Cel Research objectives and content Objective: The migration of ions through membranes in biological cells is of prime importance in life processes, and yet information regarding the various mechanisms involved has been deduced without a knowledge of the structure and dynamics of the ionophores and ion channels, embedded within the membranes. In recent years several surface analytical tools have emerged with the assistance of which one may obtain structural information concerning the arrangement of molecules on various interfaces. Such methods have been applied for probing the structure of Langmuir monolayers and phase transitions of these architectures at the air-liquid interface (via grazing incidence synchrotron X-ray diffraction, X-ray reflectivity, reflectance infra-red spectroscopy) and after transfer to solid support (via local probe techniques, transmission electron microscopy, etc.). In this project we plan to design and analyze model systems of membranes at interfaces and probe the structure, and hopefully ion transport properties, of ion channel molecules and ionophores incorporated within these artificial "membranes". The ion transport molecule we shall focus on valinomycin, a naturally occurring ionophore, as well as synthetic ion-channel molecules such as the cyclic peptides prepared by Ghadiri et al (1,2) Training content: The training at the Weizmann institute will enable L. Nedelmann to work independently on molecular architecture at surfaces and interfaces. For this purpose, he will learn various experimental techniques (Languir-Blodgett processes, GID) and be provided with the relevant (bio)chemical and crystallographical background. Dziedzina nauki natural sciencesbiological sciencesbiochemistrybiomoleculesnatural sciencesphysical sciencesopticsmicroscopyelectron microscopynatural sciencesphysical sciencesopticsspectroscopy Program(-y) FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998 Temat(-y) 0302 - Post-doctoral research training grants TC06 - Surface Science, Colloids & Heterogenous Catalysis Zaproszenie do składania wniosków Data not available System finansowania RGI - Research grants (individual fellowships) Koordynator WEIZMANN INSTITUTE OF SCIENCE Wkład UE Brak danych Adres Herzl street 2 76100 REHOVOT Izrael Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (1) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko Not available Niemcy Wkład UE Brak danych Adres Zobacz na mapie Koszt całkowity Brak danych