Obiettivo Introduction of foreign nucleic acids into an organism induces frequently silencing of the homologous sequences. In some cases silencing is the result of a repression of transcription (transcriptional gene silencing or TGS). In other cases the silenced genes are transcribed but transcripts are nearly undetectable (post-transcriptional gene silencing or PIGS). Recent work has focused attention on double stranded RNA as a trigger for both TGS and PIGS (RNA silencing). So far RNA-mediated TGS has only been reported in plants, but PTGS-related phenomena have been described in plants, fungi and animals. Some results indicate that RNA silencing is a host defence system protecting organisms against parasitic sequences such as transposable elements and viruses. Given the importance of these sequences in the genomes, the elucidation of the mechanisms involved in their taming is a challenging question. One of the most exciting aspects of PIGS is that it seems that one common mechanism acts in diverse organisms, maybe in all eukaryotes, indicating that they are very important processes. The possibility that RNA-induced genome modifications (methylation, chromatin structure) are common to eukaryotes is still an open question, but the increasing detection of non-coding or antisense RNAs in epigenetic phenomena involving DNA or chromatin modifications (sex chromosome dosage compensation, imprinting) suggests widespread occurrence. The participants to this network have decided to join their efforts to elucidate by a combination of genetic and biochemical approaches the mechanisms underlying PTGS and RNA-mediated TGS in a variety of organisms (plants, fungi and animals), to determine the relationships between these two types silencing, the similarities and differences in the mechanisms of RNA silencing in various kingdoms and how they may be responsible for the protection of eukaryotes against the propagation of transposable elements and viruses. Campo scientifico natural sciencesbiological sciencesbiochemistrybiomoleculesnucleic acidsnatural sciencesbiological sciencesmicrobiologyvirologynatural sciencesbiological sciencesmicrobiologymycologynatural sciencesbiological sciencesgeneticsRNAnatural sciencesbiological sciencesgeneticsgenomes Programma(i) FP5-HUMAN POTENTIAL - Programme for research, technological development and demonstration on "Improving the human research potential and the socio-economic knowledge base" (1998-2002) Argomento(i) 1.4.1.-1.1. - Research Training Networks Invito a presentare proposte Data not available Meccanismo di finanziamento NET - Research network contracts Coordinatore CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Contributo UE Nessun dato Indirizzo Rue de la Cardonille 141 34396 MONTPELLIER Francia Mostra sulla mappa Costo totale Nessun dato Partecipanti (5) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto GMI - GREGOR-MENDEL-INSTITUT FUER MOLEKULARE PFLANZENBIOLOGIE GMBH Austria Contributo UE Nessun dato Indirizzo Dr Ignaz-Seipel-Platz 2 1010 WIEN Mostra sulla mappa Costo totale Nessun dato NETHERLANDS INSTITUTE FOR DEVELOPMENTAL BIOLOGY Paesi Bassi Contributo UE Nessun dato Indirizzo 8,Uppsalalaan 8 3584 CT UTRECHT Mostra sulla mappa Costo totale Nessun dato THE SAINSBURY LABORATORY Regno Unito Contributo UE Nessun dato Indirizzo Norwich Research Park, Colney Lane NR4 7UH NORWICH Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF EDINBURGH Regno Unito Contributo UE Nessun dato Indirizzo King's Building, Darwing Building, Mayfield Road EH9 3Jr EDINBURGH Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF ROME "LA SAPIENZA" Italia Contributo UE Nessun dato Indirizzo Viale Regina Elena 324 00161 Roma Mostra sulla mappa Costo totale Nessun dato