Modular Assembly of DNA-based systems; bio-inspired artificial allosteric assemblies

Project Information

MADNA

Grant agreement ID: 280010

Project closed

Start date 1 September 2011

End date 31 August 2016

Funded under

• Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Total cost € 1 430 003,00

EU contribution € 1 430 003,00

Coordinated by

RIJKSUNIVERSITEIT GRONINGEN
Netherlands

Objective

Artificial allosteric systems, i.e. (semi-)synthetic systems that give an autonomous response to changes in their environment, are of great interest for applications as sensors, drug delivery and drug targeting.

The overall aim of this proposal is the development of bio-inspired DNA-based artificial allosteric systems that are of interest for biological and bio-medical applications.

In the present proposal, DNA will be used as the general scaffold for the design and construction of artificial allosteric systems and DNA-strand exchange will be used as a key mechanism to affect a predictable structural change in the system, resulting in a measurable response. Structure switching aptamers will be used to make this response small molecule dependent.

Fields of science

• natural sciences › biological sciences › genetics › DNA
• engineering and technology › electrical engineering, electronic engineering, information engineering › electronic engineering › sensors

Programme(s)

• FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Topic(s)

• ERC-SG-PE5 - ERC Starting Grant - Materials and Synthesis

Call for proposal

ERC-2011-StG_20101014
See other projects for this call

Funding Scheme

ERC-SG - ERC Starting Grant

Host institution

RIJKSUNIVERSITEIT GRONINGEN

• EU contribution: € 1 430 003,00
• Address: Broerstraat 5 ; 9712CP Groningen ; Netherlands
• Region: Noord-Nederland › Groningen › Overig Groningen
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: H.D. Veldhuis (Dr.)
• Principal investigator: Johannes Gerhardus Roelfes (Dr.)
• Total cost: No data

Beneficiaries (1)

RIJKSUNIVERSITEIT GRONINGEN

Netherlands

• EU contribution: € 1 430 003,00
• Address: Broerstraat 5 ; 9712CP Groningen
• Region: Noord-Nederland › Groningen › Overig Groningen
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: H.D. Veldhuis (Dr.)
• Principal investigator: Johannes Gerhardus Roelfes (Dr.)
• Total cost: No data