Cel The proposal describes how steps will be made to advance in the knowledge of is oprenoid biosynthesis in order to produce specific inhibitors that will be of use in the treatment of the leishamniases. Focus will be placed on the development of inhbitors against two enzymes: farnesyl diphosphate syntheses and squalling syntheses. Advantage will be taken of the existing knowledge on the inhibition of these enzymes in other organisms and of the crystal structures available for the modelling of the active site of the protozoan enzymes and identification of lead molecules. Alterations in is oprenoid composition, effects on parasite ultrustructural morphology and the intracellular localization of these enzymes will be studied in order to use the information in understanding drug toxicity, mode of action and intracellular transport requirements. Dziedzina nauki engineering and technologymaterials engineeringcrystalsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Program(-y) FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002" Temat(-y) Data not available Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Wkład UE Brak danych Adres Calle Ventanilla 11 18001 GRANADA Hiszpania Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (3) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko FEDERAL UNIVERSITY OF RIO DE JANEIRO Brazylia Wkład UE Brak danych Adres S/N,Edificio do Centro de Ciencias da Saude, Bloco G 21949-900 RIO DE JANEIRO Zobacz na mapie Koszt całkowity Brak danych INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTIFICAS Wenezuela Wkład UE Brak danych Adres KM 11,Altos de Pipe, KM. 11, Carretera Panamericana 1020 CARACAS Zobacz na mapie Koszt całkowity Brak danych UNIVERSITY OF WALES CARDIFF Zjednoczone Królestwo Wkład UE Brak danych Adres King Edward VII Avenue, Redwood Building CF10 3XF CARDIFF Zobacz na mapie Koszt całkowity Brak danych
