Objective
In hematopoiesis, failure to maintain homeostasis and regenerative functions result in a multitude of hematological malignancies, including myelodysplastic syndromes, lymphomas and leukemias, that represent a medical challenge and a large socioeconomic burden because of the large number of affected patients of all age groups. Although hierarchical organization of the hematopoietic system has been well defined in the last years, the precise molecular circuits governing the balance between proliferation/commitment/specification and how these are corrupted in disease are largely unknown.
The focus of Hem-ID is a highly integrated approach to study the functional interactions between the genetic regulatory circuits orchestrated by transcription factors –TFs-, (that direct the progressive cell type specification) and epigenetic mechanisms (that establish the “cellular memory” that fixes cell fate decisions during differentiation) in physiological hematopoiesis and in leukemia with the final goal of formulating novel diagnostic/prognostic markers and therapeutic approaches in treating leukemias. HEM_ID will:
-Decipher Modular Networks assembled by master TFs controlling hematopoietic self renewal and differentiation and the molecular dynamics of TFs/DNA interactions by unique biophysical approache
-Identify epigenetic modifiers (new relevant loci, -epiQTLs, DNAmethylation, Polycomb dependent-gene silencing, miRNA and long non coding RNAs) involved in the pathogenesis of leukemias.
The strength of Hem-ID ITN lies in the high quality multidisciplinary -but strictly integrated- expertise and technological platforms covering the complete pathway from basic research to its clinical exploitation- contributed from both public Institutions and Private sector and made available to Hem-ID Fellows. Besides research, an integrated training program of scientific and complementary activities will be offered to HEM-ID Fellows that will complement and strengthen their career development.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences genetics RNA
- medical and health sciences clinical medicine oncology leukemia
- medical and health sciences basic medicine physiology homeostasis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-ITN
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
20126 Milano
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.