Using chemical-biology to synthesis and study nuclear receptor proteins

Project Information

CHEMbioNMR

Grant agreement ID: 298489

Project closed

Start date 1 April 2012

End date 31 March 2014

Funded under

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Total cost € 183 805,80

EU contribution € 183 805,80

Coordinated by

TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands

Objective

The rapidly growing field of Chemical Biology combines the power of synthetic chemistry with the spectrum of micro- and molecular biology techniques, thus important challenges in medicine can be addressed in revolutionary new ways. This innovative methodology allows problems associated with studying diseases and designing novel drug-like molecules to be tackled in a unique approach. A recent example is the combination of synthetic carbohydrate chemistry with parasite glycobiology that has led to a new candidate for a malaria vaccine. Besides infectious diseases, cancer is a major cause of death worldwide and in Europe 2.4 million cases of cancer are reported per year, 50% of which are fatal.

In this proposal we present a chemical biology route to propel research in cancer biology forward so that new drug targets can be identified. This global aim will be achieved by using a multidisciplinary approach, which employs peptide synthesis, molecular biology, NMR spectroscopy, X-ray crystallography and other cutting-edge biophysical techniques.
This project, which aims to synthesize different ER modified constructs for elucidating comprehensively the role of post-translational modifications in the development of breast cancer and resistance to tamoxifen, would be of high importance for advancing prevention, early detection, monitoring and treatment of the breast cancer disease.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.

• medical and health sciences › health sciences › infectious diseases › malaria
• medical and health sciences › clinical medicine › oncology › breast cancer
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › vaccines
• natural sciences › physical sciences › optics › spectroscopy › absorption spectroscopy
• natural sciences › biological sciences › molecular biology

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Programme(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Topic(s)

• FP7-PEOPLE-2011-IEF - Marie-Curie Action: "Intra-European fellowships for career development"

Call for proposal

FP7-PEOPLE-2011-IEF
See other projects for this call

Funding Scheme

MC-IEF - Intra-European Fellowships (IEF)

Coordinator

TECHNISCHE UNIVERSITEIT EINDHOVEN

• EU contribution: € 183 805,80
• Address: GROENE LOPER 3 ; 5612 AE Eindhoven ; Netherlands
• Region: Zuid-Nederland › Noord-Brabant › Zuidoost-Noord-Brabant
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data