Objective
The objective of the ALEXANDER project is the identification of novel strategies (e.g. proteolytic enzyme strategy, thiomer strategy, zeta potential changing systems, SNEDDS strategy) and the optimization of existing strategies (e.g. disulfide breaking strategy and slippery surface strategy) for the efficient transport of nanocarriers through the mucus gel layer (e.g. intestinal, nasal, ocular, vaginal, buccal, pulmonary). In particular, R&D activities will be focused on the synthesis of functionalized nanocarriers capable of permeating the mucus gel layer and delivering their therapeutic payload to the epithelium. The nanocarriers will be characterized with respect to their physicochemical properties, ability to cross the mucus gel layer, in vitro and in vivo cytotoxicity. The potential of the developed nanocarriers as delivery systems for mucosal administration of macromolecules will be demonstrated via the oral delivery of peptides, oligosaccharides and oligonucleotides and the nasal delivery of a plasmid encoding for an antigen.
Programme(s)
Call for proposal
FP7-NMP-2011-LARGE-5
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Funding Scheme
CP-IP - Large-scale integrating projectCoordinator
60486 Frankfurt
Germany
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Participants (18)
6020 Innsbruck
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546 36 THESSALONIKI
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NE1 7RU Newcastle Upon Tyne
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CF24 0DE Cardiff
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31080 Pamplona
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1000 Ljubljana
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45128 Essen
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1526 LJUBLJANA
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2100 LEOBENDORF
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7575 EJ OLDENZAAL
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9300 ST VEIT AN DER GLAN
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08017 BARCELONA
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00176 ROMA
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SE10 9LS London
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55218 Ingelheim
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70211 KUOPIO
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45128 ESSEN
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55218 Ingelheim
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