Objective Clinical data from radiotherapy and experimental evidence obtained in vitro demonstrate the existence of inter-individual variation in response to ionising irradiation. The contribution of age, genetic polymorphism and environmental factors to these variations is still unknown. We propose to identify cellular phenotypes, related to individual radiosensitivity. This will permit the identification of involved functional and positional candidate genes, whose polymorphisms actually modulate individual radiosensitivity. The proposed approach is based on the exploitation of the unique GENEPI biological resource, the use of two recently validated, quantitative in vitro assays of radiosensitivity, and on the application of state-of-the-art gene expression profiling technology. Results of the study are intended to lead to the development of a predictive test for individual radiosensitivity, capable of identifying persons at risk. Fields of science natural sciencesbiological sciencesgenetics Programme(s) FP5-EAECTP C - Research and training programme (Euratom) in the field of nuclear energy (1998 to 2002) Topic(s) 2.1.3.-1.1. - Risk estimates for exposures at low dose and low dose rate Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator FONDATION JEAN DAUSSET - CENTRE D'ETUDE DU POLYMORPHISME HUMAIN EU contribution No data Address Rue Juliette Dodu 27 75010 PARIS France See on map Total cost No data Participants (2) Sort alphabetically Sort by EU Contribution Expand all Collapse all BELGIAN NUCLEAR RESEARCH CENTRE Belgium EU contribution No data Address Boeretang 200 2400 MOL See on map Total cost No data COMMISSARIAT A L'ENERGIE ATOMIQUE France EU contribution No data Address Avenue du General Leclerc 60-68 92265 FONTENAY AUX ROSES See on map Total cost No data