Cel It is now firmly established that antibodies can act as efficient catalysts. These catalytic antibodies (abzymes) are classically elicited by using transition state analogues as antigens. The Russian group participating in this project has pioneered an alternative idea, i.e. possible catalytic activity of anti-idiotypic antibodies, and has demonstrated the presence of natural catalytic autoantibodies in sera of patients with autoimmune diseases. On the other hand, the French group, also participating in this project, has demonstrated the possibility of eliciting catalytic anti-idiotypic antibodies as internal images of enzyme active sites used as antigens. This project, a joint investigation, is devoted to the search for new variants of natural catalytic antibodies and their comparison with corresponding analogues elicited by the anti-idiotypic approach. The project includes the study of general principles of antibody mediated catalysis and cloning of selected antibody genes in order to model and analyse the three-dimensional structures of their variable domains. Program(-y) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Temat(-y) 44 - Biotechnology Zaproszenie do składania wniosków Data not available System finansowania Data not available Koordynator Le Biopole Végétal Wkład UE Brak danych Adres 60206 Compiègne Francja Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (4) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko Istituto di Ricerche di Biologia Molecolare P. Angeletti SpA Włochy Wkład UE Brak danych Adres Via Pontina Km 30.6 00040 Pomezia Roma Zobacz na mapie Koszt całkowity Brak danych National Academy of Sciences of Ukraine Ukraina Wkład UE Brak danych Adres 252022 Kiev Zobacz na mapie Koszt całkowity Brak danych Russian Academy of Medical Sciences Rosja Wkład UE Brak danych Adres 115522 Moscow Zobacz na mapie Koszt całkowity Brak danych Russian Academy of Sciences Rosja Wkład UE Brak danych Adres 117984 Moscow Zobacz na mapie Koszt całkowity Brak danych
