Objective
The aim of this research is to develop cardiovascular (CV) fluid mechanics tools that can analyze and predict the vascular changes due to the growth and remodeling process (GR) during early embryonic cardiac development. Mechanical flow-induced loading, in addition to the genetic factors, is an essential regulator of the GR feedback process. Fluid-induced vascular network changes will be computed through transformative aims at the system level; that are coupled to the lower-level GR theories. The rich diversity of circulation systems found in nature inspired a novel reduced-order lumped parameter circulation model (LPM). For the first-time, LPM is integrated with multi-scale continuum mechanics vascular GR theories in order to establish a numerical feed-back loop between the GR response and instantaneous hemodynamic circuit parameters. A general network-based LPM model is proposed, again for the first time that covers the entire hydrodynamic network space where the numbers of vascular compartments, ventricles and their branching patterns evolve freely, but are subject to the cost functions founded on the biological optimality principles. Novel circuit similitude parameters that allow an unbiased energetic comparison will be developed. This framework will provide the global GR response of the entire circulation during development, energy/exergy budgets of complex congenital heart disease pathologies, and impact pediatric surgical treatments. At the organ level, The advanced boundary condition routines developed will transform the broader patient-specific CFD technology, which is currently used in clinical decision making. This project will have an impact on the pediatric and fetal cardiology, and CV surgery by giving researchers access to quantitative physiological information. Embryonic CV fluid dynamics is an emerging research field that challenges the human-centric bias and apathetic viewpoint of the static mature and healthy CV system at all educational levels.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine surgery
- medical and health sciences clinical medicine cardiology paediatric cardiology
- natural sciences physical sciences classical mechanics fluid mechanics fluid dynamics
- medical and health sciences basic medicine pathology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
34450 Istanbul
Türkiye
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.