Objective
Ischemic heart disease (IHD) is the most common cause of death in the Western world, accounting for more than 741.000 deaths each year in the European Union with yearly costs in excess of € 45 billion. Myocardial infarction (heart attack; MI) captures a significant segment of IHD population and is associated with sudden death as well significant morbidity and mortality. Currently the only cure for end-stage heart failure is cardiac transplantation. As cardiac donors are scarce, there is an urgent need to develop new strategies for regeneration. One experimental approach to treat defected organs is tissue engineering. Engineered cardiac patches to replace scar tissue after MI are produced by seeding cardiac cells within 3D biomaterials. However, success of this approach can be jeopardized by a lack of supporting microenvironment for the organization of a thick tissue and lack of electrical conductivity within the construct, both leading to impaired electrical signal propagation. Another limitation is the lack of an appropriate cell source. In the current proposal we first aim to engineer a 3D microenvironment mimicking the natural ECM of the myocardium. This synthetic matrix will be embedded with gold nanowires to increase electrical signal propagation between cardiac cell bundles. In the second step the ability of this unique microenvironment to support the culture and organization of human cardiac stem cells to a functional mature tissue will be explored. Finally, we will investigate the potential of the nanowired cardiac patch to improve the infarcted heart function. The proposed study has a potential to present a breakthrough in tissue engineering, and could help develop conductive cardiac patches to replace scar tissue after MI and repair congenital heart diseases. Moreover, the approach proposed here could even allow an entirely new strategy to repairing damaged cardiac conduction systems.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine cardiology paediatric cardiology
- medical and health sciences medical biotechnology tissue engineering
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- medical and health sciences clinical medicine transplantation
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
69978 Tel Aviv
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.