Objective The ST-FLOW Project merges the efforts of 14 leading European research groups for developing material and computational standards that enable the forward-design of prokaryotic systems with a degree of robustness and predictability that is not possible with customary Genetic Engineering. The central issue at stake is the identification and implementation of rules that allow the conversion of given biological parts assembled with a set of principles for physical composition into perfectly predictable functional properties of the resulting devices, modules and entire systems. ST-FLOW focuses on each of the steps that go from assembling a DNA sequence encoding all necessary expression signals in a prokaryotic host (by default, E. coli) all the way to the making of the final product or to the behaviour of single cells and populations. Two complementary approaches will be adopted to solve the conundrum of physical composition vs. biological functionality of thereby engineered devices. In one case (bottom up), large combinatorial libraries of gene expression signals will be merged with suitable reporter systems and the input/output functions examined and parameterized in a high-throughput fashion. The expected outcome of this effort is to establish experience-based but still reliable rules and criteria for the assembly of new devices and systems -following the same physical composition rules or adopting CAD design. Yet, many outliers (combinations that do not follow the rules) are expected, and making sense of them will be the task of the complementary top-down approach. In this case, ST-FLOW will revisit some of gaps in our knowledge of the gene expression flow (transcription, mRNA fate, translation) that need to be addressed for engineering functional devices from first principles. Ethical, legal and societal issues will also be examined in a context of public dialogue and sound science communication. Fields of science natural sciencesbiological sciencesgeneticsDNAmedical and health sciencesmedical biotechnologygenetic engineering Programme(s) FP7-KBBE - Specific Programme "Cooperation": Food, Agriculture and Biotechnology Topic(s) KBBE.2011.3.6-03 - Towards standardisation in Synthetic Biology Call for proposal FP7-KBBE-2011-5 See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS EU contribution € 1 145 874,00 Address CALLE SERRANO 117 28006 Madrid Spain See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact Alberto Sereno álvarez (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (14) Sort alphabetically Sort by EU Contribution Expand all Collapse all IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE United Kingdom EU contribution € 992 248,00 Address SOUTH KENSINGTON CAMPUS EXHIBITION ROAD SW7 2AZ LONDON See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Shaun Power (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Switzerland EU contribution € 982 722,00 Address Raemistrasse 101 8092 Zuerich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Administrative Contact Sven Panke (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE UNIVERSITY OF BIRMINGHAM United Kingdom EU contribution € 383 922,00 Address Edgbaston B15 2TT Birmingham See on map Region West Midlands (England) West Midlands Birmingham Activity type Higher or Secondary Education Establishments Administrative Contact May Chung (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUTO DE TECNOLOGIA QUIMICA E BIOLOGICA - UNIVERSIDADE NOVA DE LISBOA Portugal EU contribution € 281 730,00 Address Avenida da Republica, Estacao Agronomica Nacional 2784-505 OEIRAS See on map Activity type Higher or Secondary Education Establishments Administrative Contact Maria De Lurdes Conceicao (Dr.) Links Contact the organisation Opens in new window Total cost No data CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France EU contribution € 340 800,00 Address RUE MICHEL ANGE 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Adrien Nusca (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data LIFEWIZZ LDA Participation ended Portugal EU contribution No data Address Rua Pero de Alenquer 123/7E 4150 616 PORTO See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Vitor Martins Dos Santos (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITE DE LAUSANNE Switzerland EU contribution € 335 520,00 Address QUARTIER UNIL CENTRE - BATIMENT UNICENTRE 1015 LAUSANNE See on map Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Higher or Secondary Education Establishments Administrative Contact Jan Roelof Van Der Meer (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BIOILIBERIS RESEARCH AND DEVELOPMENT SL Spain EU contribution € 205 200,00 Address AV DE LA INNOVACION 1 PARQUE TECNOLOGICO DE CIENCIAS SALUD 18100 ARMILLA GRANADA See on map Region Sur Andalucía Granada Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Matilde Fernández (Dr.) Links Contact the organisation Opens in new window Total cost No data UNIVERSITY OF STUTTGART Germany EU contribution € 307 584,00 Address KEPLERSTRASSE 7 70174 Stuttgart See on map Region Baden-Württemberg Stuttgart Stuttgart, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Ralf Takors (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAT DE VALENCIA Spain EU contribution € 341 315,00 Address AVENIDA BLASCO IBANEZ 13 46010 Valencia See on map Region Este Comunitat Valenciana Valencia/València Activity type Higher or Secondary Education Establishments Administrative Contact Angeles Sanchis (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BIOFACTION KG Austria EU contribution € 244 926,00 Address KUNDMANNGASSE 39/12 1030 Wien See on map Region Ostösterreich Wien Wien Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Markus Schmidt (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TECHNISCHE UNIVERSITAET MUENCHEN Germany EU contribution € 67 200,00 Address Arcisstrasse 21 80333 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Katrin Hörmann (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE UNIVERSITY OF EDINBURGH United Kingdom EU contribution € 87 969,00 Address OLD COLLEGE, SOUTH BRIDGE EH8 9YL Edinburgh See on map Region Scotland Eastern Scotland Edinburgh Activity type Higher or Secondary Education Establishments Administrative Contact Nisha Patel (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Isthmus France EU contribution € 281 732,00 Address Rue Saint Amand 31 75015 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Pierre Dedenys (Mr.) Links Contact the organisation Opens in new window Total cost No data
