Cel Following EEC directives on organotin-based antifoulants, hopes that the TBT problem may now be eradicated have not been entirely fulfilled: though levels of TBT in water have declined in many areas, steady state is approaching in some locations, occasionally exceeding water quality standards by more than two orders of magnitude. There are also concerns over the build-up and fate of TBT in sediments. Determinations of the present state of TBT contamination, trends in persistence and bioavailability and the assessment of risk for benthic organisms, in different climatic conditions (northern temperate to Mediterranean), form the core of this proposal. The focus will be on infaunal clams Ruditapes. decussata, Scrobicularia plana, bottom- dwelling fish e.g. Platichthys flesus, Mullus barbatus and neogastropods, Nucella lapillus, Nassarius reticulatus. TBT biovailability, metabolism and persistence in various components of sediment-based ecosystems will be quantified, accompanied by measurements of clam populations whose distributions are thought to have been influenced by TBT (confirmation of relative sensitivities of different life-stages to organotin will be sought). Comparisons will be made between areas where small boats are predominant (where existing legislation should be most effective) and those which are influenced by larger ships (still entitled to use TBT/TPT-based paints). Mesocosm studies will determine pathways of bioaccumulation, and how sediment conditions (physico-chemistry; granulometry; geological origin) influence partitioning, release, bioavailability and persistence. Molecular effects - on the mixed function oxidase (MFO) system, membrane damage, oxyradical generation, lipid peroxidation, mutagenicity and detoxification - will be determined with a view to development of novel markers of organotin exposure. The masculinizing effect of TBT on female gastropods is currently the most well-documented but the mechanisms underlying this response ('imposex') are poorly understood: experiments will test whether the gastropod MFO system is disturbed by TBT. Observations on imposex in British and Irish populations will be used to assess the effectiveness of legislation. Studies will be extended to important aquaculture centres in S. Europe as a means of predicting deleterious trends associated with the region's development. Dziedzina nauki agricultural sciencesagriculture, forestry, and fisheriesfisheriesnatural sciencesearth and related environmental scienceshydrologynatural sciencesbiological sciencesbiochemistrybiomoleculeslipidsnatural sciencesbiological sciencesecologyecosystems Program(-y) FP3-MAST 2 - Specific research and technological development programme (EEC) in the field of marine science and technology, 1990-1994 Temat(-y) 0304 - Studies on the exploitation of marine biological resources Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator NERC Centre of Coastal and Marine Sciences Wkład UE Brak danych Adres Prospect Place West Hoe PL1 3DH Plymouth Zjednoczone Królestwo Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (3) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Hiszpania Wkład UE Brak danych Adres 18-26,Jordi Girona 18-26 08034 BARCELONA Zobacz na mapie Koszt całkowity Brak danych UNIVERSIDADE DO ALGARVE Portugalia Wkład UE Brak danych Adres 322,Campus de Gambelas 8000 FARO Zobacz na mapie Koszt całkowity Brak danych University College Galway Irlandia Wkład UE Brak danych Adres 90 Galway Zobacz na mapie Koszt całkowity Brak danych