Objective The objective of the ALEXANDER project is the identification of novel strategies (e.g. proteolytic enzyme strategy, thiomer strategy, zeta potential changing systems, SNEDDS strategy) and the optimization of existing strategies (e.g. disulfide breaking strategy and slippery surface strategy) for the efficient transport of nanocarriers through the mucus gel layer (e.g. intestinal, nasal, ocular, vaginal, buccal, pulmonary). In particular, R&D activities will be focused on the synthesis of functionalized nanocarriers capable of permeating the mucus gel layer and delivering their therapeutic payload to the epithelium. The nanocarriers will be characterized with respect to their physicochemical properties, ability to cross the mucus gel layer, in vitro and in vivo cytotoxicity. The potential of the developed nanocarriers as delivery systems for mucosal administration of macromolecules will be demonstrated via the oral delivery of peptides, oligosaccharides and oligonucleotides and the nasal delivery of a plasmid encoding for an antigen. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP.2011.1.2-2 - New targeted therapy using nanotechnology for transport of macro-molecules across biological barriers Call for proposal FP7-NMP-2011-LARGE-5 See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator DECHEMA GESELLSCHAFT FUR CHEMISCHETECHNIK UND BIOTECHNOLOGIE Address Theodor heuss allee 25 60486 Frankfurt Germany See on map Region Hessen Darmstadt Frankfurt am Main, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Andreas Förster (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 1 015 908,63 Participants (18) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITAET INNSBRUCK Austria EU contribution € 692 998,80 Address Innrain 52 6020 Innsbruck See on map Region Westösterreich Tirol Innsbruck Activity type Higher or Secondary Education Establishments Administrative Contact Andreas Bernkop-Schnuerch (Prof.) Links Contact the organisation Opens in new window Website Opens in new window ARISTOTELIO PANEPISTIMIO THESSALONIKIS Greece EU contribution € 580 744,40 Address Kedea building, tritis septemvriou, aristotle university campus 546 36 Thessaloniki See on map Region Βόρεια Ελλάδα Κεντρική Μακεδονία Θεσσαλονίκη Activity type Higher or Secondary Education Establishments Administrative Contact Georgia Petridou (Ms.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITY OF NEWCASTLE UPON TYNE United Kingdom EU contribution € 633 211,20 Address Kings gate NE1 7RU Newcastle upon tyne See on map Region North East (England) Northumberland and Tyne and Wear Tyneside Activity type Higher or Secondary Education Establishments Administrative Contact Aleona Blinova (Ms.) Links Contact the organisation Opens in new window Website Opens in new window CARDIFF UNIVERSITY United Kingdom EU contribution € 288 002,90 Address Newport road 30 36 CF24 0DE Cardiff See on map Region Wales East Wales Cardiff and Vale of Glamorgan Activity type Higher or Secondary Education Establishments Administrative Contact Nick Bodycombe (Mr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSIDAD DE NAVARRA Spain EU contribution € 728 634,80 Address Campus universitario edificio central 31080 Pamplona See on map Region Noreste Comunidad Foral de Navarra Navarra Activity type Higher or Secondary Education Establishments Administrative Contact Iñigo Uriarte Pueyo (Dr.) Links Contact the organisation Opens in new window Website Opens in new window INSTITUT JOZEF STEFAN Slovenia EU contribution € 565 000,00 Address Jamova 39 1000 Ljubljana See on map Region Slovenija Zahodna Slovenija Osrednjeslovenska Activity type Research Organisations Administrative Contact Jadran Lenarcic (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EVONIK INDUSTRIES AG Participation ended Germany EU contribution € 376 949,50 Address Rellinghauser strasse 1-11 45128 Essen See on map Region Nordrhein-Westfalen Düsseldorf Essen, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Rosario Lizio (Dr.) Links Contact the organisation Opens in new window Website Opens in new window LEK FARMACEVTSKA DRUZBA DD Slovenia EU contribution € 343 997,00 Address Verovskova ulica 57 1526 Ljubljana See on map Region Slovenija Zahodna Slovenija Osrednjeslovenska Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Janez Kerc (Dr.) Links Contact the organisation Opens in new window Website Opens in new window CROMA-PHARMA GMBH Participation ended Austria EU contribution € 80 668,27 Address Industrizeile 6 2100 Leobendorf See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Christian Huber (Mr.) Links Contact the organisation Opens in new window Website Opens in new window NANOMI BV Participation ended Netherlands EU contribution € 119 835,00 Address Zutphenstraat 51 7575 EJ Oldenzaal See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Gert Veldhuis (Dr.) Links Contact the organisation Opens in new window Website Opens in new window THIOMATRIX FORSCHUNGS UND BERATUNGS GMBH Austria EU contribution € 718 986,00 Address Unterer platz 22 9300 St veit an der glan See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Andreas Bernkop-Schnürch (Prof.) Links Contact the organisation Opens in new window Website Opens in new window SAGETIS BIOTECH SL Spain EU contribution € 769 063,20 Address Via augusta 390 08017 Barcelona See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Eduard Diviu Terradas (Mr.) Links Contact the organisation Opens in new window MERCK SERONO SPA Participation ended Italy EU contribution € 0,00 Address Via casilina 125 00176 Roma See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Daniel Leblanc (Mr.) Links Contact the organisation Opens in new window UNIVERSITY OF GREENWICH United Kingdom EU contribution € 472 130,96 Address Park row greenwich old royal naval college SE10 9LS London See on map Region London Outer London — East and North East Bexley and Greenwich Activity type Higher or Secondary Education Establishments Administrative Contact Alison Yakub (Ms.) Links Contact the organisation Opens in new window Website Opens in new window BOEHRINGER INGELHEIM INTERNATIONALGMBH Participation ended Germany EU contribution € 0,00 Address Binger strasse 55218 Ingelheim See on map Region Rheinland-Pfalz Rheinhessen-Pfalz Mainz-Bingen Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Pascal Badalucco Links Contact the organisation Opens in new window Website Opens in new window ITA-SUOMEN YLIOPISTO Finland EU contribution € 388 332,34 Address Yliopistonranta 1 e 70211 Kuopio See on map Region Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Savo Activity type Higher or Secondary Education Establishments Administrative Contact Timo Hartikainen (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EVONIK NUTRITION & CARE GMBH Germany EU contribution € 207 639,00 Address Rellinghauser strasse 1 11 45128 Essen See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Mark Knochenhauer Links Contact the organisation Opens in new window Website Opens in new window BOEHRINGER INGELHEIM PHARMA GMBH &CO KG Germany EU contribution € 116 100,00 Address Binger strasse 173 55218 Ingelheim See on map Region Baden-Württemberg Stuttgart Stuttgart, Stadtkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Alexander Jung (Dr.) Links Contact the organisation Opens in new window Website Opens in new window
