Mucus Permeating Nanoparticulate Drug Delivery Systems

Project Information

ALEXANDER

Grant agreement ID: 280761

Project closed

Start date 1 April 2012

End date 31 March 2016

Funded under

• Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies

Total cost € 11 147 592,65

EU contribution € 8 098 202,00

Coordinated by

DECHEMA GESELLSCHAFT FUR CHEMISCHETECHNIK UND BIOTECHNOLOGIE
Germany

Objective

The objective of the ALEXANDER project is the identification of novel strategies (e.g. proteolytic enzyme strategy, thiomer strategy, zeta potential changing systems, SNEDDS strategy) and the optimization of existing strategies (e.g. disulfide breaking strategy and slippery surface strategy) for the efficient transport of nanocarriers through the mucus gel layer (e.g. intestinal, nasal, ocular, vaginal, buccal, pulmonary). In particular, R&D activities will be focused on the synthesis of functionalized nanocarriers capable of permeating the mucus gel layer and delivering their therapeutic payload to the epithelium. The nanocarriers will be characterized with respect to their physicochemical properties, ability to cross the mucus gel layer, in vitro and in vivo cytotoxicity. The potential of the developed nanocarriers as delivery systems for mucosal administration of macromolecules will be demonstrated via the oral delivery of peptides, oligosaccharides and oligonucleotides and the nasal delivery of a plasmid encoding for an antigen.

Fields of science

• natural sciences › biological sciences › biochemistry › biomolecules › proteins › enzymes

Programme(s)

• FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies

Topic(s)

• NMP.2011.1.2-2 - New targeted therapy using nanotechnology for transport of macro-molecules across biological barriers

Call for proposal

FP7-NMP-2011-LARGE-5
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

DECHEMA GESELLSCHAFT FUR CHEMISCHETECHNIK UND BIOTECHNOLOGIE

• EU contribution: € 1 015 908,63
• Address: THEODOR HEUSS ALLEE 25 ; 60486 Frankfurt ; Germany
• Region: Hessen › Darmstadt › Frankfurt am Main, Kreisfreie Stadt
• Activity type: Research Organisations
• Administrative Contact: Andreas Förster (Dr.)
• Total cost: No data

Participants (18)

UNIVERSITAET INNSBRUCK

Austria

• EU contribution: € 692 998,80
• Address: INNRAIN 52 ; 6020 Innsbruck
• Region: Westösterreich › Tirol › Innsbruck
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Andreas Bernkop-Schnuerch (Prof.)
• Total cost: No data

ARISTOTELIO PANEPISTIMIO THESSALONIKIS

Greece

• EU contribution: € 580 744,40
• Address: KEDEA BUILDING, TRITIS SEPTEMVRIOU, ARISTOTLE UNIVERSITY CAMPUS ; 546 36 THESSALONIKI
• Region: Βόρεια Ελλάδα › Κεντρική Μακεδονία › Θεσσαλονίκη
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Georgia Petridou (Ms.)
• Total cost: No data

UNIVERSITY OF NEWCASTLE UPON TYNE

United Kingdom

• EU contribution: € 633 211,20
• Address: KINGS GATE ; NE1 7RU Newcastle Upon Tyne
• Region: North East (England) › Northumberland and Tyne and Wear › Tyneside
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Aleona Blinova (Ms.)
• Total cost: No data

CARDIFF UNIVERSITY

United Kingdom

• EU contribution: € 288 002,90
• Address: NEWPORT ROAD 30 36 ; CF24 0DE Cardiff
• Region: Wales › East Wales › Cardiff and Vale of Glamorgan
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Nick Bodycombe (Mr.)
• Total cost: No data

UNIVERSIDAD DE NAVARRA

Spain

• EU contribution: € 728 634,80
• Address: CAMPUS UNIVERSITARIO EDIFICIO CENTRAL ; 31080 Pamplona
• Region: Noreste › Comunidad Foral de Navarra › Navarra
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Iñigo Uriarte Pueyo (Dr.)
• Total cost: No data

INSTITUT JOZEF STEFAN

Slovenia

• EU contribution: € 565 000,00
• Address: Jamova 39 ; 1000 Ljubljana
• Region: Slovenija › Zahodna Slovenija › Osrednjeslovenska
• Activity type: Research Organisations
• Administrative Contact: Jadran Lenarcic (Prof.)
• Total cost: No data

EVONIK INDUSTRIES AG

Participation ended

Germany

• EU contribution: € 376 949,50
• Address: RELLINGHAUSER STRASSE 1-11 ; 45128 Essen
• Region: Nordrhein-Westfalen › Düsseldorf › Essen, Kreisfreie Stadt
• Administrative Contact: Rosario Lizio (Dr.)
• Total cost: No data

LEK FARMACEVTSKA DRUZBA DD

Slovenia

• EU contribution: € 343 997,00
• Address: VEROVSKOVA ULICA 57 ; 1526 LJUBLJANA
• Region: Slovenija › Zahodna Slovenija › Osrednjeslovenska
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Janez Kerc (Dr.)
• Total cost: No data

CROMA-PHARMA GMBH

Participation ended

Austria

• EU contribution: € 80 668,27
• Address: INDUSTRIZEILE 6 ; 2100 LEOBENDORF
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Christian Huber (Mr.)
• Total cost: No data

NANOMI BV

Participation ended

Netherlands

• EU contribution: € 119 835,00
• Address: ZUTPHENSTRAAT 51 ; 7575 EJ OLDENZAAL
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Gert Veldhuis (Dr.)
• Total cost: No data

THIOMATRIX FORSCHUNGS UND BERATUNGS GMBH

Austria

• EU contribution: € 718 986,00
• Address: UNTERER PLATZ 22 ; 9300 ST VEIT AN DER GLAN
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Andreas Bernkop-Schnürch (Prof.)
• Total cost: No data

SAGETIS BIOTECH SL

Spain

• EU contribution: € 769 063,20
• Address: VIA AUGUSTA 390 ; 08017 BARCELONA
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Eduard Diviu Terradas (Mr.)
• Total cost: No data

MERCK SERONO SPA

Participation ended

Italy

• EU contribution: No data
• Address: VIA CASILINA 125 ; 00176 ROMA
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Daniel Leblanc (Mr.)
• Total cost: No data

UNIVERSITY OF GREENWICH

United Kingdom

• EU contribution: € 472 130,96
• Address: PARK ROW GREENWICH OLD ROYAL NAVAL COLLEGE ; SE10 9LS London
• Region: London › Outer London — East and North East › Bexley and Greenwich
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Alison Yakub (Ms.)
• Total cost: No data

BOEHRINGER INGELHEIM INTERNATIONALGMBH

Participation ended

Germany

• EU contribution: No data
• Address: BINGER STRASSE ; 55218 Ingelheim
• Region: Rheinland-Pfalz › Rheinhessen-Pfalz › Mainz-Bingen
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Pascal Badalucco
• Total cost: No data

ITA-SUOMEN YLIOPISTO

Finland

• EU contribution: € 388 332,34
• Address: YLIOPISTONRANTA 8 ; 70211 KUOPIO
• Region: Manner-Suomi › Pohjois- ja Itä-Suomi › Pohjois-Savo
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Timo Hartikainen (Dr.)
• Total cost: No data

EVONIK NUTRITION & CARE GMBH

Germany

• EU contribution: € 207 639,00
• Address: RELLINGHAUSER STRASSE 1 11 ; 45128 ESSEN
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Mark Knochenhauer
• Total cost: No data

BOEHRINGER INGELHEIM PHARMA GMBH &CO KG

Germany

• EU contribution: € 116 100,00
• Address: BINGER STRASSE 173 ; 55218 Ingelheim
• Region: Rheinland-Pfalz › Rheinhessen-Pfalz › Mainz-Bingen
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Alexander Jung (Dr.)
• Total cost: No data