Obiettivo This project aims to create new-to-nature and tailor-made biosurfactants through metabolic engineering of the unconventional yeast Candida bombicola. Biosurfactants produced by fermentation offer a worthy alternative to traditional surfactants, which are typically derived from non-renewable petrochemical resources and may cause environmental problems due to their ecotoxicity and poor biodegradability. Despite the clear advantages of biosurfactants, their overall use is hampered by the lack of structural variation. This is in sharp contrast to chemically produced surfactants where one can introduce variation by simply changing the building blocks. Structural variation is essential as (bio)surfactants find application in a very broad range of sectors. This project aims to alleviate this fundamental limitation by developing a generic biotechnological production technology for glycolipid biosurfactants. This will in turn significantly broaden the range of commercial biosurfactants, satisfying the need for structural diversity in the market. It is expected that this technology will result in a breakthrough penetration of glycolipid biosurfactants in the overall surfactant market, in this way helping to build the bio-based economy.Indeed, biosurfactants are a promising target for the biobased economy as the world surfactant production exceeds 13 Mton/year and is meanly based on petrochemical raw materials.The very efficient biosurfactant producing yeast C. bombicola will be metabolically engineered such that all structural parts of the glycolipid biosurfactant molecule can be controlled: fatty acid tail, sugar moiety, acetylation and lactonization. New technology for metabolic engineering of unconventional organisms such as the use of meganucleases will be developed and strains will be evaluated by several “omics” approaches: proteomics, transcriptomics and metabolomics . Metabolically engineered production strains equipped with new combinations of genes and pathways will synthesize tailor-made and new-to-nature biosurfactants. For each target molecule, a fermentation process will be developed and the molecules will be evaluated for various applications (cleaning and cosmetics, medics and nanoscience). The project thus covers the whole innovation chain from basic research to production and application development. To achieve this goal, a complementary consortium of European academic and industrial partners (including a large participation of SMEs) has been formed that covers the whole range of required expertises.In brief, BIOSURFING promotes the use of biotechnology as a valid production process for novel industrial compounds, the development of biotechnological platform technologies and robust microbial industrial production systems. Moreover, the projects helps to realise the objectives of EU environmental and innovation policy initiatives, such as the Environmental Technology Action Plan and the EU Strategy for key enabling technologies. Campo scientifico engineering and technologyindustrial biotechnologymetabolic engineeringnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural sciencesbiological sciencesbiochemistrybiomoleculeslipidssocial scienceseconomics and businesseconomicsbioeconomyengineering and technologyindustrial biotechnologybioprocessing technologiesfermentation Programma(i) FP7-KBBE - Specific Programme "Cooperation": Food, Agriculture and Biotechnology Argomento(i) KBBE.2011.3.3-03 - Cellular, metabolic and genetic engineering for novel compounds Invito a presentare proposte FP7-KBBE-2011-5 Vedi altri progetti per questo bando Meccanismo di finanziamento CP-TP - Collaborative Project targeted to a special group (such as SMEs) Coordinatore UNIVERSITEIT GENT Contributo UE € 1 107 758,00 Indirizzo SINT PIETERSNIEUWSTRAAT 25 9000 Gent Belgio Mostra sulla mappa Regione Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Wim Soetaert (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (7) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto CELLECTIS SA Francia Contributo UE € 296 150,00 Indirizzo RUE JEAN ANTOINE DE BAIF 12 75013 PARIS Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo David J.D. Sourdive (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITY OF ULSTER Regno Unito Contributo UE € 376 798,00 Indirizzo CROMORE ROAD BT52 1SA Coleraine Mostra sulla mappa Regione Northern Ireland Northern Ireland Causeway Coast and Glens Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Anne Marie Patton (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato BIO BASE EUROPE PILOT PLANT VZW Belgio Contributo UE € 692 684,00 Indirizzo RODENHUIZEKAAI 1 9042 Desteldonk Gent Mostra sulla mappa Regione Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Tipo di attività Other Contatto amministrativo Vindevogel Sofia (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato WERNER & MERTZ GMBH Germania Contributo UE € 56 945,00 Indirizzo RHEINALLEE 96 55120 MAINZ Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Rebekka Völp (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato TSATSOS GEORGIOS Grecia Contributo UE € 74 120,00 Indirizzo IOANNOU METAXA 56 19400 Koropi Mostra sulla mappa Regione Αττική Aττική Ανατολική Αττική Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Georgios Tsatsos (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato ECOVER CO-ORDINATION CENTER Belgio Contributo UE € 50 118,00 Indirizzo INDUSTRIEWEG 3 2390 Malle Mostra sulla mappa Regione Vlaams Gewest Prov. Antwerpen Arr. Antwerpen Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Elke Theeuwes (Mrs.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6 Francia Contributo UE € 316 040,00 Indirizzo Place Jussieu 4 75252 PARIS Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Ouerdia Oumohand (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato