Obiettivo The experimental approach and different levels of analysis is aimed at understanding the molecular and cellular early phases of the neurodegeneration in Alzheimer's disease. This is not possible in humans and requires animal models that allow invasive analysis. Transgenic mice expressing human AD related genes (APP, PS1, Ape) have been and continue to be generated and will be validated. They will extend and recapitulate new findings in less complex systems, implemented in this proposal. "Multiple" transgenic mouse strains with more than one human transgenic are expected to show more complete pathology. Most important aspect addressed will be fundamental aspects of amyloidogenesis relating to the role of Personalise and its path physiological sequels on cognition, behaviour, neuropathology, oxidative stress, calcium homeostasis, protein degradation and modifying proteins. Campo scientifico natural sciencesbiological scienceszoologymammalogyprimatologymedical and health sciencesbasic medicineneurologydementiaalzheimernatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicinepathologymedical and health sciencesbasic medicinephysiologyhomeostasis Programma(i) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Argomento(i) 1.1.1.-6. - Key action The Ageing Population and Disabilities Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore KATHOLIEKE UNIVERSITEIT LEUVEN Contributo UE Nessun dato Indirizzo Oude Markt 13 3000 LOUVAIN / LEUVEN Belgio Mostra sulla mappa Costo totale Nessun dato Partecipanti (3) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto 'NENCKI' INSTITUTE OF EXPERIMENTAL BIOLOGY - POLISH ACADEMY OF SCIENCES Polonia Contributo UE Nessun dato Indirizzo Pasteur Street 3 02 093 WARSZAWA Mostra sulla mappa Costo totale Nessun dato CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Francia Contributo UE Nessun dato Indirizzo Boulevard de l'Hôpital 83 CERVI 75013 PARIS Mostra sulla mappa Costo totale Nessun dato LUDWIG-MAXIMILIANS UNIVERSITY OF MUNICH Germania Contributo UE Nessun dato Indirizzo Geschwister-Scholl-Platz 1 80539 MUENCHEN Mostra sulla mappa Costo totale Nessun dato
