Objective Neurogenesis in the mammalian neocortex depends upon asymmetric cell divisions to maintain a balance between self-renewal and neuronal differentiation. This process is likely a key element governing the expansion of the human cerebral cortex, and its disruption can lead to severe developmental disorders such as microcephaly and lissencephaly. However, mechanisms of asymmetric cell division in mammalian brain development are largely unclear, and its potential role in human cortical development has not been examined. Substantial headway has been made in understanding mechanisms of asymmetric cell division in the Drosophila central nervous system. Our lab has recently published a genome-wide RNAi screen, which has identified several novel regulators of asymmetric cell division in Drosophila. To test whether these newly identified factors have conserved roles in mammals, I will use mouse neural rosettes to screen and perform functional assessments of the promising candidates. I will then perform functional studies of human neural rosettes to test our candidates, as well as previously identified regulators of asymmetric cell division. In this way, I will utilize the neural rosettes system to screen for new regulators of self-renewal and differentiation and examine the role of asymmetric cell division in human cortical development. Fields of science natural sciencesbiological sciencesneurobiologynatural sciencesbiological scienceszoologymammalogy Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2011-IIF - Marie Curie Action: "International Incoming Fellowships" Call for proposal FP7-PEOPLE-2011-IIF See other projects for this call Funding Scheme MC-IIF - International Incoming Fellowships (IIF) Coordinator INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH EU contribution € 187 888,20 Address DR BOHRGASSE 3 1030 Wien Austria See on map Region Ostösterreich Wien Wien Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Tanja Winkler (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
