Objective The aim of this research is to develop cardiovascular (CV) fluid mechanics tools that can analyze and predict the vascular changes due to the growth and remodeling process (GR) during early embryonic cardiac development. Mechanical flow-induced loading, in addition to the genetic factors, is an essential regulator of the GR feedback process. Fluid-induced vascular network changes will be computed through transformative aims at the system level; that are coupled to the lower-level GR theories. The rich diversity of circulation systems found in nature inspired a novel reduced-order lumped parameter circulation model (LPM). For the first-time, LPM is integrated with multi-scale continuum mechanics vascular GR theories in order to establish a numerical feed-back loop between the GR response and instantaneous hemodynamic circuit parameters. A general network-based LPM model is proposed, again for the first time that covers the entire hydrodynamic network space where the numbers of vascular compartments, ventricles and their branching patterns evolve freely, but are subject to the cost functions founded on the biological optimality principles. Novel circuit similitude parameters that allow an unbiased energetic comparison will be developed. This framework will provide the global GR response of the entire circulation during development, energy/exergy budgets of complex congenital heart disease pathologies, and impact pediatric surgical treatments. At the organ level, The advanced boundary condition routines developed will transform the broader patient-specific CFD technology, which is currently used in clinical decision making. This project will have an impact on the pediatric and fetal cardiology, and CV surgery by giving researchers access to quantitative physiological information. Embryonic CV fluid dynamics is an emerging research field that challenges the human-centric bias and apathetic viewpoint of the static mature and healthy CV system at all educational levels. Fields of science medical and health sciencesclinical medicinesurgerymedical and health sciencesclinical medicinecardiologypaediatric cardiologynatural sciencesphysical sciencesclassical mechanicsfluid mechanicsfluid dynamicsmedical and health sciencesbasic medicinepathology Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2011-CIG - Marie-Curie Action: "Career Integration Grants" Call for proposal FP7-PEOPLE-2011-CIG See other projects for this call Funding Scheme MC-CIG - Support for training and career development of researcher (CIG) Coordinator KOC UNIVERSITY Address Rumeli feneri yolu sariyer 34450 Istanbul Türkiye See on map Region İstanbul İstanbul İstanbul Activity type Higher or Secondary Education Establishments Administrative Contact Askim Demiryurek (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data
