Objective
Adult stem cells (SCs), also known as tissue SCs, support tissue homeostasis and repair throughout the entire life of the organism. The remarkable longevity of tissue SCs relies on their unique ability to asymmetrically generate new SCs (self-renewal) as well as specialized cell types (differentiation). Notably, many genes that signal to regulate the balance between renewal and differentiation encode proteins as well as small RNA molecules, predicted to regulate specific mRNAs. This proposal is aimed to uncover RNA regulation networks essential for maintaining an adult germline stem cells (GSCs) pool, and for preventing differentiation along the germline lineage. Ultimately, I wish to understand in molecular details how the activities of diverse post-transcriptional factors are coordinated in space and time to give a functional tissue homeostasis. Using the Drosophila testis - a stem cell based tissue model in which stem cells and the niche have been defined and can be manipulated, I aim to investigate SCs regulation by conserved RNA regulators. To pursue these interests I will use a variety of biochemical and genetic assays in the highly genetically amenable model organism, Drosophila melanogaster.
Given that tissue homeostasis and repair supported by adult SCs is a primordial mechanism of multicellular animals, I anticipate the functional importance of many of the genes to be identified will be conserved between flies and mammals. Understanding the mechanistic basis of adult SC self-renewal, as well as of regulating the differentiation and proliferation of their progeny, will ultimately facilitate stem cell based therapies for regenerative medicine including age-onset diseases and cancer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences zoology mammalogy
- medical and health sciences basic medicine physiology homeostasis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IIF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
32000 Haifa
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.