Objectif The DNA Damage Response (DDR) protects the genome from cytotoxic and mutagenic effects of chemicals and radiation in the environment. Genetic defects in DDR lead to genome instability and predispose individuals to diseases like cancer. DDR is a rapid, dynamic and integrated response to genome insult which co- ordinates cell cycle progression, DNA replication and DNA repair. Our understanding of DDR has been based largely on the use of specific approaches in specific model organisms: e.g. genetics in yeast, biochemistry in frogs, cytology in mammalian cells, etc. The participating teams are experts with these model organisms who are committed to expanding their repertoire of technical and conceptual approaches to studying DDR. Our objectives are:- To characterize mechanisms of genome surveillance in response to DNA damage and DNA replication stress by studying several key components (PI(3)- related kinases and associated subunits, Sgs1 helicasef PCNA and RF-C-related DDR components).- To examine the role of novel Components of the DNA damage signal transduction pathway.- To characterize the downstream effects of DDR on DNA replication, chromatin structure and ubiquit in mediated proteolysis. In each case, a multidisciplinary approach will involve the study of processes and proteins in different organisms using different technical strategies. This unique European collaboration will lead to new advances and contribute to an integrated view of DDR in eukaryotic cells. Champ scientifique natural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicinephysiologycytologynatural sciencesbiological sciencesgeneticsgenomes Programme(s) FP5-HUMAN POTENTIAL - Programme for research, technological development and demonstration on "Improving the human research potential and the socio-economic knowledge base" (1998-2002) Thème(s) 1.4.1.-1.1. - Research Training Networks Appel à propositions Data not available Régime de financement NET - Research network contracts Coordinateur CANCER RESEARCH UK Contribution de l’UE Aucune donnée Adresse Clare Hall Laboratories, Blanche Lane EN6 3LD POTTERS BAR Royaume-Uni Voir sur la carte Coût total Aucune donnée Participants (7) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire BEN GURION UNIVERSITY OF THE NEGEV Israël Contribution de l’UE Aucune donnée Adresse 84105 BEER SHEVA Voir sur la carte Coût total Aucune donnée CANCER RESEARCH UK Royaume-Uni Contribution de l’UE Aucune donnée Adresse Blanche Lane, Clare hall Laboratories EN6 3LD SOUTH MIMMS Voir sur la carte Coût total Aucune donnée ERASMUS UNIVERSITEIT ROTTERDAM Pays-Bas Contribution de l’UE Aucune donnée Adresse Dr. Molewaterplein 50 3000 DR ROTTERDAM Voir sur la carte Coût total Aucune donnée INSTITUT CURIE France Contribution de l’UE Aucune donnée Adresse Rue d' Ulm 26 75248 PARIS Voir sur la carte Coût total Aucune donnée UNIVERSITY OF GENEVA Suisse Contribution de l’UE Aucune donnée Adresse 30,Quai Ernest Ausermet 30 1211 GENEVE Voir sur la carte Coût total Aucune donnée UNIVERSITY OF SUSSEX Royaume-Uni Contribution de l’UE Aucune donnée Adresse Falmer BN1 9RR BRIGHTON / FALMER Voir sur la carte Coût total Aucune donnée UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA Italie Contribution de l’UE Aucune donnée Adresse Piazza della Scienza 2 20126 MILANO Voir sur la carte Coût total Aucune donnée
