Objective
ApoAI and apoB-100 are important apolipoproteins involved in cholesterol transport. Our specific aims are:
1) To identify the DNA binding proteins which recognize regulatory regions of human apoAI and apoB-100 genes and to define the binding domains and properties of these proteins.
2) To purify and characterize the nuclear proteins involved in transcritional activation of human apoAI and ApoB-100 genes. 3) To clone and sequence cDNAs encoding the protein factors involved in the transcriptional regulation of human apoAI and apoB-100 genes. 4) To express the cDNA clones encoding the transcriptional factors in vitro and in vivo and define the domains involved in DNA binding and transcriptional activation.
Fields of science
Topic(s)
Data not availableCall for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
71110 IRAKLION
Greece