresse Mnller Breslau Strasse -- Scheuseninsel 10623 Berlin Allemagne Voir sur la carte Coût total Aucune donnée Participants (5) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire ANAGNOSTEC GMBH Allemagne Contribution de l’UE Aucune donnée Adresse Frankenfeider Chaussee 2 Im Biotechnologiepark 14943 Luckenwalde Voir sur la carte Coût total Aucune donnée GALILAEUS OY Finlande Contribution de l’UE Aucune donnée Adresse Kairiskulmantie 10 KAARINA Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS Grèce Contribution de l’UE Aucune donnée Adresse Panepistimiou 30 10679 ATHENS Voir sur la carte Coût total Aucune donnée SYNGENTA CROP PROTECTION AG Suisse Contribution de l’UE Aucune donnée Adresse 4002 BASEL Voir sur la carte Coût total Aucune donnée TECHNISCHE UNIVERSITAET BERLIN Allemagne Contribution de l’UE Aucune donnée Adresse Franklinstrasse 29 10587 Berlin Voir sur la carte Coût total Aucune donnée