The rapidly growing field of Chemical Biology combines the power of synthetic chemistry with the spectrum of micro- and molecular biology techniques, thus important challenges in medicine can be addressed in revolutionary new ways. This innovative methodology allows problems associated with studying diseases and designing novel drug-like molecules to be tackled in a unique approach. A recent example is the combination of synthetic carbohydrate chemistry with parasite glycobiology that has led to a new candidate for a malaria vaccine. Besides infectious diseases, cancer is a major cause of death worldwide and in Europe 2.4 million cases of cancer are reported per year, 50% of which are fatal.
In this proposal we present a chemical biology route to propel research in cancer biology forward so that new drug targets can be identified. This global aim will be achieved by using a multidisciplinary approach, which employs peptide synthesis, molecular biology, NMR spectroscopy, X-ray crystallography and other cutting-edge biophysical techniques.
This project, which aims to synthesize different ER modified constructs for elucidating comprehensively the role of post-translational modifications in the development of breast cancer and resistance to tamoxifen, would be of high importance for advancing prevention, early detection, monitoring and treatment of the breast cancer disease.
Fields of science
Call for proposal
See other projects for this call