Objective
The epicardium is a mesothelial tissue that plays a crucial role during heart development, by contributing to the formation of cardiovascular precursor cells and by producing growth factors important for heart formation. Wt1 gene encodes a zinc finger protein, which plays a critical role in normal development of several organs such as kidney, gonads, spleen and heart. During heart formation, Wt1 is mainly expressed in the epicardium and epicardial derived cells. Deletion of Wt1 gene in an epicardial specific manner lead to a KO mouse with profound defect in both cardiomyocyte proliferation and coronary vascular development, suggesting that Wt1 KO epicardial cells constitute a good model to study the putative growth factors and signalling produced by epicardial cells. The principal objectives of the proposed project are to identify new targets of Wt1 during cardiovascular development, to explore their role in the formation of coronary blood vessels and cardiomyocyte proliferation and to dissect some of the mechanisms involved. We propose to study how Wt1 deletion, in vitro and in vivo, induced expression or repression of chemokines and growth factors and how this influences heart morphogenesis. The molecular mechanisms that regulate the development of the cardiovascular system in mouse embryos are comparable with those that regulate repair in adult tissue. The identification of new Wt1 targets during epicardium development, would allow us to design new strategies to activate those pathways during regeneration and repair of damaged hearts
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry transition metals
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine embryology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
08007 BARCELONA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.