Artificial allosteric systems, i.e. (semi-)synthetic systems that give an autonomous response to changes in their environment, are of great interest for applications as sensors, drug delivery and drug targeting.
The overall aim of this proposal is the development of bio-inspired DNA-based artificial allosteric systems that are of interest for biological and bio-medical applications.
In the present proposal, DNA will be used as the general scaffold for the design and construction of artificial allosteric systems and DNA-strand exchange will be used as a key mechanism to affect a predictable structural change in the system, resulting in a measurable response. Structure switching aptamers will be used to make this response small molecule dependent.
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