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HEMatopoietic cell IDentity : genetic and epigenetic regulation in normal and malignant hematopoiesis

Objective

In hematopoiesis, failure to maintain homeostasis and regenerative functions result in a multitude of hematological malignancies, including myelodysplastic syndromes, lymphomas and leukemias, that represent a medical challenge and a large socioeconomic burden because of the large number of affected patients of all age groups. Although hierarchical organization of the hematopoietic system has been well defined in the last years, the precise molecular circuits governing the balance between proliferation/commitment/specification and how these are corrupted in disease are largely unknown.
The focus of Hem-ID is a highly integrated approach to study the functional interactions between the genetic regulatory circuits orchestrated by transcription factors –TFs-, (that direct the progressive cell type specification) and epigenetic mechanisms (that establish the “cellular memory” that fixes cell fate decisions during differentiation) in physiological hematopoiesis and in leukemia with the final goal of formulating novel diagnostic/prognostic markers and therapeutic approaches in treating leukemias. HEM_ID will:
-Decipher Modular Networks assembled by master TFs controlling hematopoietic self renewal and differentiation and the molecular dynamics of TFs/DNA interactions by unique biophysical approache
-Identify epigenetic modifiers (new relevant loci, -epiQTLs, DNAmethylation, Polycomb dependent-gene silencing, miRNA and long non coding RNAs) involved in the pathogenesis of leukemias.
The strength of Hem-ID ITN lies in the high quality multidisciplinary -but strictly integrated- expertise and technological platforms covering the complete pathway from basic research to its clinical exploitation- contributed from both public Institutions and Private sector and made available to Hem-ID Fellows. Besides research, an integrated training program of scientific and complementary activities will be offered to HEM-ID Fellows that will complement and strengthen their career development.

Call for proposal

FP7-PEOPLE-2011-ITN
See other projects for this call

Funding Scheme

MC-ITN - Networks for Initial Training (ITN)

Coordinator

UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA
Address
Piazza Dell'ateneo Nuovo 1
20126 Milano
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 438 385
Administrative Contact
Anastasia Sguera (Dr.)

Participants (11)

CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH
Austria
EU contribution
€ 255 444
Address
Lazarettgasse 14 Akh Bt 25.3
1090 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Giulio Superti-Furga (Prof.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 264 653,01
Address
Rue Michel Ange 3
75794 Paris
Activity type
Other
Administrative Contact
Sandrine Magnetto (Dr.)
UNIVERSITE JOSEPH FOURIER GRENOBLE 1
France
EU contribution
€ 264 653,01
Address
Avenue Centrale, Domaine Universitaire 621
38041 Grenoble
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sophie Beaubron (Ms.)
BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING
Greece
EU contribution
€ 219 407
Address
Fleming Street 34
16672 Vari-athens
Activity type
Research Organisations
Administrative Contact
Charalambos Savakis (Dr.)
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 238 763
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
Administrative Contact
Eusebio Jimènez Arroyo (Mr.)
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 259 231
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gerald De Haan (Prof.)
INSTITUT CURIE
France
EU contribution
€ 270 184,01
Address
Rue D'ulm 26
75231 Paris
Activity type
Research Organisations
Administrative Contact
Corinne Cumin (Ms.)
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
France
EU contribution
€ 269 493,01
Address
Rue Laurent Fries 1
67404 Illkirch Graffenstaden
Activity type
Research Organisations
Administrative Contact
Brooks Steve (Dr.)
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Italy
EU contribution
€ 256 445
Address
Piazzale Aldo Moro 5
00185 Roma
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alessandro Fatica (Dr.)
Source Bioscience plc
United Kingdom
EU contribution
€ 271 759,01
Address
Orchard Place, Business Park 1
NG8 6PX Nottingham
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Robert Bakewell (Mr.)
NERVIANO MEDICAL SCIENCES S.R.L
Italy
EU contribution
€ 261 285
Address
Viale Luigi Pasteur 10
20014 Nerviano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Fabio Gasparri (Dr.)