Cel This project will study basic inmunopathological mechanisms, including cellular and cytokine profiles, related to intraperitoneal immune granulomas seen in vaccinated farmed fish Atlantic salmon, rainbow trout and sea bass following the use of oil-adjuvant vaccines containing Aromas salmonicida, Vibrato angular or Pasteur Ella viscid. Emphasis on the contribution of eosinophilic granular cells/mast cells and of pro-inflammatory mediators and cytokines to granule formation. Techniques ranging from histocytoschemistry to gene expressions studies and ex vivo tissue explants will be used. Results contributing to the development of safer vaccine formulations for fish are expected.The project has shed light on the underlying mechanisms of granuloma formation in vaccinated farmed fish and it has been documented that the characteristics of the vaccine formulation, e.g. extracellular products, antigen content and stability has a bearing on the extent of injection site reactions. It has been shown that different cytokines are produced at the site of injection and that it is also up-regulated in immunocompetent organs like the spleen a few days after vaccination. Dziedzina nauki medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Program(-y) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Temat(-y) 1.1.1.-2. - Key action Control of Infectious Diseases Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator NORWEGIAN SCHOOL OF VETERINARY SCIENCE Wkład UE Brak danych Adres Ullevaalsveien 72 0033 OSLO Norwegia Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (4) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko ALPHARMA AS Norwegia Wkład UE Brak danych Adres Harbitzalleen 3 Skoyen 0212 OSLO Zobacz na mapie Koszt całkowity Brak danych ASSOCIACAO DO INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR Portugalia Wkład UE Brak danych Adres Rua de Campo Alegre, 823 4150 PORTO Zobacz na mapie Koszt całkowity Brak danych UNIVERSIDAD DE LEON Hiszpania Wkład UE Brak danych Adres AVENIDA DE LA FACULTAD 25 24071 LEON Zobacz na mapie Koszt całkowity Brak danych University of Aberdeen Zjednoczone Królestwo Wkład UE Brak danych Adres 2 Tillydrone Avenue AB9 2TN Aberdeen Zobacz na mapie Koszt całkowity Brak danych
