Objective
A novel analytical platform is proposed to detect and identify DNA at low concentration in a high throughput manner at the single molecule level.
The potential impact of this research is significant and will result in single molecule detection becoming a mainstream tool within the medical diagnostics and analytical communities. 'Rare event' detection plays an important role in the early detection of illnesses and disease (e.g. cancers and bacterial infections). Using analytical technologies that exist today it is almost impossible to detect a single DNA strand within a standard blood sample (of a few mLs) within a reasonable time frame. The technology that will be developed within the current project will allow for such detection to be performed both rapidly and efficiently. If successful, the core technology described will become a mainstream analytical tool that will be of significant benefit within biomedical laboratories, hospitals, and clinics around the world.
Specifically, chemical and semiconductor processing methods will be developed to define a novel approach to high throughput DNA quantification at the single molecule level. This innovative technology will function by introducing biological samples in micro- and nanofluidic chips and using electric fields to direct DNA strands through nanometre-sized pores on a membrane. Detection and sizing of the individual DNA strands (labelled with fluorophores) is then accomplished using confocal fluorescence spectroscopy.
This new approach to high-throughput, single molecule DNA analysis harnesses the strengths of both analytical spectroscopy and silicon fabrication technology to allow the creation of hybrid devices in which molecular quantification can be realized. I expect this work to have major impact and open up new possibilities for nano-analytical tools in the chemical and biological sciences.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences genetics DNA
- natural sciences physical sciences optics spectroscopy emission spectroscopy
- medical and health sciences clinical medicine oncology
- natural sciences physical sciences electromagnetism and electronics semiconductivity
- natural sciences chemical sciences inorganic chemistry metalloids
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2011-StG_20101014
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
SW7 2AZ LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.