Ziel
The overall aim of this project is the development of multi-sequence DNA sensor arrays for the identification of multi-drug resistant (MDR) strains of Mycobacterium tuberculosis. The methodologies developed will allow assessment from clinical samples within hours, in comparison to the laborious and time-consuming methods presently in use. The use of a4 x 4 final configuration sensor arrays, allows for the development of a disposable, rapid, simple and one-step measurement system. Other potential product developed during the project will include a novel DNA release protocol from Mycobacterium, a PCR-Elsa based assay for assessment of clinical samples and a hand-held instrument for sensor array readout.
Wissenschaftliches Gebiet
- natural sciencesbiological sciencesgeneticsDNA
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensors
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemultidrug resistance
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance