Objective Efficient and safe vectors for gene therapy of prostate and bladder cancer will be developed by modification of viruses with multivalent hydrophilic polymers. This approach is particularly powerful because it permits complete shielding of viral tropism without genetic engineering. The resulting vectors are less immunogenicthan normal viruses and will be targeted to tumour cell-surface receptors. Their infectivity of these vectors is not affected by neutralising antibodies in serum, a major limitation of current use of viruses for gene delivery - particularly in the clinics. Viruses retargeted in this way operate at a lower MOI than regular viruses in serum and maintain extremely high efficiency of gene expression. These vectors should provide an effective means to realise the substantial promise of gene therapy, and this proposal combines cell/molecular biology and virology with polymer chemistry in their development. Fields of science medical and health sciencesclinical medicineoncologyprostate cancermedical and health sciencesclinical medicineoncologybladder cancermedical and health sciencesmedical biotechnologygenetic engineeringgene therapynatural sciencesbiological sciencesmicrobiologyvirologynatural scienceschemical sciencespolymer sciences Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-6. - Key action The Ageing Population and Disabilities Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD EU contribution No data Address Woodstock Road OX2 6he OXFORD United Kingdom See on map Total cost No data Participants (2) Sort alphabetically Sort by EU Contribution Expand all Collapse all CANCER RESEARCH INSTITUTE Spain EU contribution No data Address Autovia Castelldefels Km 2,7 08907 HOSPITALET DEL LLOBREGAT See on map Total cost No data INSTITUTE OF MACROMOLECULAR CHEMISTRY - ACADEMY OF SCIENCES OF THE CZECH REPUBLIC Czechia EU contribution No data Address 2,Heyrovsky Sq. 2 162 06 PRAHA 6 See on map Total cost No data
